Search Results - "Ruff, William E"

Host–microbiota interactions in immune-mediated diseases by Ruff, William E., Greiling, Teri M., Kriegel, Martin A.

“…Host–microbiota interactions are fundamental for the development of the immune system. Drastic changes in modern environments and lifestyles have led to an…”
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Autoimmune host–microbiota interactions at barrier sites and beyond by Ruff, William E, Kriegel, Martin A

“…Highlights • Human barrier organs are constitutively colonized by trillions of microorganisms. • The microbiota affects innate and adaptive immune responses…”
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A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity by Zegarra-Ruiz, Daniel F., El Beidaq, Asmaa, Iñiguez, Alonso J., Lubrano Di Ricco, Martina, Manfredo Vieira, Silvio, Ruff, William E., Mubiru, Derek, Fine, Rebecca L., Sterpka, John, Greiling, Teri M., Dehner, Carina, Kriegel, Martin A.

“…Western lifestyle is linked to autoimmune and metabolic diseases, driven by changes in diet and gut microbiota composition. Using Toll-like receptor 7…”
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Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis by Asashima, Hiromitsu, Axisa, Pierre-Paul, Pham, Thi Hong Giang, Longbrake, Erin E, Ruff, William E, Lele, Nikhil, Cohen, Inessa, Raddassi, Khadir, Sumida, Tomokazu S, Hafler, David A

“…B cell depletion in patients with relapsing-remitting multiple sclerosis (RRMS) markedly prevents new MRI-detected lesions and disease activity, suggesting the…”
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The Role of the Gut Microbiota in the Pathogenesis of Antiphospholipid Syndrome by Ruff, William E., Vieira, Silvio M., Kriegel, Martin A.

“…Infectious triggers are associated with the induction of transient antiphospholipid antibodies. One therefore wonders if microbes that permanently colonize us…”
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CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome by Choileáin, Siobhán Ní, Kleinewietfeld, Markus, Raddassi, Khadir, Hafler, David A., Ruff, William E., Longbrake, Erin E.

“…Multiple sclerosis (MS) is a genetically mediated autoimmune disease characterized by inflammation in the central nervous system (CNS). Disease onset is…”
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Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions by Dehner, Carina A., Ruff, William E., Greiling, Teri, Pereira, Márcia S., Redanz, Sylvio, McNiff, Jennifer, Girardi, Michael, Kriegel, Martin A.

“…Cutaneous T-cell lymphoma (CTCL) is a life-debilitating malignancy of lymphocytes homing to the skin. Although CTCL is thought to arise from a combination of…”
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Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination by Asashima, Hiromitsu, Kim, Dongjoo, Wang, Kaicheng, Lele, Nikhil, Buitrago-Pocasangre, Nicholas C, Lutz, Rachel, Cruz, Isabella, Raddassi, Khadir, Ruff, William E, Racke, Michael K, Wilson, JoDell E, Givens, Tara S, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Kleinstein, Steven H, Montgomery, Ruth R, Shaw, Albert C, Li, Fangyong, Fan, Rong, Hafler, David A, Tomayko, Mary M, Longbrake, Erin E

“…BACKGROUNDWhile B cell depletion is associated with attenuated antibody responses to SARS-CoV-2 mRNA vaccination, responses vary among individuals. Thus,…”
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Influence of immunomodulatory drugs on the gut microbiota by Cohen, Inessa, Ruff, William E., Longbrake, Erin E.

“…Immunomodulatory medications are a mainstay of treatment for autoimmune diseases and malignancies. In addition to their direct effects on immune cells, these…”
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Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity by Ruff, William E., Dehner, Carina, Kim, Woo J., Pagovich, Odelya, Aguiar, Cassyanne L., Yu, Andrew T., Roth, Alexander S., Vieira, Silvio Manfredo, Kriegel, Christina, Adeniyi, Olamide, Mulla, Melissa J., Abrahams, Vikki M., Kwok, William W., Nussinov, Ruth, Erkan, Doruk, Goodman, Andrew L., Kriegel, Martin A.

“…Given the immense antigenic load present in the microbiome, we hypothesized that microbiota mimotopes can be a persistent trigger in human autoimmunity via…”
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Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19 by Unterman, Avraham, Sumida, Tomokazu S., Nouri, Nima, Yan, Xiting, Zhao, Amy Y., Gasque, Victor, Schupp, Jonas C., Asashima, Hiromitsu, Liu, Yunqing, Cosme, Carlos, Deng, Wenxuan, Chen, Ming, Raredon, Micha Sam Brickman, Hoehn, Kenneth B., Wang, Guilin, Wang, Zuoheng, DeIuliis, Giuseppe, Ravindra, Neal G., Li, Ningshan, Castaldi, Christopher, Wong, Patrick, Fournier, John, Bermejo, Santos, Sharma, Lokesh, Casanovas-Massana, Arnau, Vogels, Chantal B. F., Wyllie, Anne L., Grubaugh, Nathan D., Melillo, Anthony, Meng, Hailong, Stein, Yan, Minasyan, Maksym, Mohanty, Subhasis, Ruff, William E., Cohen, Inessa, Raddassi, Khadir, Niklason, Laura E., Ko, Albert I., Montgomery, Ruth R., Farhadian, Shelli F., Iwasaki, Akiko, Shaw, Albert C., van Dijk, David, Zhao, Hongyu, Kleinstein, Steven H., Hafler, David A., Kaminski, Naftali, Dela Cruz, Charles S.

“…Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe COVID-19. However, the immune signatures associated with immunopathology…”
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PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection by Asashima, Hiromitsu, Mohanty, Subhasis, Comi, Michela, Ruff, William E., Hoehn, Kenneth B., Wong, Patrick, Klein, Jon, Lucas, Carolina, Cohen, Inessa, Coffey, Sarah, Lele, Nikhil, Greta, Leissa, Raddassi, Khadir, Chaudhary, Omkar, Unterman, Avraham, Emu, Brinda, Kleinstein, Steven H., Montgomery, Ruth R., Iwasaki, Akiko, Dela Cruz, Charles S., Kaminski, Naftali, Shaw, Albert C., Hafler, David A., Sumida, Tomokazu S.

“…T cell-B cell interaction is the key immune response to protect the host from severe viral infection. However, how T cells support B cells to exert protective…”
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1504 The influence of dietary resistant starch content on the gut microbiota of patients with systemic lupus erythematosus and antiphospholipid syndrome by Kulyk, Iryna, Pereira, Marcia S, Redanz, Sylvio, Ruff, William E, Greiling, Teri M, Dehner, Carina, Pagovich, Odelya, Ruiz, Daniel Zegarra, Aguiar, Cassyanne L, Erkan, Doruk, Kriegel, Martin A

“…BackgroundDiets deficient in fibers are prevalent in modern societies and implicated in gut microbial dysbiosis contributing to the pathogenesis of chronic…”
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The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium by Hanna, Stephanie J, Bonami, Rachel H, Corrie, Brian, Westley, Monica, Posgai, Amanda L, Luning Prak, Eline T, Breden, Felix, Michels, Aaron W, Brusko, Todd M

“…Human molecular genetics has brought incredible insights into the variants that confer risk for the development of tissue-specific autoimmune diseases,…”
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PD-1 high CXCR5 - CD4 + peripheral helper T cells promote CXCR3 + plasmablasts in human acute viral infection by Asashima, Hiromitsu, Mohanty, Subhasis, Comi, Michela, Ruff, William E, Hoehn, Kenneth B, Wong, Patrick, Klein, Jon, Lucas, Carolina, Cohen, Inessa, Coffey, Sarah, Lele, Nikhil, Greta, Leissa, Raddassi, Khadir, Chaudhary, Omkar, Unterman, Avraham, Emu, Brinda, Kleinstein, Steven H, Montgomery, Ruth R, Iwasaki, Akiko, Dela Cruz, Charles S, Kaminski, Naftali, Shaw, Albert C, Hafler, David A, Sumida, Tomokazu S

“…T cell-B cell interaction is the key immune response to protect the host from severe viral infection. However, how T cells support B cells to exert protective…”
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Human gut microbiota and antiphospholipid syndrome: T and B cell cross-reactivity between the major autoantigen, beta 2-glycoprotein I, and Roseburia intestinalis by Ruff, William E

“…Commensal microbiota influence the development, homeostasis, and phenotype of the mammalian immune system. Mouse studies have demonstrated that individual…”
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