Search Results - "Rudy, J"
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Using the dynamic bond to access macroscopically responsive structurally dynamic polymers
Published in Nature materials (01-01-2011)“…In chemistry, some dynamic bonds can be selectively and reversibly broken and reformed in response to an environmental stimulus. This Review article discusses…”
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Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges
Published in Journal of Alzheimer's disease (01-01-2019)“…There is considerable interest in the pathobiology of tau protein, given its potential role in neurodegenerative diseases and aging. Tau is an important…”
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The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation
Published in Laboratory investigation (01-07-2019)“…The identification of amyloid-β precursor protein (APP) pathogenic mutations in familial early onset Alzheimer's disease (AD), along with knowledge that…”
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From siphonophores to deep scattering layers: uncertainty ranges for the estimation of global mesopelagic fish biomass
Published in ICES journal of marine science (01-05-2019)“…Abstract The mesopelagic community is important for downward oceanic carbon transportation and is a potential food source for humans. Estimates of global…”
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The complexities of the pathology–pathogenesis relationship in Alzheimer disease
Published in Biochemical pharmacology (15-04-2014)“…Current pathogenic theories for Alzheimer disease (AD) and aging favor the notion that lesions and their constituent proteins are the initiators of disease due…”
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Recombinant Probes for Visualizing Endogenous Synaptic Proteins in Living Neurons
Published in Neuron (Cambridge, Mass.) (19-06-2013)“…The ability to visualize endogenous proteins in living neurons provides a powerful means to interrogate neuronal structure and function. Here we…”
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Poly[n]catenanes: Synthesis of molecular interlocked chains
Published in Science (American Association for the Advancement of Science) (15-12-2017)“…As the macromolecular version of mechanically interlocked molecules, mechanically interlocked polymers are promising candidates for the creation of…”
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Predicting material release during a nuclear reactor accident
Published in Nature materials (01-03-2015)“…In the aftermath of a nuclear reactor accident, understanding the release of fission products from the fuel is key…”
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Acoustic biomass estimation of mesopelagic fish: backscattering from individuals, populations, and communities
Published in ICES journal of marine science (01-06-2015)“…Abstract Acoustic survey methods are useful to estimate the distribution, abundance, and biomass of mesopelagic fish, a key component of open ocean ecosystems…”
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An optimization‐based phase‐field method for continuous‐discontinuous crack propagation
Published in International journal for numerical methods in engineering (05-10-2018)“…Summary A new continuous‐discontinuous strategy for the computational modeling of crack propagation within the context of phase‐field models of fracture is…”
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Quantum Chemical Calculations and Experimental Investigations of Molecular Actinide Oxides
Published in Chemical reviews (25-02-2015)“…Kovacs et al explore quantum chemical calculations and experimental investigations of molecular actinide oxides. In their analysis, they focus on topics such…”
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The Amyloid Cascade Hypothesis: A Conclusion in Search of Support
Published in The American journal of pathology (10-11-2024)“…The amyloid cascade hypothesis as the etiological underpinning of Alzheimer's disease (AD) is supported by a large body of literature, the most influential of…”
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Saturated Fatty Acid-Induced Endoplasmic Reticulum Stress and Insulin Resistance Are Prevented by Imoxin in C2C12 Myotubes
Published in Frontiers in physiology (22-07-2022)“…In obesity, plasma free fatty acids (FFAs) levels are elevated due to enlarged adipose tissue mass. Saturated fatty acids can induce prolonged ER stress and…”
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A critical review of chronic traumatic encephalopathy
Published in Neuroscience and biobehavioral reviews (01-09-2015)“…Chronic traumatic encephalopathy (CTE) has been described in the literature as a neurodegenerative disease with: (i) localized neuronal and glial accumulations…”
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Reproducibility and normalization of reactive hyperemia using laser speckle contrast imaging
Published in PloS one (07-01-2021)“…Impaired perfusion indices signal potential microvascular dysfunction preceding atherosclerosis and other cardiometabolic pathologies. Post-occlusive reactive…”
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The Significance of Tau Aggregates in the Human Brain
Published in Brain sciences (11-12-2020)“…Neurofibrillary degeneration has attracted the attention of neuroscientists as both a hallmark of the disease and a subject for experimentation for more than a…”
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Pathogenesis and Disease-modifying Therapy in Alzheimer's Disease: The Flat Line of Progress
Published in Archives of medical research (01-11-2012)“…The lack of progress in the development of disease-modifying therapy in Alzheimer's disease (AD) was highlighted recently by the cessation of a phase 3…”
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Greater tolerance for nuclear materials
Published in Nature materials (01-09-2008)“…As interest in new generations of nuclear reactors is increasing worldwide, renewed research effort into new materials more tolerant to extreme conditions is…”
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Reducing bias due to noise and attenuation in open-ocean echo integration data
Published in ICES journal of marine science (01-10-2015)“…Abstract Measurements of mean volume backscattering strength (Sv, dB re 1 m−1) at ocean-basin scale were made using 38-kHz hull-mounted echosounders on ships…”
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