Search Results - "Ruegg, Markus"

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting by Tintignac, Lionel A, Brenner, Hans-Rudolf, Rüegg, Markus A

“…The neuromuscular junction is the chemical synapse between motor neurons and skeletal muscle fibers. It is designed to reliably convert the action potential…”
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LncRNA-encoded peptides： More than translational noise by Rion, Nathalie, Rüegg, Markus A

“…Long non-coding RNAs （lncRNAs） belong to the ever-increasing number of transcripts that are thought not to encode proteins. A recent study has now identified a…”
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Laminin-deficient muscular dystrophy: Molecular pathogenesis and structural repair strategies by Yurchenco, Peter D., McKee, Karen K., Reinhard, Judith R., Rüegg, Markus A.

“…Laminins are large heterotrimers composed of the α, β and γ subunits with distinct tissue-specific and developmentally regulated expression patterns. The…”
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Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing by Blandino-Rosano, Manuel, Barbaresso, Rebecca, Jimenez-Palomares, Margarita, Bozadjieva, Nadejda, Werneck-de-Castro, Joao Pedro, Hatanaka, Masayuki, Mirmira, Raghavendra G., Sonenberg, Nahum, Liu, Ming, Rüegg, Markus A., Hall, Michael N., Bernal-Mizrachi, Ernesto

“…Deregulation of mTOR complex 1 (mTORC1) signalling increases the risk for metabolic diseases, including type 2 diabetes. Here we show that β-cell-specific loss…”
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mTOR controls embryonic and adult myogenesis via mTORC1 by Rion, Nathalie, Castets, Perrine, Lin, Shuo, Enderle, Leonie, Reinhard, Judith R, Eickhorst, Christopher, Rüegg, Markus A

“…The formation of multi-nucleated muscle fibers from progenitors requires the fine-tuned and coordinated regulation of proliferation, differentiation and…”
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mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 by Castets, Perrine, Rion, Nathalie, Théodore, Marine, Falcetta, Denis, Lin, Shuo, Reischl, Markus, Wild, Franziska, Guérard, Laurent, Eickhorst, Christopher, Brockhoff, Marielle, Guridi, Maitea, Ibebunjo, Chikwendu, Cruz, Joseph, Sinnreich, Michael, Rudolf, Rüdiger, Glass, David J., Rüegg, Markus A.

“…Loss of innervation of skeletal muscle is a determinant event in several muscle diseases. Although several effectors have been identified, the pathways…”
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Collagen XIII Is Required for Neuromuscular Synapse Regeneration and Functional Recovery after Peripheral Nerve Injury by Zainul, Zarin, Heikkinen, Anne, Koivisto, Hennariikka, Rautalahti, Iina, Kallio, Mika, Lin, Shuo, Härönen, Heli, Norman, Oula, Rüegg, Markus A, Tanila, Heikki, Pihlajaniemi, Taina

“…Collagen XIII occurs as both a transmembrane-bound and a shed extracellular protein and is able to regulate the formation and function of neuromuscular…”
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Neuronal LRP4 regulates synapse formation in the developing CNS by Karakatsani, Andromachi, Marichal, Nicolás, Urban, Severino, Kalamakis, Georgios, Ghanem, Alexander, Schick, Anna, Zhang, Yina, Conzelmann, Karl-Klaus, Rüegg, Markus A, Berninger, Benedikt, Ruiz de Almodovar, Carmen, Gascón, Sergio, Kröger, Stephan

“…The low-density lipoprotein receptor-related protein 4 (LRP4) is essential in muscle fibers for the establishment of the neuromuscular junction. Here, we show…”
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Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia by Börsch, Anastasiya, Ham, Daniel J., Mittal, Nitish, Tintignac, Lionel A., Migliavacca, Eugenia, Feige, Jérôme N., Rüegg, Markus A., Zavolan, Mihaela

“…Sarcopenia, the age-related loss of skeletal muscle mass and function, affects 5–13% of individuals aged over 60 years. While rodents are widely-used model…”
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Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction by Hettwer, Stefan, Lin, Shuo, Kucsera, Stefan, Haubitz, Monika, Oliveri, Filippo, Fariello, Ruggero G, Ruegg, Markus A, Vrijbloed, Jan W

“…Treatment of neuromuscular diseases is still an unsolved problem. Evidence over the last years strongly indicates the involvement of malformation and…”
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The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory by Reinhard, Judith R., Kriz, Alexander, Galic, Milos, Angliker, Nico, Rajalu, Mathieu, Vogt, Kaspar E., Ruegg, Markus A.

“…Hippocampal long-term potentiation (LTP) represents the cellular response of excitatory synapses to specific patterns of high neuronal activity and is required…”
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Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases by Punga, Anna Rostedt, Ruegg, Markus A

“…Highlights ► The neuromuscular junction (NMJ) as a highly reliable synapse. ► Formation and maintenance of the NMJ as a coordinated and interactive process. ►…”
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mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation by Fitter, Stephen, Matthews, Mary P., Martin, Sally K., Xie, Jianling, Ooi, Soo Siang, Walkley, Carl R., Codrington, John D., Ruegg, Markus A., Hall, Michael N., Proud, Christopher G., Gronthos, Stan, Zannettino, Andrew C. W.

“…The mammalian target of rapamycin complex 1 (mTORC1) is activated by extracellular factors that control bone accrual. However, the direct role of this complex…”
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Mammalian animal models for Duchenne muscular dystrophy by Willmann, Raffaella, Possekel, Stefanie, Dubach-Powell, Judith, Meier, Thomas, Ruegg, Markus A

“…Abstract Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease that affects boys and leads to early death. In the quest for new treatments that…”
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Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy by Boido, Marina, De Amicis, Elena, Valsecchi, Valeria, Trevisan, Marco, Ala, Ugo, Ruegg, Markus A, Hettwer, Stefan, Vercelli, Alessandro

“…Spinal muscular atrophy (SMA) is a pediatric genetic disease, characterized by motor neuron (MN) death, leading to progressive muscle weakness, respiratory…”
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Nerve pathology is prevented by linker proteins in mouse models for LAMA2 -related muscular dystrophy by Reinhard, Judith R, Porrello, Emanuela, Lin, Shuo, Pelczar, Pawel, Previtali, Stefano C, Rüegg, Markus A

“…-related muscular dystrophy (LAMA2 MD or MDC1A) is a devastating congenital muscular dystrophy that is caused by mutations in the gene encoding laminin-α2, the…”
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mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress by Grahammer, Florian, Haenisch, Nora, Steinhardt, Frederic, Sandner, Lukas, Sander, Lukas, Roerden, Malte, Arnold, Frederic, Cordts, Tomke, Wanner, Nicola, Reichardt, Wilfried, Kerjaschki, Dontscho, Ruegg, Markus A, Hall, Michael N, Moulin, Pierre, Busch, Hauke, Boerries, Melanie, Walz, Gerd, Artunc, Ferruh, Huber, Tobias B

“…Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell metabolism and autophagy. Despite widespread clinical use of mTORC1 inhibitors, the…”
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Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation by Martin, Sally K., Fitter, Stephen, Dutta, Ankit K., Matthews, Mary P., Walkley, Carl R., Hall, Michael N., Ruegg, Markus A., Gronthos, Stan, Zannettino, Andrew C. W.

“…Adipocytes (AdCs) and osteoblasts (OBs) are derived from mesenchymal stem cells (MSCs) and differentiation toward either lineage is both mutually exclusive and…”
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New insights into the roles of agrin by Ruegg, Markus A, Bezakova, Gabriela

“…The heparan sulphate proteoglycan agrin is expressed as several isoforms in various tissues. Agrin is best known as a crucial organizer of postsynaptic…”
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Editorial: Current Insights Into LAMA2 Disease by Previtali, Stefano C., Cohn, Ronald D., Ruegg, Markus A.

“…The disease has an estimated prevalence in UK and Italy of 0.6–0.7/100,000, and is characterized by a severe wasting muscular dystrophy, dysmyelinating…”
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