Search Results - "Rudolph, Johannes"

Inhibitors of PARP: Number crunching and structure gazing by Rudolph, Johannes, Jung, Karen, Luger, Karolin

“…SignificancePARP is an important target in the treatment of cancers, particularly in patients with breast, ovarian, or prostate cancer that have compromised…”
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Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs by Rudolph, Johannes, Roberts, Genevieve, Luger, Karolin

“…Poly-(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) are key enzymes in the DNA damage response. Four different inhibitors (PARPi) are currently in the…”
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HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase by Rudolph, Johannes, Roberts, Genevieve, Muthurajan, Uma M, Luger, Karolin

“…Poly(ADP-ribose) polymerase 1 (PARP1) is an important player in the response to DNA damage. Recently, Histone PARylation Factor (HPF1) was shown to be a…”
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Poly(ADP-ribose) polymerase 1 searches DNA via a 'monkey bar' mechanism by Rudolph, Johannes, Mahadevan, Jyothi, Dyer, Pamela, Luger, Karolin

“…Poly(ADP-ribose) polymerase 1 (PARP1) is both a first responder to DNA damage and a chromatin architectural protein. How PARP1 rapidly finds DNA damage sites…”
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Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1 by Gaullier, Guillaume, Roberts, Genevieve, Muthurajan, Uma M, Bowerman, Samuel, Rudolph, Johannes, Mahadevan, Jyothi, Jha, Asmita, Rae, Purushka S, Luger, Karolin

“…Poly(ADP-ribose) Polymerase 2 (PARP2) is one of three DNA-dependent PARPs involved in the detection of DNA damage. Upon binding to DNA double-strand breaks,…”
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The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding by Bennett, Jeremy A, Steward, Lottie R, Rudolph, Johannes, Voss, Adam P, Aydin, Halil

“…Mitochondria are complex organelles that play a central role in metabolism. Dynamic membrane-associated processes regulate mitochondrial morphology and…”
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Investigating the Dynamics of Destabilized Nucleosomes Using Methyl-TROSY NMR by Kitevski-LeBlanc, Julianne L, Yuwen, Tairan, Dyer, Pamela N, Rudolph, Johannes, Luger, Karolin, Kay, Lewis E

“…The nucleosome core particle (NCP), comprised of histone proteins wrapped with ∼146 base pairs of DNA, provides both protection and controlled access to DNA so…”
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Redox Regulation of SH2-Domain-Containing Protein Tyrosine Phosphatases by Two Backdoor Cysteines by Chen, Cheng-Yu, Willard, Devina, Rudolph, Johannes

“…Protein tyrosine phosphatases (PTPs) are known to be regulated by phosphorylation, localization, and protein−protein interactions. More recently,…”
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Slow Inhibition and Conformation Selective Properties of Extracellular Signal-Regulated Kinase 1 and 2 Inhibitors by Rudolph, Johannes, Xiao, Yao, Pardi, Arthur, Ahn, Natalie G

“…The mitogen-activated protein (MAP) kinase pathway is a target for anticancer therapy, validated using inhibitors of B-Raf and MAP kinase kinase (MKK) 1 and 2…”
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Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol by Yadid, Itamar, Rudolph, Johannes, Hlouchova, Klara, Copley, Shelley D

“…Microbes in contaminated environments often evolve new metabolic pathways for detoxification or degradation of pollutants. In some cases, intermediates in…”
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Catalytic and Chemical Competence of Regulation of Cdc25 Phosphatase by Oxidation/Reduction by Sohn, Jungsan, Rudolph, Johannes

“…Cdc25 phosphatases belong to the family of protein tyrosine phosphatases (PTPs) that contain an active-site cysteine and form a phosphocysteine intermediate…”
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Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging by Mahadevan, Jyothi, Jha, Asmita, Rudolph, Johannes, Bowerman, Samuel, Narducci, Domenic, Hansen, Anders S., Luger, Karolin

“…PARP1 contributes to genome architecture and DNA damage repair through its dynamic association with chromatin. PARP1 and PARP2 (PARP1/2) recognize damaged DNA…”
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Structural Mechanism of Oxidative Regulation of the Phosphatase Cdc25B via an Intramolecular Disulfide Bond by Buhrman, Greg, Parker, Benjamin, Sohn, Jungsan, Rudolph, Johannes, Mattos, Carla

“…Cdc25B phosphatase, an important regulator of the cell cycle, forms an intramolecular disulfide bond in response to oxidation leading to reversible…”
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Superposition of structures in the interference zone between the southern Brasília belt and the central Ribeira belt in the region SW of Itajubá (MG), SE Brazil by Vinagre, Rodrigo, Trouw, Rudolph Allard Johannes, Kussama, Hugo, Peternel, Rodrigo, Mendes, Julio Cezar, Duffles, Patrícia

“…The study area is localized in the Socorro nappe, part of the southern Brasília belt, with a minor part in the Embu terrane, part of the central Ribeira belt…”
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The Energetic Network of Hotspot Residues between Cdc25B Phosphatase and its Protein Substrate by Sohn, Jungsan, Rudolph, Johannes

“…We have investigated the functional network of hotspot residues at the remote docking site of two cell cycle regulators, namely Cdc25B phosphatase and its…”
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Kinetic and Structural Studies of Specific Protein−Protein Interactions in Substrate Catalysis by Cdc25B Phosphatase by Sohn, Jungsan, Buhrman, Gregory, Rudolph, Johannes

“…Using a combination of steady-state and single-turnover kinetics, we probe substrate association, dissociation, and chemistry for the reaction of Cdc25B…”
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Cdc25 Phosphatases:  Structure, Specificity, and Mechanism by Rudolph, Johannes

“…Cdc25 phosphatases, as activators of the Cdk/cyclins, play critical roles in the regulation of the eukaryotic cell cycle. Because of their overexpression and…”
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PARP1 and HPF1 team up to flag down DNA-repair machinery by Rudolph, Johannes, Luger, Karolin

“…The enzymatic activity of PARP1—which adds chains of (poly-ADP)-ribose (PAR) to proteins—initiates DNA repair by leading to more-accessible chromatin and…”
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Age and geotectonic setting of Late Neoproterozoic juvenile mafic gneisses and associated paragneisses from the Ribeira belt (SE Brazil) based on geochemistry and Sm–Nd data — Implications on Gondwana assembly by da Silva Schmitt, Renata, Trouw, Rudolph Allard Johannes, Medeiros, Silvia Regina, Dantas, Elton Luiz

“…Mafic gneisses and associated paragneisses from the Cabo Frio Tectonic Domain in the southeastern part of the Ribeira Belt, along the coast of Rio de Janeiro…”
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U-Pb and Lu-Hf isotope systematics on detrital zircon from the southern São Francisco Craton's Neoproterozoic passive margin: Tectonic implications by Marimon, Rodrigo Schwantes, Johannes Trouw, Rudolph Allard, Dantas, Elton Luiz, Ribeiro, Andre

“…Isotopic Lu-Hf and U-Pb systematics can provide important insights into the tectono-metamorphic processes that occurred in the source regions of…”
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