Search Results - "Rudling, M"

Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism by Hu, X., Bonde, Y., Eggertsen, G., Rudling, M.

“…Objective Bile acid (BA) synthesis is regulated by negative feedback end‐product inhibition, initiated by farnesoid X receptors (FXRs) in liver and gut…”
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Globally distributed Myxococcota with photosynthesis gene clusters illuminate the origin and evolution of a potentially chimeric lifestyle by Li, Liuyang, Huang, Danyue, Hu, Yaoxun, Rudling, Nicola M., Canniffe, Daniel P., Wang, Fengping, Wang, Yinzhao

“…Photosynthesis is a fundamental biogeochemical process, thought to be restricted to a few bacterial and eukaryotic phyla. However, understanding the origin and…”
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Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19 by Gälman, C., Angelin, B., Rudling, M.

“…  Gälman C, Angelin B, Rudling M. (Karolinska Institutet at Karolinska University Hospital, Stockholm). Pronounced variation in bile acid synthesis in humans…”
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Overeating Saturated Fat Promotes Fatty Liver and Ceramides Compared With Polyunsaturated Fat: A Randomized Trial by Rosqvist, Fredrik, Kullberg, Joel, Ståhlman, Marcus, Cedernaes, Jonathan, Heurling, Kerstin, Johansson, Hans-Erik, Iggman, David, Wilking, Helena, Larsson, Anders, Eriksson, Olof, Johansson, Lars, Straniero, Sara, Rudling, Mats, Antoni, Gunnar, Lubberink, Mark, Orho-Melander, Marju, Borén, Jan, Ahlström, Håkan, Risérus, Ulf

“…Saturated fatty acid (SFA) vs polyunsaturated fatty acid (PUFA) may promote nonalcoholic fatty liver disease by yet unclear mechanisms. To investigate if…”
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Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man by LUNDÅSEN, T., GÄLMAN, C., ANGELIN, B, RUDLING, M.

“… Bile acids (BAs) traversing the enterohepatic circulation exert several important metabolic effects. Their hepatic synthesis, controlled by the enzyme…”
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Treatment with the natural FXR agonist chenodeoxycholic acid reduces clearance of plasma LDL whilst decreasing circulating PCSK9, lipoprotein(a) and apolipoprotein C‐III by Ghosh Laskar, M., Eriksson, M., Rudling, M., Angelin, B.

“…Background The natural farnesoid X receptor (FXR) agonist chenodeoxycholic acid (CDCA) suppresses hepatic cholesterol and bile acid synthesis and reduces…”
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Interstitial postprandial hyperlipidemia and remnant lipoproteins in type 2 diabetes mellitus by Härdfeldt, J., Björklund, P., Angelin, B., Rudling, M., Straniero, S.

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Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism by Al‐Khaifi, A., Straniero, S., Voronova, V., Chernikova, D., Sokolov, V., Kumar, C., Angelin, B., Rudling, M.

“…Background and Objectives Bile acids (BAs) traversing the enterohepatic circulation (EHC) influence important metabolic pathways. By determining individual…”
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Murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism by Straniero, S., Laskar, A., Savva, C., Härdfeldt, J., Angelin, B., Rudling, M.

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Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome by Johansson, H., Svensson, J. F., Almström, M., Van Hul, N., Rudling, M., Angelin, B., Nowak, G., Fischler, B., Ellis, E.

“…Background Fibroblast growth factor 19 (FGF19) is produced in the small intestine and is involved in suppression of hepatic bile acid (BA) synthesis. FGF19 is…”
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Posttranscriptional regulation of the LDLR by ACTH treatment – Importance of PCSK9 in liver while idol takes the scene in the adrenals by Laskar, M. Ghosh, Angelin, B, Rudling, M

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Acute caloric restriction counteracts hepatic bile acid and cholesterol deficiency in morbid obesity by Straniero, S., Rosqvist, F., Edholm, D., Ahlström, H., Kullberg, J., Sundbom, M., Risérus, U., Rudling, M.

“…Background Bile acid (BA) synthesis is regulated by BA signalling in the liver and by fibroblast growth factor 19 (FGF19), synthesized and released from the…”
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Randomised clinical trial: the ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation – a double‐blind study by Simrén, M., Bajor, A., Gillberg, P.‐G., Rudling, M., Abrahamsson, H.

“…Aliment Pharmacol Ther 2011; 34: 41–50 Summary Background  One half of patients with constipation are not satisfied with available therapies, hence there is a…”
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Mice abundant in muricholic bile acids show resistance to dietary induced steatosis, weight gain, and to impaired glucose metabolism by Bonde, Y, Eggertsen, G, Rudling, M

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Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism (vol 275, pg 27, 2014) by Hu, X, Bonde, Y, Eggertsen, G, Rudling, M

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Lipoprotein profiles in plasma and interstitial fluid analyzed with an automated gel-filtration system by Parini, P., Johansson, L., Bröijersén, A., Angelin, B., Rudling, M.

“…Background  High‐quality methods for lipoprotein characterization are warranted in studies on various metabolic diseases. Materials and methods  An automated…”
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Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice by Alberti, S., Schuster, G., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S., Gustafsson, J.-′„«.

“…The nuclear oxysterol-receptor paralogues LXR alpha and LXR beta share a high degree of amino acid identity and bind endogenous oxysterol ligands with similar…”
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Increased bile acid and cholesterol syntheses and PCSK9 in morbid obesity are rapidly normalized following acute caloric restriction by Straniero, S, Rosqvist, F, Edholm, D, Sundbom, M, Risérus, U, Rudling, M

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Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans by Lundberg, J., Höybye, C., Krusenstjerna‐Hafstrøm, T., Bina, H. A., Kharitonenkov, A., Angelin, B., Rudling, M.

“…Objective Findings from animal studies indicate that growth hormone (GH) may stimulate the production of the putative metabolic regulator fibroblast growth…”
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The role of the γ subunit in the photosystem of the lowest-energy phototrophs by Namoon, Dowrung, Rudling, Nicola M, Canniffe, Daniel P

“…Purple phototrophic bacteria use a 'photosystem' consisting of light harvesting complex 1 (LH1) surrounding the reaction centre (RC) that absorbs…”
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