Synergy between time-restricted feeding and time-restricted running is necessary to shift the muscle clock in male wistar rats

Circadian disruption is an important factor driving the current-day high prevalence of obesity and type-2 diabetes. While the impact of incorrect timing of caloric intake on circadian disruption is widely acknowlegded, the contribution of incorrect timing of physical activity remains relatively unde...

Full description

Saved in:

Bibliographic Details
Published in:	Neurobiology of sleep and circadian rhythms Vol. 17; p. 100106
Main Authors:	Shiba, Ayano, de Goede, Paul, Tandari, Roberta, Foppen, Ewout, Korpel, Nikita L., Coopmans, Tom V., Hellings, Tom P., Jansen, Merel W., Ruitenberg, Annelou, Ritsema, Wayne I.G.R., Yi, Chun-Xia, Mul, Joram D., Stenvers, Dirk Jan, Kalsbeek, Andries
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2024 Elsevier
Subjects:	Circadian misalignment Energy metabolism Liver Muscle Research Paper Time restriction Wheel running Wheel running Energy metabolism Muscle Time restriction Circadian misalignment Liver
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Circadian disruption is an important factor driving the current-day high prevalence of obesity and type-2 diabetes. While the impact of incorrect timing of caloric intake on circadian disruption is widely acknowlegded, the contribution of incorrect timing of physical activity remains relatively understudied. Here, we modeled the incorrect timing of physical activity in nightshift workers in male Wistar rats, by restricting running wheel access to the innate inactive (light) phase (LR). Controls included no wheel access (NR); access only during the innate active (dark) period (DR); or unrestricted (ad libitum) access (ALR). LR did not shift the phase of the muscle or liver clock, but dampened the muscle clock amplitude. As our previous study demonstrated that light-phase restricted feeding did shift the liver clock, but made the muscle clock arrhythmic, we next combined the time restriction of wheel and food access to either the light phase (LRLF) or dark phase (DRDF). LRLF produced a ∼12 h shift in the majority of clock gene rhythms in both skeletal muscle and liver. On the other hand, DRDF was most effective in reducing body weight and the accumulation of fat mass. Therefore, in order to shift the muscle clock in male Wistar rats, synergy between the timing of feeding and physical activity is necessary. These findings may contribute to further improve the design of lifestyle strategies that try to limit metabolic misalignment caused by circadian disruption. [Display omitted] •Voluntary wheel running (VWR) in the active phase boosts the muscle clock amplitude.•VWR in the active phase blunts weight gain most effectively.•VWR in the inactive phase dampens the skeletal muscle clock gene expression rhythm.•Inactive-phase restricted VWR and feeding shifts the liver and muscle clock by ∼12 h.•Active-phase restricted VWR and feeding prevents weight gain and adiposity the best.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally.
ISSN:	2451-9944 2451-9944
DOI:	10.1016/j.nbscr.2024.100106