Search Results - "Ruhoff, Mary S."

PKCδ Is Activated in a Dietary Model of Steatohepatitis and Regulates Endoplasmic Reticulum Stress and Cell Death by Greene, Michael W., Burrington, Christine M., Ruhoff, Mary S., Johnson, Andrew K., Chongkrairatanakul, Tepsiri, Kangwanpornsiri, Atipon

“…Hepatic steatosis can progress to the clinical condition of non-alcoholic steatohepatitis (NASH), which is a precursor of more serious liver diseases. The…”
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PKCδ is activated in the liver of obese Zucker rats and mediates diet-induced whole body insulin resistance and hepatocyte cellular insulin resistance by Greene, Michael W., Burrington, Christine M., Luo, Yuwen, Ruhoff, Mary S., Lynch, Darin T., Chaithongdi, Niyutchai

“…Insulin resistance can arise when pathological levels of free fatty acids (FFAs) and proinflammatory cytokines disrupt insulin signaling. Protein kinase C…”
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Location of the mutation site in the first two reported cases of analbuminemia by Ruhoff, Mary S., Greene, Michael W., Peters, Theodore

“…To find the mutation causing the first two reported cases of analbuminemia. DNA was extracted from blocks of fixed embedded liver. Exons of the albumin gene…”
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Stimulation of lipolysis by tumor necrosis factor-α in 3T3-L1 adipocytes is glucose dependent: Implications for long-term regulation of lipolysis by GREEN, Allan, RUMBERGER, John M, STUART, Charles A, RUHOFF, Mary S

“…Tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia both impair insulin sensitivity in vivo. This may be secondary to stimulation of adipose tissue…”
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Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events by BLASK, D. E, SAUER, L. A, DAUCHY, R. T, HOLOWACHUK, E. W, RUHOFF, M. S, KOPFF, H. S

“…The growth of rat hepatoma 7288CTC in vivo is stimulated by the uptake of linoleic acid (LA) and its metabolism to 13-hydroxyoctadecadienoic acid (13-HODE), an…”
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Stimulation of Lipolysis by Tumor Necrosis Factor-α in 3T3-L1 Adipocytes Is Glucose Dependent by Green, Allan, Rumberger, John M., Stuart, Charles A., Ruhoff, Mary S.

“…Stimulation of Lipolysis by Tumor Necrosis Factor-α in 3T3-L1 Adipocytes Is Glucose Dependent Implications for Long-Term Regulation of Lipolysis Allan Green 1…”
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TNFα activation of PKCδ, mediated by NFκB and ER stress, cross-talks with the insulin signaling cascade by Greene, Michael W., Ruhoff, Mary S., Burrington, Christine M., Garofalo, Robert S., Oreña, Stephen J.

“…TNFα plays key roles in the regulation of inflammation, cell death, and proliferation and its signaling cascade cross-talks with the insulin signaling cascade…”
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PKCδ-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function by Greene, Michael W., Ruhoff, Mary S., Roth, Richard A., Kim, Jeong-a, Quon, Michael J., Krause, Jean A.

“…The IRS-1 PH and PTB domains are essential for insulin-stimulated IRS-1 Tyr phosphorylation and insulin signaling, while Ser/Thr phosphorylation of IRS-1…”
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Modulation of IRS-1 PH and PTB Domain Function by Phosphorylation by Greene, Michael W, Ruhoff, Mary S

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PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function by Greene, Michael W, Ruhoff, Mary S, Roth, Richard A, Kim, Jeong-A, Quon, Michael J, Krause, Jean A

“…The IRS-1 PH and PTB domains are essential for insulin-stimulated IRS-1 Tyr phosphorylation and insulin signaling, while Ser/Thr phosphorylation of IRS-1…”
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PKC{delta}-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function by Greene, Michael W., Ruhoff, Mary S., Roth, Richard A., Kim, Jeong-a, Quon, Michael J., Krause, Jean A.

“…The IRS-1 PH and PTB domains are essential for insulin-stimulated IRS-1 Tyr phosphorylation and insulin signaling, while Ser/Thr phosphorylation of IRS-1…”
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PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death by Greene, Michael W, Burrington, Christine M, Ruhoff, Mary S, Johnson, Andrew K, Chongkrairatanakul, Tepsiri, Kangwanpornsiri, Atipon

“…Hepatic steatosis can progress to the clinical condition of non-alcoholic steatohepatitis (NASH), which is a precursor of more serious liver diseases. The…”
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Stimulation of Lipolysis by Tumor Necrosis Factor-[alpha] in 3T3-L1 Adipocytes Is Glucose Dependent: Implications for Long-Term Regulation of Lipolysis by Green, Allan, Rumberger, John M, Stuart, Charles A, Ruhoff, Mary S

“…Tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia both impair insulin sensitivity in vivo. This may be secondary to stimulation of adipose tissue…”
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TNFalpha activation of PKCdelta, mediated by NFkappaB and ER stress, cross-talks with the insulin signaling cascade by Greene, Michael W, Ruhoff, Mary S, Burrington, Christine M, Garofalo, Robert S, Oreña, Stephen J

“…TNFalpha plays key roles in the regulation of inflammation, cell death, and proliferation and its signaling cascade cross-talks with the insulin signaling…”
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Restoration of Abated T Cell Stimulation Activity of Mature Dendritic Cells by Holowachuk, Eugene W., Ruhoff, Mary S.

“…Freshly isolated and cultured mature dendritic cells (DC) rapidly lose their high capacity to activate T cells. This diminished T cell activation activity is…”
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New actions of melatonin on tumor metabolism and growth by Blask, D E, Sauer, L A, Dauchy, R, Holowachuk, E W, Ruhoff, M S

“…Melatonin is an important inhibitor of cancer growth promotion while the essential polyunsaturated fatty acid, linoleic acid is an important promoter of cancer…”
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Biologically Active Recombinant Rat Granulocyte Macrophage Colony-Stimulating Factor Produced in Escherichia coli by Holowachuk, E.W., Ruhoff, M.S.

“…Rat granuloycte macrophage colony-stimulating factor (rGM-CSF) cDNA was amplified and cloned, and recombinant-rGM-CSF (R-rGM-CSF) was expressed and isolated…”
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Conditioned medium from activated rat macrophages and the recombinant factors, IL-1 beta and GM-CSF, enhance the accessory activity of dendritic cells by Bowers, W E, Ruhoff, M S, Goodell, E M

“…Low density lymph node cells (LD-LNC; 5% of total unfractionated LNC) contain 95% of the accessory activity required for responses of T lymphocytes to…”
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The effect of silica treatment on accessory cell-dependent rat T lymphocyte proliferation by Bowers, W E, Ruhoff, M S, Goodell, E M, Stoltenborg, J K

“…Previous work has shown that purified rat macrophages lack both accessory activity for T lymphocyte responses to mitogens and stimulatory activity in a mixed…”
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