Prophylactic use of antibiotics for nonlaboring patients undergoing cesarean delivery with intact membranes: A meta-analysis

Prophylactic use of antibiotics for nonlaboring patients undergoing cesarean delivery with intact membranes: A meta-analysis

Objective: We performed a meta-analysis to examine the role of antibiotic prophylaxis in preventing postoperative infections among nonlaboring women undergoing cesarean delivery with intact membranes. Study Design: A computerized literature search was performed with MEDLINE. Studies were included if...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology Vol. 184; no. 4; pp. 656 - 661
Main Authors: Chelmow, David, Ruehli, Monica S., Huang, Edwin
Format: Journal Article
Language:English
Published: Philadelphia, PA Elsevier Inc 01-03-2001
Elsevier
Subjects:
Antibacterial agents
Antibiotic Prophylaxis
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cesarean delivery complications
Cesarean Section
Endometritis - prevention & control
Female
Fever - prevention & control
Humans
Medical sciences
MEDLINE
meta-analysis
Odds Ratio
Pharmacology. Drug treatments
Postoperative Complications - prevention & control
Pregnancy
prophylactic antibiotic use
Randomized Controlled Trials as Topic
Surgical Wound Infection - prevention & control
meta-analysis
prophylactic antibiotic use
Cesarean delivery complications
Human
Postoperative
Metaanalysis
Infection
Prevention
Antibiotic
Chemotherapy
Medical prescription
Surgery
Complication
Female
Fetoplacental membrane
Cesarean section
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Summary:Objective: We performed a meta-analysis to examine the role of antibiotic prophylaxis in preventing postoperative infections among nonlaboring women undergoing cesarean delivery with intact membranes. Study Design: A computerized literature search was performed with MEDLINE. Studies were included if they contained data on patients undergoing cesarean delivery in the absence of labor and ruptured membranes. Only randomized trials with a placebo control group were included. Results: Seven studies were found. Use of antibiotics decreased the risk of all infectious outcomes reported. When the results of 4 studies were pooled, prophylactic antibiotic use was associated with a significant reduction in postoperative fever (relative risk, 0.25; 95% confidence interval, 0.14-0.44). A similar reduction was noted for endometritis in 4 studies (relative risk, 0.05; 95% confidence interval, 0.01-0.38). Two studies reported on wound infection and showed a trend toward a protective effect (relative risk, 0.59; 95% confidence interval, 0.24-1.45). Conclusion: The prophylactic use of antibiotics reduces the risk of postoperative infectious complications after cesarean delivery even in the population at lowest risk. (Am J Obstet Gynecol 2001;184:656-61.)
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2001.111303