Search Results - "Ruf, Viktoria C."

Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes by Ghio, Stephanie, Camilleri, Angelique, Caruana, Mario, Ruf, Viktoria C, Schmidt, Felix, Leonov, Andrei, Ryazanov, Sergey, Griesinger, Christian, Cauchi, Ruben J, Kamp, Frits, Giese, Armin, Vassallo, Neville

“…Aggregation of the amyloid-forming α-synuclein (αS) protein is closely associated with the etiology of Parkinson’s disease (PD), the most common motor…”
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PSMA Expression in Glioblastoma as a Basis for Theranostic Approaches: A Retrospective, Correlational Panel Study Including Immunohistochemistry, Clinical Parameters and PET Imaging by Holzgreve, Adrien, Biczok, Annamaria, Ruf, Viktoria C, Liesche-Starnecker, Friederike, Steiger, Katja, Kirchner, Maximilian A, Unterrainer, Marcus, Mittlmeier, Lena, Herms, Jochen, Schlegel, Jürgen, Bartenstein, Peter, Tonn, Jörg-Christian, Albert, Nathalie L, Suchorska, Bogdana

“…The aim of the current study was to enlighten the evolution of prostate-specific membrane antigen (PSMA) expression in glioblastoma between initial diagnosis…”
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Healthcare-associated exposure to Borna disease virus 1 (BoDV-1) by Reinmiedl, Judith, Schulz, Heiko, Ruf, Viktoria C, Hernandez Petzsche, Moritz R, Rissland, Jürgen, Tappe, Dennis

“…The Borna disease virus 1 (BoDV-1) causes severe and often fatal encephalitis in humans. The virus is endemic in parts of Germany, Liechtenstein, Switzerland…”
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Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue by Tauber, Christina V, Schwarz, Sigrid C, Rösler, Thomas W, Arzberger, Thomas, Gentleman, Steve, Windl, Otto, Krumbiegel, Mandy, Reis, André, Ruf, Viktoria C, Herms, Jochen, Höglinger, Günter U

“…The MAPT gene, encoding the microtubule-associated protein tau on chromosome 17q21.31, is result of an inversion polymorphism, leading to two allelic variants…”
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PSMA PET Imaging in Glioblastoma: A Preclinical Evaluation and Theranostic Outlook by Kirchner, Maximilian A, Holzgreve, Adrien, Brendel, Matthias, Orth, Michael, Ruf, Viktoria C, Steiger, Katja, Pötter, Dennis, Gold, Lukas, Unterrainer, Marcus, Mittlmeier, Lena M, Barci, Enio, Kälin, Roland E, Glass, Rainer, Lindner, Simon, Kaiser, Lena, Maas, Jessica, von Baumgarten, Louisa, Ilhan, Harun, Belka, Claus, Notni, Johannes, Bartenstein, Peter, Lauber, Kirsten, Albert, Nathalie L

“…Prostate specific membrane antigen (PSMA) PET imaging has recently gained attention in glioblastoma (GBM) patients as a potential theranostic target for PSMA…”
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Travel-associated neurological disease terminated in a postmortem diagnosed atypical HSV-1 encephalitis after high-dose steroid therapy - a case report by Osterman, Andreas, Ruf, Viktoria C, Domingo, Cristina, Nitsche, Andreas, Eichhorn, Peter, Zimmermann, Hanna, Seelos, Klaus, Zange, Sabine, Dimitriadis, Konstantinos, Pfister, Hans-Walter, Thye, Thorsten, Giese, Armin, Tappe, Dennis, Böhm, Stephan

“…Human encephalitis can originate from a variety of different aetiologies, of which infection is the most common one. The diagnostic work-up is specifically…”
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Potential sources of interference with the highly sensitive detection and quantification of alpha‐synuclein seeds by qRT‐QuIC by Ruf, Viktoria C., Shi, Song, Schmidt, Felix, Weckbecker, Daniel, Nübling, Georg S., Ködel, Uwe, Mollenhauer, Brit, Giese, Armin

“…Parkinson’s disease (PD) is a progressive neurodegenerative disease which is histologically characterized by loss of dopaminergic neurons in the substantia…”
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Prediction of TERTp-mutation status in IDH-wildtype high-grade gliomas using pre-treatment dynamic [18F]FET PET radiomics by Li, Zhicong, Kaiser, Lena, Holzgreve, Adrien, Ruf, Viktoria C., Suchorska, Bogdana, Wenter, Vera, Quach, Stefanie, Herms, Jochen, Bartenstein, Peter, Tonn, Jörg-Christian, Unterrainer, Marcus, Albert, Nathalie L.

“…Purpose To evaluate radiomic features extracted from standard static images (20–40 min p.i.), early summation images (5–15 min p.i.), and dynamic [ 18 F]FET…”
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Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration by Briel, Nils, Ruf, Viktoria C., Pratsch, Katrin, Roeber, Sigrun, Widmann, Jeannine, Mielke, Janina, Dorostkar, Mario M., Windl, Otto, Arzberger, Thomas, Herms, Jochen, Struebing, Felix L.

“…Tauopathies such as progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) exhibit characteristic neuronal and glial inclusions of…”
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Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1 by Sievers, Philipp, Appay, Romain, Schrimpf, Daniel, Stichel, Damian, Reuss, David E., Wefers, Annika K., Reinhardt, Annekathrin, Coras, Roland, Ruf, Viktoria C., Schmid, Simone, de Stricker, Karin, Boldt, Henning B., Kristensen, Bjarne Winther, Petersen, Jeanette Krogh, Ulhøi, Benedicte P., Gardberg, Maria, Aronica, Eleonora, Hasselblatt, Martin, Brück, Wolfgang, Bielle, Franck, Mokhtari, Karima, Lhermitte, Benoît, Wick, Wolfgang, Herold-Mende, Christel, Hänggi, Daniel, Brandner, Sebastian, Giangaspero, Felice, Capper, David, Rushing, Elisabeth, Wesseling, Pieter, Pfister, Stefan M., Figarella-Branger, Dominique, von Deimling, Andreas, Sahm, Felix, Jones, David T. W.

“…Rosette-forming glioneuronal tumor (RGNT) is a rare brain neoplasm that primarily affects young adults. Although alterations affecting the mitogen-activated…”
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An 8‐Year‐Old Girl with Posterior Fossa Mass by Ruf, Viktoria C., Schöler, Anne, Capper, David, Arzberger, Thomas, Herms, Jochen, Schüller, Ulrich

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Combination of pre-treatment dynamic [18F]FET PET radiomics and conventional clinical parameters for the survival stratification in patients with IDH-wildtype glioblastoma by Li, Zhicong, Holzgreve, Adrien, Unterrainer, Lena M., Ruf, Viktoria C., Quach, Stefanie, Bartos, Laura M., Suchorska, Bogdana, Niyazi, Maximilian, Wenter, Vera, Herms, Jochen, Bartenstein, Peter, Tonn, Joerg-Christian, Unterrainer, Marcus, Albert, Nathalie L., Kaiser, Lena

“…Purpose The aim of this study was to build and evaluate a prediction model which incorporates clinical parameters and radiomic features extracted from static…”
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Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates by Deeg, Andreas A., Reiner, Anne M., Schmidt, Felix, Schueder, Florian, Ryazanov, Sergey, Ruf, Viktoria C., Giller, Karin, Becker, Stefan, Leonov, Andrei, Griesinger, Christian, Giese, Armin, Zinth, Wolfgang

“…Special diphenyl-pyrazole compounds and in particular anle138b were found to reduce the progression of prion and Parkinson's disease in animal models. The…”
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Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH-Wild-Type Glioblastoma by Albert, Nathalie L, Nelwan, Debie V, Fleischmann, Daniel F, Quach, Stefanie, von Rohr, Katharina, Kaiser, Lena, Teske, Nico, Unterrainer, Lena M, Bartos, Laura M, Ruf, Viktoria C, Brendel, Matthias, Riemenschneider, Markus J, Wetzel, Christian, Herms, Jochen, Rupprecht, Rainer, Thon, Niklas, Tonn, Joerg-Christian, Belka, Claus, Bartenstein, Peter, von Baumgarten, Louisa, Niyazi, Maximilian, Unterrainer, Marcus, Holzgreve, Adrien

“…The 18-kDa translocator protein (TSPO) is gaining recognition as a relevant target in glioblastoma imaging. However, data on the potential prognostic value of…”
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Different Effects of α‑Synuclein Mutants on Lipid Binding and Aggregation Detected by Single Molecule Fluorescence Spectroscopy and ThT Fluorescence-Based Measurements by Ruf, Viktoria C, Nübling, Georg S, Willikens, Sophia, Shi, Song, Schmidt, Felix, Levin, Johannes, Bötzel, Kai, Kamp, Frits, Giese, Armin

“…Six α-synuclein (aSyn) point mutations are currently known to be associated with familial parkinsonism: A30P, E46K, H50Q, G51D, A53E, and A53T. We performed a…”
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Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy by Blumenstock, Sonja, Angelo, Maria Florencia, Peters, Finn, Dorostkar, Mario M., Ruf, Viktoria C., Luckner, Manja, Crux, Sophie, Slapakova, Lenka, Arzberger, Thomas, Claverol, Stéphane, Herzog, Etienne, Herms, Jochen

“…Cognitive decline and dementia in neurodegenerative diseases are associated with synapse dysfunction and loss, which may precede neuron loss by several years…”
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Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome by Bartos, Laura M, Quach, Stefanie, Zenatti, Valerio, Kirchleitner, Sabrina V, Blobner, Jens, Wind-Mark, Karin, Kolabas, Zeynep Ilgin, Ulukaya, Selin, Holzgreve, Adrien, Ruf, Viktoria C, Kunze, Lea H, Kunte, Sebastian T, Hoermann, Leonie, Härtel, Marlies, Park, Ha Eun, Groß, Mattes, Franzmeier, Nicolai, Zatcepin, Artem, Zounek, Adrian, Kaiser, Lena, Riemenschneider, Markus J, Perneczky, Robert, Rauchmann, Boris-Stephan, Stöcklein, Sophia, Ziegler, Sibylle, Herms, Jochen, Ertürk, Ali, Tonn, Joerg C, Thon, Niklas, von Baumgarten, Louisa, Prestel, Matthias, Tahirovic, Sabina, Albert, Nathalie L, Brendel, Matthias

“…Current therapy strategies still provide only limited success in the treatment of glioblastoma, the most frequent primary brain tumor in adults. In addition to…”
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Impact of Magnetic Resonance Imaging Markers on the Diagnostic Performance of the International Parkinson and Movement Disorder Society Multiple System Atrophy Criteria by Jensen, Ida, Heine, Johanne, Ruf, Viktoria C., Compta, Yaroslau, Porcel, Laura Molina, Troakes, Claire, Vamanu, Albert, Downes, Sophia, Irwin, David, Cohen, Jesse, Lee, Edward B., Nilsson, Christer, Englund, Elisabet, Nemati, Mojtaba, Katzdobler, Sabrina, Levin, Johannes, Pantelyat, Alex, Seemiller, Joseph, Berger, Stephen, Swieten, John, Dopper, Elise, Rozenmuller, Annemieke, Kovacs, Gabor G., Bendahan, Nathaniel, Lang, Anthony E., Herms, Jochen, Höglinger, Günter, Hopfner, Franziska

“…Background Multiple system atrophy is a neurodegenerative disease with α‐synuclein aggregation in glial cytoplasmic inclusions, leading to dysautonomia,…”
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TSPO PET signal using [18F]GE180 is associated with survival in recurrent gliomas by Quach, Stefanie, Holzgreve, Adrien, Kaiser, Lena, Unterrainer, Marcus, Dekorsy, Franziska J., Nelwan, Debie V., Bartos, Laura M., Kirchleitner, Sabrina V., Weller, Jonathan, Weidner, Lorraine, Niyazi, Maximilian, Ruf, Viktoria C., Herms, Jochen, Stöcklein, Sophia, Wetzel, Christian, Riemenschneider, Markus J., v. Baumgarten, Louisa, Thon, Niklas, Brendel, Matthias, Rupprecht, Rainer, Bartenstein, Peter, Tonn, Joerg-Christian, Albert, Nathalie L.

“…Purpose Glioma patients, especially recurrent glioma, suffer from a poor prognosis. While advances to classify glioma on a molecular level improved…”
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Alpha-synuclein fragments trigger distinct aggregation pathways by Chakroun, Tasnim, Evsyukov, Valentin, Nykänen, Niko-Petteri, Höllerhage, Matthias, Schmidt, Andreas, Kamp, Frits, Ruf, Viktoria C., Wurst, Wolfgang, Rösler, Thomas W., Höglinger, Günter U.

“…Aggregation of alpha-synuclein (αSyn) is a crucial event underlying the pathophysiology of synucleinopathies. The existence of various intracellular and…”
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