Search Results - "Rudolph, E"

The role of innate immune genes in Alzheimer's disease by Griciuc, Ana, Tanzi, Rudolph E.

“…The aim of this study was to provide an update on the role of the innate immune system and neuroinflammation in the pathogenesis of Alzheimer's disease, with…”
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The neuroimmune axis of Alzheimer's disease by Jorfi, Mehdi, Maaser-Hecker, Anna, Tanzi, Rudolph E

“…Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with multifaceted neuropathological features, including β-amyloid plaques,…”
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The antimicrobial protection hypothesis of Alzheimer's disease by Moir, Robert D., Lathe, Richard, Tanzi, Rudolph E.

“…We explore here a novel model for amyloidogenesis in Alzheimer's disease (AD). This new perspective on AD amyloidosis seeks to provide a rational framework for…”
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Redlines and Greenspace: The Relationship between Historical Redlining and 2010 Greenspace across the United States by Nardone, Anthony, Rudolph, Kara E, Morello-Frosch, Rachel, Casey, Joan A

“…Redlining, a racist mortgage appraisal practice of the 1930s, established and exacerbated racial residential segregation boundaries in the United States…”
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The genetics of Alzheimer disease by Tanzi, Rudolph E

“…Family history is the second strongest risk factor for Alzheimer disease (AD) following advanced age. Twin and family studies indicate that genetic factors are…”
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Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses by Bertram, Lars, Tanzi, Rudolph E

“…Key Points Alzheimer's disease (AD) is a highly heritable disorder, the genetic underpinnings of which remain incompletely understood despite intense research…”
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Is Alzheimer’s Disease a Neurogenesis Disorder? by Choi, Se Hoon, Tanzi, Rudolph E.

“…The existence of adult hippocampal neurogenesis (AHN) in humans has been controversial. However, recent reports have detected AHN in aged adults and patients…”
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Alzheimer disease risk genes: 29 and counting by Bertram, Lars, Tanzi, Rudolph E.

“…The risk of Alzheimer disease is substantially influenced by genetic factors. A new genome-wide association study of more than 600,000 individuals identifies…”
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Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease by Zhang, Xueli, Tian, Yanli, Zhang, Can, Tian, Xiaoyu, Ross, Alana W., Moir, Robert D., Sun, Hongbin, Tanzie, Rudolph E., Moore, Anna, Ran, Chongzhao

“…Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring therapy of cancer and other diseases in preclinical studies; however,…”
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A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease by Park, Joseph, Wetzel, Isaac, Marriott, Ian, Dréau, Didier, D’Avanzo, Carla, Kim, Doo Yeon, Tanzi, Rudolph E., Cho, Hansang

“…Alzheimer’s disease (AD) is characterized by beta-amyloid accumulation, phosphorylated tau formation, hyperactivation of glial cells, and neuronal loss. The…”
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The Genetics of Alzheimer Disease: Back to the Future by Bertram, Lars, Lill, Christina M., Tanzi, Rudolph E.

“…Three decades of genetic research in Alzheimer disease (AD) have substantially broadened our understanding of the pathogenetic mechanisms leading to…”
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Adult neurogenesis in Alzheimer's disease by Choi, Se Hoon, Tanzi, Rudolph E.

“…Alzheimer's disease (AD) is the most common form of age‐related dementia, characterized by progressive memory loss and cognitive disturbances. The hippocampus,…”
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Genomic mechanisms in Alzheimer's disease by Bertram, Lars, Tanzi, Rudolph E.

“…Alzheimer's disease (AD) is the most common neurodegenerative disease and, owing to its increasing prevalence, represents one of the leading public health…”
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Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model by Choi, Se Hoon, Bylykbashi, Enjana, Chatila, Zena K, Lee, Star W, Pulli, Benjamin, Clemenson, Gregory D, Kim, Eunhee, Rompala, Alexander, Oram, Mary K, Asselin, Caroline, Aronson, Jenna, Zhang, Can, Miller, Sean J, Lesinski, Andrea, Chen, John W, Kim, Doo Yeon, van Praag, Henriette, Spiegelman, Bruce M, Gage, Fred H, Tanzi, Rudolph E

“…Adult hippocampal neurogenesis (AHN) is impaired before the onset of Alzheimer's disease (AD) pathology. We found that exercise provided cognitive benefit to…”
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TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease by Griciuc, Ana, Patel, Shaun, Federico, Anthony N., Choi, Se Hoon, Innes, Brendan J., Oram, Mary K., Cereghetti, Gea, McGinty, Danielle, Anselmo, Anthony, Sadreyev, Ruslan I., Hickman, Suzanne E., El Khoury, Joseph, Colonna, Marco, Tanzi, Rudolph E.

“…The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer’s disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We…”
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Therapeutics for Alzheimer's Disease Based on the Metal Hypothesis by Bush, Ashley I., Tanzi, Rudolph E.

“…Alzheimer's disease is the most common form of dementia in the elderly, and it is characterized by elevated brain iron levels and accumulation of copper and…”
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Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease by McAlpine, Cameron S., Park, Joseph, Griciuc, Ana, Kim, Eunhee, Choi, Se Hoon, Iwamoto, Yoshiko, Kiss, Máté G., Christie, Kathleen A., Vinegoni, Claudio, Poller, Wolfram C., Mindur, John E., Chan, Christopher T., He, Shun, Janssen, Henrike, Wong, Lai Ping, Downey, Jeffrey, Singh, Sumnima, Anzai, Atsushi, Kahles, Florian, Jorfi, Mehdi, Feruglio, Paolo Fumene, Sadreyev, Ruslan I., Weissleder, Ralph, Kleinstiver, Benjamin P., Nahrendorf, Matthias, Tanzi, Rudolph E., Swirski, Filip K.

“…Communication within the glial cell ecosystem is essential for neuronal and brain health 1 – 3 . The influence of glial cells on the accumulation and clearance…”
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Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease by Minter, Myles R., Zhang, Can, Leone, Vanessa, Ringus, Daina L., Zhang, Xiaoqiong, Oyler-Castrillo, Paul, Musch, Mark W., Liao, Fan, Ward, Joseph F., Holtzman, David M., Chang, Eugene B., Tanzi, Rudolph E., Sisodia, Sangram S.

“…Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features of Alzheimer’s disease (AD). In addition to astrocyte and microglial…”
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The genetic epidemiology of neurodegenerative disease by Bertram, Lars, Tanzi, Rudolph E

“…Gene defects play a major role in the pathogenesis of degenerative disorders of the nervous system. In fact, it has been the very knowledge gained from genetic…”
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Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease by Jorfi, Mehdi, D’Avanzo, Carla, Tanzi, Rudolph E., Kim, Doo Yeon, Irimia, Daniel

“…Neurospheroids are commonly used for in vitro disease modeling and drug screening. However, the heterogeneity in size of the neurospheroids mixtures available…”
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