Search Results - "Rudraraju, Rajeev"

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids by Vanslambrouck, Jessica M., Wilson, Sean B., Tan, Ker Sin, Groenewegen, Ella, Rudraraju, Rajeev, Neil, Jessica, Lawlor, Kynan T., Mah, Sophia, Scurr, Michelle, Howden, Sara E., Subbarao, Kanta, Little, Melissa H.

“…While pluripotent stem cell-derived kidney organoids are now being used to model renal disease, the proximal nephron remains immature with limited evidence for…”
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Passive immunization with influenza haemagglutinin specific monoclonal antibodies by Rudraraju, Rajeev, Subbarao, Kanta

“…The isolation of broadly neutralising antibodies against the influenza haemagglutinin has spurred investigation into their clinical potential, and has led to…”
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Respiratory syncytial virus human experimental infection model: provenance, production, and sequence of low-passaged memphis-37 challenge virus by Kim, Young-In, DeVincenzo, John P, Jones, Bart G, Rudraraju, Rajeev, Harrison, Lisa, Meyers, Rachel, Cehelsky, Jeff, Alvarez, Rene, Hurwitz, Julia L

“…Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in children and is responsible for as many as 199,000 childhood…”
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Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A by Rudraraju, Rajeev, Jones, Bart G, Surman, Sherri L, Sealy, Robert E, Thomas, Paul G, Hurwitz, Julia L

“…Morbidity and mortality due to viral infections are major health concerns, particularly when individuals are vitamin A deficient. Vitamin A deficiency…”
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Reduced Frequencies and Heightened CD103 Expression among Virus-Induced CD8+ T Cells in the Respiratory Tract Airways of Vitamin A-Deficient Mice by Rudraraju, Rajeev, Surman, Sherri L, Jones, Bart G, Sealy, Robert, Woodland, David L, Hurwitz, Julia L

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Respiratory syncytial virus: current progress in vaccine development by Rudraraju, Rajeev, Jones, Bart G, Sealy, Robert, Surman, Sherri L, Hurwitz, Julia L

“…Respiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths…”
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Convalescent plasma treatment for COVID‐19: Tempering expectations with the influenza experience by Subbarao, Kanta, Mordant, Francesca, Rudraraju, Rajeev

“…The COVID‐19 pandemic caused by the zoonotic coronavirus, SARS‐CoV‐2 has swept the world in 5 months. A proportion of cases develop severe respiratory tract…”
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How Live Attenuated Vaccines Can Inform the Development of Broadly Cross-Protective Influenza Vaccines by Rudraraju, Rajeev, Mordant, Francesca, Subbarao, Kanta

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Maturation-Enhanced Proximal Tubules Enable Functionality, Toxicity Screening, and Infectious Disease Modeling in Kidney Organoids: PO0641 by Vanslambrouck, Jessica M., Tan, Ker sin, Wilson, Sean, Groenewegen, Ella, Neil, Jessica A., Rudraraju, Rajeev, Scurr, Michelle, Howden, Sara E., Subbarao, Kanta, Little, Melissa H.

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Kidney organoids reveal redundancy in viral entry pathways during ACE2-dependent SARS-CoV-2 infection by Vanslambrouck, Jessica M, Neil, Jessica A, Rudraraju, Rajeev, Mah, Sophia, Tan, Ker Sin, Groenewegen, Ella, Forbes, Thomas A, Karavendzas, Katerina, Elliott, David A, Porrello, Enzo R, Subbarao, Kanta, Little, Melissa H

“…With a high incidence of acute kidney injury among hospitalized COVID-19 patients, considerable attention has been focussed on whether SARS-CoV-2 specifically…”
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Sendai virus-based RSV vaccine protects African green monkeys from RSV infection by Jones, Bart G, Sealy, Robert E, Rudraraju, Rajeev, Traina-Dorge, Vicki L, Finneyfrock, Brad, Cook, Anthony, Takimoto, Toru, Portner, Allen, Hurwitz, Julia L

“…Highlights ► SeVRSV, a recombinant Sendai virus expressing RSV F, was tested in AGM. ► SeVRSV elicited antibody responses against SeV and RSV. ► SeVRSV fully…”
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De novo design of CRISPR-Cas13b enables efficient silencing of SARS-CoV-2 variants and tumour pathogenic RNAs with near single-base precision by Hu, Wenxin, Zhao, Wei, Kumar, Amit, Singh, Gurjeet Jagjeet, Qi, Shijiao, Casan, Josh, Shembery, Carolyn, Fong, Danielle, Zerbato, Jennifer M., Symons, Jori, Rudraraju, Rajeev, Purcell, Damian, Haber, Michelle, Voskoboinik, Ilia, Ekert, Paul G., Lewin, Sharon, Trapani, Joseph, Fareh, Mohamed

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Antibody titres elicited by the 2018 seasonal inactivated influenza vaccine decline by 3 months post‐vaccination but persist for at least 6 months by Mordant, Francesca L., Price, Olivia H., Rudraraju, Rajeev, Slavin, Monica A., Marshall, Caroline, Worth, Leon J., Peck, Heidi, Barr, Ian G., Sullivan, Sheena G., Subbarao, Kanta

“…Background In Australia, seasonal inactivated influenza vaccine is typically offered in April. However, the onset, peak and end of a typical influenza season…”
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Intranasal administration of retinyl palmitate with a respiratory virus vaccine corrects impaired mucosal IgA response in the vitamin A-deficient host by Surman, Sherri L, Jones, Bart G, Rudraraju, Rajeev, Sealy, Robert E, Hurwitz, Julia L

“…Our previous studies showed that intranasal vaccination of vitamin A-deficient (VAD) mice failed to induce normal levels of upper respiratory tract IgA, a…”
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Phenotypes and functions of persistent Sendai virus-induced antibody forming cells and CD8+ T cells in diffuse nasal-associated lymphoid tissue typify lymphocyte responses of the gut by Rudraraju, Rajeev, Surman, Sherri, Jones, Bart, Sealy, Robert, Woodland, David L, Hurwitz, Julia L

“…Abstract Lymphocytes of the diffuse nasal-associated lymphoid tissue (d-NALT) are uniquely positioned to tackle respiratory pathogens at their point-of-entry,…”
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Antigen presenting cell‐targeted proinsulin expression converts insulin‐specific CD8+ T‐cell priming to tolerance in autoimmune‐prone NOD mice by Reeves, Peta L. S., Rudraraju, Rajeev, Wong, F. Susan, Hamilton‐Williams, Emma E., Steptoe, Raymond J.

“…Type 1 diabetes (T1D) results from autoimmune destruction of insulin‐producing pancreatic β cells. Therapies need to incorporate strategies to overcome the…”
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Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment by Rudraraju, Rajeev, Gartner, Matthew J., Neil, Jessica A., Stout, Elizabeth S., Chen, Joseph, Needham, Elise J., See, Michael, Mackenzie-Kludas, Charley, Yang Lee, Leo Yi, Wang, Mingyang, Pointer, Hayley, Karavendzas, Kathy, Abu-Bonsrah, Dad, Drew, Damien, Yang Sun, Yu Bo, Tan, Jia Ping, Sun, Guizhi, Salavaty, Abbas, Charitakis, Natalie, Nim, Hieu T., Currie, Peter D., Tham, Wai-Hong, Porrello, Enzo, Polo, Jose M., Humphrey, Sean J., Ramialison, Mirana, Elliott, David A., Subbarao, Kanta

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily infects the respiratory tract, but pulmonary and cardiac complications occur in severe…”
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Deciphering and correcting impaired respiratory virus-specific immunity caused by vitamin A deficiency (VIR2P.1017) by Penkert, Rhiannon, Surman, Sherri, Jones, Bart, Sealy, Robert, Neale, Geoffrey, Rudraraju, Rajeev, Hurwitz, Julia

“…Abstract Vitamin A deficiency (VAD) is a leading contributor to pediatric morbidity and mortality worldwide. Recently we have shown that VAD in mice impairs…”
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Single-shot immunization with recombinant adenovirus encoding vaccinia virus glycoprotein A27L is protective against a virulent respiratory poxvirus infection by Rudraraju, Rajeev, Ramsay, Alistair J

“…Abstract Significant safety issues have emerged concerning the general use of DRYVAX® vaccine. Vaccination with replication-defective recombinant adenovirus…”
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