Search Results - "Ruela, André Luís Morais"
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Evaluation of skin absorption of drugs from topical and transdermal formulations
Published in Brazilian Journal of Pharmaceutical Sciences (01-09-2016)“…The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous…”
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Adsorption and release of nicotine from imprinted particles synthesised by precipitation polymerisation: Optimising transdermal formulations
Published in European polymer journal (01-03-2018)“…[Display omitted] •Nicotine adsorption in the polymer particles was better fitted to Langmuir-Freundlich isotherm.•MIP-2 showed higher selective adsorption of…”
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Mucoadhesive nanostructured lipid carriers as a cannabidiol nasal delivery system for the treatment of neuropathic pain
Published in European journal of pharmaceutical sciences (01-04-2021)“…The therapeutic potential of cannabidiol (CBD) has been explored to treat several pathologies, including those in which pain is prevalent. However, the oral…”
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The liquid crystalline phase behaviour of a nasal formulation modifies the brain disposition of donepezil in rats in the treatment of Alzheimer's disease
Published in Colloids and surfaces, B, Biointerfaces (01-07-2021)“…[Display omitted] •A microemulsion (ME) for the intranasal delivery of donepezil was obtained.•The ME undergoes an in situ phase transition to a mucoadhesive…”
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Preparation and sensory evaluation of gels based on silicone copolymers/acrylic copolymers incorporating different vegetable oils
Published in Industrial crops and products (01-03-2023)“…Fixed vegetable oil is one of the most used plant derivatives for cosmetic application, especially in skin products, due to its fatty acid composition, which…”
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Exploring the Phase Behavior of Monoolein/Oleic Acid/Water Systems for Enhanced Donezepil Administration for Alzheimer Disease Treatment
Published in Journal of pharmaceutical sciences (01-01-2016)“…Donepezil is a drug usually administered by oral route for Alzheimer disease treatment, but several gastric side effects have been reported as diarrhea,…”
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Biopharmaceutics considerations for direct oral anticoagulants
Published in Drug development and industrial pharmacy (02-12-2021)“…Vitamin K antagonists (VKA) and direct oral anticoagulants (DOACs) have been clinically used in the treatment of coagulation disorders. There are four DOACs…”
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Molecularly imprinted microparticles in lipid-based formulations for sustained release of donepezil
Published in European journal of pharmaceutical sciences (10-10-2016)“…Donepezil is a drug administered for Alzheimer's disease treatment, and it is a potential template molecule for imprinted microparticles. The precipitation…”
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Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review
Published in Critical reviews in analytical chemistry (04-07-2018)“…Rosuvastatin calcium (ROS), ( Figure 1 ) belongs to the "statins" group, which is the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This…”
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Molecularly imprinted polymers as nicotine transdermal delivery systems
Published in Chemical engineering journal (Lausanne, Switzerland : 1996) (15-07-2014)“…[Display omitted] •The feasibility of MIPs was evaluated as carriers for nicotine delivery in the skin.•The drug–polymer interactions were established between…”
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Evaluating the discriminatory power of a dissolution assay for rosuvastatin calcium capsules: Solid-state properties and dissolution media
Published in Brazilian Journal of Pharmaceutical Sciences (2019)“…We propose to evaluate the dissolution properties of rosuvastatin calcium (ROSC) capsules in different media to characterize the discriminatory power of the…”
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Analysis of spironolactone polymorphs in active pharmaceutical ingredients and their effect on tablet dissolution profiles
Published in Brazilian Journal of Pharmaceutical Sciences (01-10-2016)“…Spironolactone (SPR) is a steroidal drug administered as a potassium-sparing diuretic for high blood pressure treatment. The drug shows incomplete…”
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In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil
Published in Brazilian Journal of Pharmaceutical Sciences (01-09-2013)“…The aim of this study was to develop and validate a method for evaluating the release and skin permeation from transdermal nicotine patches using the vertical…”
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Pharmacokinetics and pharmacodynamics of glimepiride polymorphs
Published in International journal of pharmaceutics (20-12-2018)“…[Display omitted] Glimepiride (GLIM) is used as an oral antihyperglycemic agent for treatment of type 2 diabetes. The drug presents two polymorphic forms (GLIM…”
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Desenvolvimento e validação de um método analítico rápido por cromatografia líquida de alta eficiência para determinação de nimesulida em estudos de liberação in vitro Development and validation of a rapid analytical method by HPLC for determination of nimesulide in release studies
Published in Química nova (01-01-2009)“…A high performance liquid chromatography (HPLC) method has been developed for a rapid determination of nimesulide in dissolution studies. Nimesulide was…”
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