Search Results - "Ruibal, Paula"

Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever by Oestereich, Lisa, Lüdtke, Anja, Ruibal, Paula, Pallasch, Elisa, Kerber, Romy, Rieger, Toni, Wurr, Stephanie, Bockholt, Sabrina, Pérez-Girón, José V, Krasemann, Susanne, Günther, Stephan, Muñoz-Fontela, César

“…Lassa fever (LASF) is a highly severe viral syndrome endemic to West African countries. Despite the annual high morbidity and mortality caused by LASF, very…”
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Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes by Wawina-Bokalanga, Tony, Vanmechelen, Bert, Lhermitte, Valentine, Martí-Carreras, Joan, Vergote, Valentijn, Koundouno, Fara Raymond, Akoi-Boré, Joseph, Thom, Ruth, Tipton, Tom, Steeds, Kimberley, Moussa, Kéita Balla, Amento, Ablam, Laenen, Lies, Duraffour, Sophie, Gabriel, Martin, Ruibal, Paula, Hall, Yper, Kader-Kondé, Mandy, Günther, Stephan, Baele, Guy, Muñoz-Fontela, Cesar, Van Weyenbergh, Johan, Carroll, Miles W, Maes, Piet

“…We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We studied the relationship between…”
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Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16⁺ Monocytes by Lüdtke, Anja, Ruibal, Paula, Becker-Ziaja, Beate, Rottstegge, Monika, Wozniak, David M., Cabeza-Cabrerizo, Mar, Thorenz, Anja, Weller, Romy, Kerber, Romy, Idoyaga, Juliana, Magassouba, N'Faly, Gabriel, Martin, Günther, Stephan, Oestereich, Lisa, Muñoz-Fontela, César

“…A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus…”
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Ebola Virus Disease Survivors Show More Efficient Antibody Immunity than Vaccinees Despite Similar Levels of Circulating Immunoglobulins by Koch, Till, Rottstegge, Monika, Ruibal, Paula, Gomez-Medina, Sergio, Nelson, Emily V, Escudero-Pérez, Beatriz, Pillny, Matthias, Ly, My Linh, Koundouno, Fara Raymond, Bore, Joseph Akoi, Magassouba, N'Faly, Dahlke, Christine, Günther, Stephan, Carroll, Miles W, Addo, Marylyn M, Muñoz-Fontela, César

“…The last seven years have seen the greatest surge of Ebola virus disease (EVD) cases in equatorial Africa, including the 2013-2016 epidemic in West Africa and…”
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Regulation of Ebola virus VP40 matrix protein by SUMO by Baz-Martínez, Maite, El Motiam, Ahmed, Ruibal, Paula, Condezo, Gabriela N., de la Cruz-Herrera, Carlos F., Lang, Valerie, Collado, Manuel, San Martín, Carmen, Rodríguez, Manuel S., Muñoz-Fontela, Cesar, Rivas, Carmen

“…The matrix protein of Ebola virus (EBOV) VP40 regulates viral budding, nucleocapsid recruitment, virus structure and stability, viral genome replication and…”
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Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire by Voogd, Linda, Drittij, Anne M.H.F., Dingenouts, Calinda K.E., Franken, Kees L.M.C., Unen, Vincent van, van Meijgaarden, Krista E., Ruibal, Paula, Hagedoorn, Renate S., Leitner, Judith A., Steinberger, Peter, Heemskerk, Mirjam H.M., Davis, Mark M., Scriba, Thomas J., Ottenhoff, Tom H.M., Joosten, Simone A.

“…HLA-E molecules can present self- and pathogen-derived peptides to both natural killer (NK) cells and T cells. T cells that recognize HLA-E peptides via their…”
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The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity by Ruibal, Paula, Voogd, Linda, Joosten, Simone A., Ottenhoff, Tom H. M.

“…Vaccination strategies against mycobacteria, focusing mostly on classical T‐ and B‐cells, have shown limited success, encouraging the addition of alternative…”
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Antigen presentation by MHC-E: a putative target for vaccination? by Voogd, Linda, Ruibal, Paula, Ottenhoff, Tom H.M., Joosten, Simone A.

“…The essentially monomorphic human antigen presentation molecule HLA-E is an interesting candidate target to enable vaccination irrespective of genetic…”
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Domains of the Hepatitis B Virus Small Surface Protein S Mediating Oligomerization by Suffner, Sascha, Gerstenberg, Nadine, Patra, Maria, Ruibal, Paula, Orabi, Ahmed, Schindler, Michael, Bruss, Volker

“…During hepatitis B virus (HBV) infections, subviral particles (SVP) consisting only of viral envelope proteins and lipids are secreted. Heterologous expression…”
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Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever by Oestereich, Lisa, Rieger, Toni, Lüdtke, Anja, Ruibal, Paula, Wurr, Stephanie, Pallasch, Elisa, Bockholt, Sabrina, Krasemann, Susanne, Muñoz-Fontela, César, Günther, Stephan

“…We studied the therapeutic potential of favipiravir (T-705) for Lassa fever, both alone and in combination with ribavirin. Favipiravir suppressed Lassa virus…”
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Avatar Mice Underscore the Role of the T Cell-Dendritic Cell Crosstalk in Ebola Virus Disease and Reveal Mechanisms of Protection in Survivors by Rottstegge, Monika, Tipton, Tom, Oestereich, Lisa, Ruibal, Paula, Nelson, Emily V., Olal, Catherine, Port, Julia R., Seibel, Johan, Pallasch, Elisa, Bockholt, Sabrina, Koundouno, Fara Raymond, Boré, Joseph Akoi, Rodríguez, Estefanía, Escudero-Pérez, Beatriz, Günther, Stephan, Carroll, Miles W., Muñoz-Fontela, César

“…Ebola virus disease (EVD) is a complex infectious disease characterized by high inflammation, multiorgan failure, the dysregulation of innate and adaptive…”
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Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues by Ruibal, Paula, Franken, Kees L M C, van Meijgaarden, Krista E, van Loon, Joeri J F, van der Steen, Dirk, Heemskerk, Mirjam H M, Ottenhoff, Tom H M, Joosten, Simone A

“…Ag presentation via the nonclassical MHC class Ib molecule HLA-E, with nearly complete identity between the two alleles expressed in humans, HLA-E*01:01 and…”
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T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans by Speranza, Emily, Ruibal, Paula, Port, Julia R, Feng, Feng, Burkhardt, Lia, Grundhoff, Adam, Günther, Stephan, Oestereich, Lisa, Hiscox, Julian A, Connor, John H, Muñoz-Fontela, César

“…Differences in T-cell phenotype, particularly the expression of markers of T-cell homeostasis, have been observed in fatal and nonfatal Ebola virus disease…”
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Identification of novel HLA-E-binding Mtb-derived epitopes through improved prediction models by Ruibal, Paula, Franken, Kees L. M. C., van Meijgaarden, Krista E., van Wolfswinkel, Marjolein, Derksen, Ian, Scheeren, Ferenc A., Janssen, George M. C., van Veelen, Peter A., Sarfas, Charlotte, White, Andrew D., Sharpe, Sally A., Palmieri, Fabrizio, Petrone, Linda, Goletti, Delia, Abeel, Thomas, Ottenhoff, Tom H. M., Joosten, Simone A.

“…Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, posing great social and economic burden to affected countries. Novel vaccine…”
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Identification of HLA-E Binding Mycobacterium tuberculosis -Derived Epitopes through Improved Prediction Models by Ruibal, Paula, Franken, Kees L M C, van Meijgaarden, Krista E, van Wolfswinkel, Marjolein, Derksen, Ian, Scheeren, Ferenc A, Janssen, George M C, van Veelen, Peter A, Sarfas, Charlotte, White, Andrew D, Sharpe, Sally A, Palmieri, Fabrizio, Petrone, Linda, Goletti, Delia, Abeel, Thomas, Ottenhoff, Tom H M, Joosten, Simone A

“…Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, posing great social and economic burden to affected countries. Novel vaccine…”
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Ebola virus disease in mice with transplanted human hematopoietic stem cells by Lüdtke, Anja, Oestereich, Lisa, Ruibal, Paula, Wurr, Stephanie, Pallasch, Elisa, Bockholt, Sabrina, Ip, Wing Hang, Rieger, Toni, Gómez-Medina, Sergio, Stocking, Carol, Rodríguez, Estefanía, Günther, Stephan, Muñoz-Fontela, César

“…The development of treatments for Ebola virus disease (EVD) has been hampered by the lack of small-animal models that mimick human disease. Here we show that…”
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Discovery of HLA-E-Presented Epitopes: MHC-E/Peptide Binding and T-Cell Recognition by Ruibal, Paula, Franken, Kees L M C, van Meijgaarden, Krista E, Walters, Lucy C, McMichael, Andrew J, Gillespie, Geraldine M, Joosten, Simone A, Ottenhoff, Tom H M

“…Understanding the interactions involved during the immunological synapse between peptide, HLA-E molecules, and TCR is crucial to effectively target protective…”
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Thermal‐exchange HLA‐E multimers reveal specificity in HLA‐E and NKG2A/CD94 complex interactions by Ruibal, Paula, Derksen, Ian, Wolfswinkel, Marjolein, Voogd, Linda, Franken, Kees L. M. C., El Hebieshy, Angela F., Hall, Thorbald, Schoufour, Tom A. W., Wijdeven, Ruud H., Ottenhoff, Tom H. M., Scheeren, Ferenc A., Joosten, Simone A.

“…There is growing interest in HLA‐E‐restricted T‐cell responses as a possible novel, highly conserved, vaccination targets in the context of infectious and…”
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Longitudinal soluble marker profiles reveal strong association between cytokine storms resulting from macrophage activation and disease severity in COVID-19 disease by van Meijgaarden, Krista E., van Veen, Suzanne, Tsonaka, Roula, Ruibal, Paula, Roukens, Anna H. E., Arbous, Sesmu M., Manniën, Judith, Cannegieter, Suzanne C., Ottenhoff, Tom H. M., Joosten, Simone A.

“…SARS-CoV2 infection results in a range of disease severities, but the underlying differential pathogenesis is still not completely understood. At presentation…”
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Ebola virus infection kinetics in chimeric mice reveal a key role of T cells as barriers for virus dissemination by Lüdtke, Anja, Ruibal, Paula, Wozniak, David M., Pallasch, Elisa, Wurr, Stephanie, Bockholt, Sabrina, Gómez-Medina, Sergio, Qiu, Xiangguo, Kobinger, Gary P., Rodríguez, Estefanía, Günther, Stephan, Krasemann, Susanne, Idoyaga, Juliana, Oestereich, Lisa, Muñoz-Fontela, César

“…Ebola virus (EBOV) causes severe systemic disease in humans and non-human primates characterized by high levels of viremia and virus titers in peripheral…”
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