Search Results - "Ruimi, Nili"

Natural products as potential cancer therapy enhancers: A preclinical update by Agbarya, Abed, Ruimi, Nili, Epelbaum, Ron, Ben-Arye, Eran, Mahajna, Jamal

“…Cancer is a multifactorial disease that arises as a consequence of alterations in many physiological processes. Recently, hallmarks of cancer were suggested…”
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Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism by Khateb, Mamduh, Ruimi, Nili, Khamisie, Hazem, Najajreh, Yousef, Mian, Afsar, Metodieva, Anna, Ruthardt, Martin, Mahajna, Jamal

“…Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase…”
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Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I by Mian, Afsar Ali, Metodieva, Anna, Badura, Susanne, Khateb, Mamduh, Ruimi, Nili, Najajreh, Yousef, Ottmann, Oliver Gerhard, Mahajna, Jamal, Ruthardt, Martin

“…Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to…”
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A Small Molecule Inhibitor of Bruton’s Tyrosine Kinase Involved in B‑Cell Signaling by Ratzon, Einav, Bloch, Itai, Nicola, Meshel, Cohen, Elad, Ruimi, Nili, Dotan, Nesly, Landau, Meytal, Gal, Maayan

“…Protein kinases are fundamental within almost all cellular signal transduction networks. Among these, Bruton’s tyrosine kinase (Btk), which belongs to the Tec…”
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Development of toxin-antitoxin self-destructive bacteria, aimed for salmonella vaccination by Gruzdev, Nady, Pitcovski, Jacob, Katz, Chen, Ruimi, Nili, Eliahu, Dalia, Noach, Caroline, Rosenzweig, Ella, Finger, Avner, Shahar, Ehud

“…The most common source of foodborne Salmonella infection in humans is poultry eggs and meat, such that prevention of human infection is mostly achieved by…”
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Inhibition of PD1:PD-L1 interaction by an E. coli-derived optimized PD1 variant by Brand Shwartz, Michal, Assor, Mayan, Dotan, Nesly, Ratzon, Einav, Cohen, Elad, Ruimi, Nili, Bloch, Itai, Gal, Maayan, Yadid, Itamar

“…Immune-checkpoint receptors are a set of signal transduction proteins that can stimulate or inhibit specific anti-tumor responses. It is well established that…”
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Ectopic Expression of Snail and Twist in Ph+ Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential by Kidan, Noa, Khamaisie, Hazem, Ruimi, Nili, Roitman, Shay, Eshel, Elizabeth, Dally, Najib, Ruthardt, Martin, Mahajna, Jamal

“…Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein…”
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Oleylamine-carbonyl-valinol inhibits auto-phosphorylation activity of native and T315I mutated Bcr-Abl, and exhibits selectivity towards oncogenic Bcr-Abl in SupB15 ALL cell lines by Najajreh, Yousef, Khamaisie, Hazem, Ruimi, Nili, Khatib, Soliman, Katzhendler, Joshua, Ruthardt, Martin, Mahajna, Jamal

“…Chronic myeloid leukemia (CML) is characterized by the presence of p210 Bcr-Abl which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors…”
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Inhibition of TNFα-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-κB- and MAPK-dependent mechanisms by Ruimi, Nili, Petrova, Roumyana D., Agbaria, Riad, Sussan, Sherbel, Wasser, Solomon P., Reznick, Abraham Z., Mahajna, Jamal

“…Nitric oxide (NO) is a gaseous, radical molecule that plays a role in various physiological processes. Previously, we reported that transduction of murine…”
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Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-κB and MAPK activities in RAW 264.7 macrophage cells by Ruimi, Nili, Rwashdeh, Haithem, Wasser, Solomon, Konkimalla, Badireenath, Efferth, Thomas, Borgatti, Monica, Gambari, Roberto, Mahajna, Jamal

“…Nitric oxide (NO) is a radical molecule produced by iNOS and plays a role in various physiological and pathophysiological conditions including inflammatory…”
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Marasmius oreades substances block NF-κB activity through interference with IKK activation pathway by Petrova, Roumyana D, Mahajna, Jamal, Wasser, Solomon P, Ruimi, Nili, Denchev, Cvetomir M, Sussan, Sherbel, Nevo, Eviatar, Reznick, Abraham Z

“…The activation pathway of nuclear transcription factor kappa B (NF-κB) is a key mechanism for the progression of carcinogenesis at the molecular level. NF-κB…”
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Inhibition of TNF[alpha]-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-[kappa]B- and MAPK-dependent mechanisms by Ruimi, Nili, Petrova, Roumyana D, Agbaria, Riad, Sussan, Sherbel, Wasser, Solomon P, Reznick, Abraham Z, Mahajna, Jamal

“…Nitric oxide (NO) is a gaseous, radical molecule that plays a role in various physiological processes. Previously, we reported that transduction of murine…”
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The Shaggy Inc Cap medicinal mushroom, Coprinus comatus (O.F.Mull.: Fr.) Pers. (Agaricomycetideae) substances interfere with H2O2 induction of the NF-kappaB pathway through inhibition of Ikappaalpha phosphorylation in MCF7 breast cancer cells by Asatiani, Mikheil D, Wasser, Solomon P, Nevo, Eviatar, Ruimi, Nili, Mahajna, Jamal, Reznick, Abraham Z

“…Breast cancer is the most commonly diagnosed cancer among women. Currently, there is no effective therapy for malignant estrogen-independent breast cancer. In…”
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Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway by Petrova, Roumyana D, Mahajna, Jamal, Wasser, Solomon P, Ruimi, Nili, Denchev, Cvetomir M, Sussan, Sherbel, Nevo, Eviatar, Reznick, Abraham Z

“…The activation pathway of nuclear transcription factor kappa B (NF-kappaB) is a key mechanism for the progression of carcinogenesis at the molecular level…”
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Marasmius oreades substances block NF-[kappa]B activity through interference with IKK activation pathway by Petrova, Roumyana D, Mahajna, Jamal, Wasser, Solomon P, Ruimi, Nili, Denchev, Cvetomir M, Sussan, Sherbel, Nevo, Eviatar, Reznick, Abraham Z

“…The activation pathway of nuclear transcription factor kappa B (NF-κB) is a key mechanism for the progression of carcinogenesis at the molecular level. NF-κB…”
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חומרים מפטריית הבסיסה Daedalea Gibbosa מעכבים ביטוי ופעילות של האנזים iNos by רואימי, נילי, Ruimi, Nili

“…(NO (oxide nitric הוא רדיקל גזי, מולקולה ייחודית במסלולי העברת סיגנל בתא, המתפקדת כשליח תוך-תאי ובין-תאי המעורב במגוון תהליכים פיסיולוגים במערכת…”
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Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-kappaB and MAPK activities in RAW 264.7 macrophage cells by Ruimi, Nili, Rwashdeh, Haithem, Wasser, Solomon, Konkimalla, Badireenath, Efferth, Thomas, Borgatti, Monica, Gambari, Roberto, Mahajna, Jamal

“…Nitric oxide (NO) is a radical molecule produced by iNOS and plays a role in various physiological and pathophysiological conditions including inflammatory…”
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