Search Results - "Ruez, Richard"
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Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae
Published in Cell (04-02-2011)“…The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to…”
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118 Multimodal stratification of predictive biomarkers in head and neck cancers: a focus on cytokine-based immunotherapy
Published in Journal for immunotherapy of cancer (01-11-2023)“…BackgroundImmunotherapy, particularly cytokine-based therapy, has been gaining traction in the treatment of head and neck cancers. Cytokines are small proteins…”
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The NLRP6 protein is very faintly expressed in several normal and cancerous epithelial cells and may be confused with an unrelated protein
Published in PloS one (20-01-2023)“…Nod-Like Receptor Pyrin domain-containing protein 6 (NLRP6), a member of the Nucleotide-oligomerization domain-Like Receptor (NLR) family of proteins,…”
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Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens
Published in Nature communications (17-12-2018)“…Mutations in the nucleotide-binding oligomerization domain protein 12 (NLRP12) cause recurrent episodes of serosal inflammation. Here we show that NLRP12…”
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Connexins in respiratory and gastrointestinal mucosal immunity
Published in FEBS letters (17-04-2014)“…The mucosal lining forms the physical and chemical barrier that protects against pathogens and hostile particles and harbors its own population of bacteria,…”
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The colibactin-producing Escherichia coli alters the tumor microenvironment to immunosuppressive lipid overload facilitating colorectal cancer progression and chemoresistance
Published in Gut microbes (2024)“…Intratumoral bacteria flexibly contribute to cellular and molecular tumor heterogeneity for supporting cancer recurrence through poorly understood mechanisms…”
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Dendritic Cell Migration Toward CCL21 Gradient Requires Functional Cx43
Published in Frontiers in physiology (27-03-2018)“…Dendritic cells (DCs) travel through lymphatic vessels to transport antigens and present them to T cells in lymph nodes. DCs move directionally toward…”
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Endocytosis and toxicity of clostridial binary toxins depend on a clathrin‐independent pathway regulated by Rho‐GDI
Published in Cellular microbiology (01-01-2011)“…Summary Clostridial binary toxins, such as Clostridium perfringens Iota and Clostridium botulinum C2, are composed of a binding protein (Ib and C2II…”
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Abstract 2536: Multimodal stratification of predictive biomarkers in head and neck cancers: A focus on cytokine-based immunotherapy
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Background Immunotherapy, particularly cytokine-based therapy, has been gaining traction in the treatment of head and neck cancers. Cytokines are small…”
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Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation
Published in Cell (11-08-2016)“…Understanding how membrane nanoscale organization controls transmembrane receptors signaling activity remains a challenge. We studied interferon-γ receptor…”
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Abstract 4629: Heterogeneity in glioblastoma tumor microenvironment: Opportunities for new therapies
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Background: Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by a poorly accessible microenvironment that render it…”
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Shear Forces Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia
Published in Circulation research (27-10-2023)“…Thrombocytopenia has been consistently described in patients with extracorporeal membrane oxygenation (ECMO) and associated with poor outcome. However, the…”
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Shear Force-Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia
Published in Circulation research (27-10-2023)“…BACKGROUND: Thrombocytopenia has been consistently described in patients with extracorporeal membrane oxygenation (ECMO) and associated with poor outcome…”
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Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae
Published in Cell (01-02-2011)Get full text
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