Search Results - "Ruehr, Mary L"
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Atrial Glutathione Content, Calcium Current, and Contractility
Published in The Journal of biological chemistry (21-09-2007)“…Atrial fibrillation (AF) is characterized by decreased L-type calcium current (ICa,L) in atrial myocytes and decreased atrial contractility. Oxidant stress and…”
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A-kinase anchoring protein targeting of protein kinase A in the heart
Published in Journal of molecular and cellular cardiology (01-09-2004)“…There is increasing evidence that subcellular targeting of signaling molecules is an important means of regulating the protein kinase A (PKA) pathway…”
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Targeting of Protein Kinase A by Muscle A Kinase-anchoring Protein (mAKAP) Regulates Phosphorylation and Function of the Skeletal Muscle Ryanodine Receptor
Published in The Journal of biological chemistry (04-07-2003)“…Protein kinase A anchoring proteins (AKAPs) tether cAMP-dependent protein kinase (PKA) to specific subcellular locations. The muscle AKAP, mAKAP, co-localizes…”
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Effects of sterile pericarditis on connexins 40 and 43 in the atria: correlation with abnormal conduction and atrial arrhythmias
Published in American journal of physiology. Heart and circulatory physiology (01-08-2007)“…The canine sterile pericarditis model is characterized by impaired conduction and atrial arrhythmia vulnerability. Electrical and structural remodeling…”
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ANG II-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells
Published in The American journal of physiology (01-01-1998)“…The accumulation of radiolabeled arachidonic acid (AA), immunoblot analysis of subcellular fractions, and immunofluorescence tagging of proteins in intact…”
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Selectivity and Regulation of A-kinase Anchoring Proteins in the Heart
Published in The Journal of biological chemistry (29-12-2000)“…Downstream regulation of the cAMP-dependent protein kinase (PKA) pathway is mediated by anchoring proteins (AKAPs) that sequester PKA to specific subcellular…”
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Abstract 1525: Atrial Rhythm Acutely Modulates Connexin43 Expression and Phosphorylation State in Human Atrial Fibrillation
Published in Circulation (New York, N.Y.) (28-10-2008)“…Abstract only Background: Adjacent areas of heterogenous conduction in the atria form a substrate for atrial fibrillation (AF). Connexin proteins (Cx) underlie…”
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Effects of RII Phosphorylation on Protein Kinase A targeting in the Heart
Published in The FASEB journal (01-03-2006)“…A Kinase Anchoring proteins (AKAPs) regulate the Protein Kinase A (PKA) signaling pathway by sequestering PKA close to substrates thereby facilitating…”
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Selectivity and regulation of A-kinase anchoring proteins in the heart. The role of autophosphorylation of the type II regulatory subunit of cAMP-dependent protein kinase
Published in The Journal of biological chemistry (29-12-2000)“…Downstream regulation of the cAMP-dependent protein kinase (PKA) pathway is mediated by anchoring proteins (AKAPs) that sequester PKA to specific subcellular…”
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Journal Article