Search Results - "Ruggeri, Jeanine"

Discoidin Domain Receptor 1 (DDR1) Is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma by Ruggeri, Jeanine M., Franco-Barraza, Janusz, Sohail, Anjum, Zhang, Yaqing, Long, Daniel, Pasca di Magliano, Marina, Cukierman, Edna, Fridman, Rafael, Crawford, Howard C.

“…Pancreatic ductal adenocarcinoma (PDA) and chronic pancreatitis are characterized by a dense collagen-rich desmoplastic reaction. Discoidin domain receptor 1…”
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PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance by Roy, Nilotpal, Takeuchi, Kenneth K, Ruggeri, Jeanine M, Bailey, Peter, Chang, David, Li, Joey, Leonhardt, Laura, Puri, Sapna, Hoffman, Megan T, Gao, Shan, Halbrook, Christopher J, Song, Yan, Ljungman, Mats, Malik, Shivani, Wright, Christopher V E, Dawson, David W, Biankin, Andrew V, Hebrok, Matthias, Crawford, Howard C

“…Aberrant activation of embryonic signaling pathways is frequent in pancreatic ductal adenocarcinoma (PDA), making developmental regulators therapeutically…”
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Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis by Halbrook, Christopher J, Wen, Hui-Ju, Ruggeri, Jeanine M, Takeuchi, Kenneth K, Zhang, Yaqing, Pasca di Magliano, Marina, Crawford, Howard C

“…Background & Aims Mitogen-activated protein kinase (MAPK) signaling in the exocrine pancreas has been extensively studied in the context of pancreatic cancer,…”
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P123: Donor-cell derived hematological neoplasm: Case presentations of a complex and rare event by Ruggeri, Jeanine, Carstens, Billie, McDaniel, Veronica, Henderson, Christine, Nijmeh, Hala, Trevisan, Patricia, Balakhani, Sudabeh, Harding, Kimberly, Murakami-Walter, Aline, Ohene-Mobley, Alexandra, Swisshelm, Karen, Wicks, Stephen, Schultz-Rogers, Laura, Haag, Mary

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BRCA1 R71K missense mutation contributes to cancer predisposition by increasing alternative transcript levels by Zhang, Liying, Chen, Lishi, Bacares, Ruben, Ruggeri, Jeanine M., Somar, Joshua, Kemel, Yelena, Stadler, Zsofia K., Offit, Kenneth

“…Mutation screening of the breast and ovarian cancer predisposition genes BRCA1 and BRCA2 is becoming an increasingly important part of clinical practice…”
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Abstract 4499: Determining the role of discoidin domain receptors 1 and 2 in the pathogenesis of pancreatic ductal adenocarcinoma by Ruggeri, Jeanine, Halbrook, Christopher, Sohail, Anjum, Fridman, Rafael, Crawford, Howard

“…Pancreatic ductal adenocarcinoma (PDA) is an aggressive and devastating cancer often characterized by an intense collagen-rich, fibrotic response. In the…”
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Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency by Shia, Jinru, Zhang, Liying, Shike, Moshe, Guo, Min, Stadler, Zsofia, Xiong, Xiaoling, Tang, Laura H, Vakiani, Efsevia, Katabi, Nora, Wang, Hangjun, Bacares, Ruben, Ruggeri, Jeanine, Boland, C Richard, Ladanyi, Marc, Klimstra, David S

“…Immunohistochemical staining for DNA mismatch repair proteins may be affected by various biological and technical factors. Staining variations that could…”
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103. Formation of a ClinGen Variant Curation Expert Panel (VCEP) dedicated to Oncohistone H3 Variants in Pediatric Gliomas by Meredith, David, Saliba, Jason, Akkari, Yassmine, Lin, Wan-Hsin, Ji, Jianling, Spiteri, Elizabeth, Grisdale, Cam, Danos, Arpad, Dua, Rushil, McMullin, Erin, Ruggeri, Jeanine, Dudic, Eldar, Parsons, Donald, Brat, Daniel, Waszak, Sebastian, Mueller, Sabine, Griffith, Obi L., Griffith, Malachi, Satgunaseelan, Laveniya

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15. ClinGen Somatic Cancer expert curation panel for FGFR genes in Genitourinary Cancer by King, Ian, Saliba, Jason, Danos, Arpad, Gonzalez, Ariana, Baumann, Bethany, Walko, Christine, McMullin, Erin, Toruner, Gokce, Ruggeri, Jeanine, Hosseini, Sayed Ali, Bui, Kara, Pryzbylski, Amber, Roychowdhury, Sameek, Kulkarni, Shashikant, Griffith, Obi L., Griffith, Malachi, Selvarajah, Shamini

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Determining the Role of Discoidin Domain Receptors in the Pathogenesis of Pancreatic Ductal Adenocarcinoma by Ruggeri, Jeanine Marie

“…Pancreatic ductal adenocarcinoma (PDA) is an aggressive and devastating malignancy characterized by a collagen-rich, fibroinflammatory stroma. In the presence…”
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Microsomal Ca2+ flux modulation as an indicator of heavy metal toxicity by Pentyala, Srinivas, Ruggeri, Jeanine, Veerraju, Amulya, Yu, Zhangzhang, Bhatia, Anjori, Desaiah, Durisala, Vig, Parminder

“…Inositol 1,4,5-trisphosphatee (IP3), an intracellular messenger, releases Ca2+ from microsomes. Ca2+ plays a major role in regulating various cellular events…”
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The germline CDH1 c.48 G>C substitution contributes to cancer predisposition through generation of a pro-invasive mutation by Zhang, Liying, Xiao, Alexander, Ruggeri, Jeanine, Bacares, Ruben, Somar, Joshua, Melo, Soraia, Figueiredo, Joana, Simões-Correia, Joana, Seruca, Raquel, Shah, Manish A

“…Mutation screening of CDH1 is a standard of care for patients who meet criteria for Hereditary Diffuse Gastric Cancer (HDGC). In this setting, the…”
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Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in PancreatitisSummary by Christopher J. Halbrook, Hui-Ju Wen, Jeanine M. Ruggeri, Kenneth K. Takeuchi, Yaqing Zhang, Marina Pasca di Magliano, Howard C. Crawford

“…Background & Aims: Mitogen-activated protein kinase (MAPK) signaling in the exocrine pancreas has been extensively studied in the context of pancreatic cancer,…”
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