Search Results - "Rudland, Philip S."

Joining S100 proteins and migration: for better or for worse, in sickness and in health by Gross, Stephane R, Sin, Connie Goh Then, Barraclough, Roger, Rudland, Philip S

“…The vast diversity of S100 proteins has demonstrated a multitude of biological correlations with cell growth, cell differentiation and cell survival in…”
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S100A4 Elevation Empowers Expression of Metastasis Effector Molecules in Human Breast Cancer by Ismail, Thamir M, Bennett, Daimark, Platt-Higgins, Angela M, Al-Medhity, Morteta, Barraclough, Roger, Rudland, Philip S

“…Many human glandular cancers metastasize along nerve tracts, but the mechanisms involved are generally poorly understood. The calcium-binding protein S100A4 is…”
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S100P Dissociates Myosin IIA Filaments and Focal Adhesion Sites to Reduce Cell Adhesion and Enhance Cell Migration by Du, Min, Wang, Guozheng, Ismail, Thamir M., Gross, Stephane, Fernig, David G., Barraclough, Roger, Rudland, Philip S.

“…S100 proteins promote cancer cell migration and metastasis. To investigate their roles in the process of migration we have constructed inducible systems for…”
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Targeted Destruction of S100A4 Inhibits Metastasis of Triple Negative Breast Cancer Cells by Ismail, Thamir M, Crick, Rachel G, Du, Min, Shivkumar, Uma, Carnell, Andrew, Barraclough, Roger, Wang, Guozheng, Cheng, Zhenxing, Yu, Weiping, Platt-Higgins, Angela, Nixon, Gemma, Rudland, Philip S

“…Most patients who die of cancer do so from its metastasis to other organs. The calcium-binding protein S100A4 can induce cell migration/invasion and metastasis…”
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The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell Migration and Metastasis by Ismail, Thamir M, Gross, Stephane R, Lancaster, Tara, Rudland, Philip S, Barraclough, Roger

“…S100P protein is a potent inducer of metastasis in a model system, and its presence in cancer cells of patients is strongly associated with their reduced…”
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Erythropoietin drives breast cancer progression by activation of its receptor EPOR by Chan, Ka Kui, Matchett, Kyle B, Coulter, Jonathan A, Yuen, Hiu-Fung, McCrudden, Cian M, Zhang, Shu-Dong, Irwin, Gareth W, Davidson, Matthew A, Rülicke, Thomas, Schober, Sophie, Hengst, Ludger, Jaekel, Heidelinde, Platt-Higgins, Angela, Rudland, Philip S, Mills, Ken I, Maxwell, Perry, El-Tanani, Mohamed, Lappin, Terence R

“…Breast cancer is a leading cause of cancer-related deaths. Anemia is common in breast cancer patients and can be treated with blood transfusions or with…”
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Asymmetric Mode of Ca2+-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling by Elliott, Paul R., Irvine, Andrew F., Jung, Hyun Suk, Tozawa, Kaeko, Pastok, Martyna W., Picone, Remigio, Badyal, Sandip K., Basran, Jaswir, Rudland, Philip S., Barraclough, Roger, Lian, Lu-Yun, Bagshaw, Clive R., Kriajevska, Marina, Barsukov, Igor L.

“…Filament assembly of nonmuscle myosin IIA (NMIIA) is selectively regulated by the small Ca2+-binding protein, S100A4, which causes enhanced cell migration and…”
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Increased plasma concentrations of anterior gradient 2 protein are positively associated with ovarian cancer by Edgell, Tracey A, Barraclough, Dong L, Rajic, Antonio, Dhulia, Janu, Lewis, Kate J, Armes, Jane E, Barraclough, Roger, Rudland, Philip S, Rice, Gregory E, Autelitano, Dominic J

“…Ovarian cancer is often asymptomatic and is diagnosed at an advanced stage with poor survival rates, thus there is an urgent need to develop biomarkers for…”
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Self-association of Calcium-binding Protein S100A4 and Metastasis by Ismail, Thamir M., Zhang, Shu, Fernig, David G., Gross, Stephane, Martin-Fernandez, Marisa L., See, Violaine, Tozawa, Kaeko, Tynan, Christopher J., Wang, Guozheng, Wilkinson, Mark C., Rudland, Philip S., Barraclough, Roger

“…Elevated levels of the calcium-binding protein S100A4 promote metastasis and in carcinoma cells are associated with reduced survival of cancer patients. S100A4…”
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Rat Muc4 (sialomucin complex) reduces binding of anti‐ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance by Price‐Schiavi, Shari A., Jepson, Scott, Li, Peter, Arango, Maria, Rudland, Philip S., Yee, Lisa, Carraway, Kermit L.

“…Muc4 (also called sialomucin complex), the rat homolog of human MUC4, is a heterodimeric glycoprotein complex that consists of a peripheral O‐glycosylated…”
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Significance of the Fanconi Anemia FANCD2 Protein in Sporadic and Metastatic Human Breast Cancer by Rudland, Philip S, Platt-Higgins, Angela M, Davies, Lowri M, de Silva Rudland, Suzete, Wilson, James B, Aladwani, Abdulaziz, Winstanley, John H.R, Barraclough, Dong L, Barraclough, Roger, West, Christopher R, Jones, Nigel J

“…FANCD2, a pivotal protein in the Fanconi anemia and BRCA pathway/network, is monoubiquitylated in the nucleus in response to DNA damage. This study examines…”
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Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts by Delehedde, Maryse, Lyon, Malcolm, Gallagher, John T, Rudland, Philip S, Fernig, David G

“…We examine the relationship between the chain length of heparin-derived oligosaccharides, fibroblast growth factor (FGF)-2 binding kinetics and the ability of…”
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High-level expression of cutaneous fatty acid-binding protein in prostatic carcinomas and its effect on tumorigenicity by ADAMSON, Janet, MORGAN, Elwin A, BEESLEY, Carol, YONGQIANG MEI, FOSTER, Christopher S, FUJII, Hiroshi, RUDLAND, Philip S, SMITH, Paul H, YOUQIANG KE

“…The expression of cutaneous fatty acid-binding protein (C-FABP) in prostate tissues was examined by immunohistochemistry. Among the 76 cases, all seven (100%)…”
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The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor by Zhu, Hongyan, Duchesne, Laurence, Rudland, Philip S, Fernig, David G

“…The fibroblast growth factor receptor (FGFR) interprets concentration gradients of FGF ligands and structural changes in the heparan sulfate (HS) co-receptor…”
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Osteopontin can act as an effector for a germline mutation of BRCA1 in malignant transformation of breast cancer‐related cells by El‐Tanani, Mohamed K., Yuen, Hiu‐Fung, Shi, Zhanzhong, Platt‐Higgins, Angela, Buckley, Niamh E., Mullan, Paul B., Harkin, Denis Paul, Johnston, Patrick G., Rudland, Philip S.

“…Breast cancer‐associated 1 (BRCA1) plays an important role in breast cancer initiation and progression through its functions in the cell cycle and DNA repair…”
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Immune checkpoint inhibitor treatment of brain metastasis associated with a less invasive growth pattern, higher T-cell infiltration and raised tumor ADC on diffusion weighted MRI by Zakaria, Rasheed, Jenkinson, Michael D., Radon, Mark, Das, Kumar, Poptani, Harish, Rathi, Nitika, Rudland, Philip S.

“…Background Brain metastases are the most common intracranial tumors with an increasing incidence. They are an important cause of morbidity and mortality in…”
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BRCA1 Suppresses Osteopontin-mediated Breast Cancer by El-Tanani, Mohamed K., Campbell, Frederick Charles, Crowe, Paul, Erwin, Pauline, Harkin, Denis Paul, Pharoah, Paul, Ponder, Bruce, Rudland, Philip S.

“…BRCA1 is a well described breast cancer susceptibility gene thought to be involved primarily in DNA repair. However, mutation within the BRCA1 transcriptional…”
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Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion by Du, Min, Wang, Guozheng, Barsukov, Igor L, Gross, Stephane R, Smith, Richard, Rudland, Philip S

“…Overexpression of S100P promotes breast cancer metastasis in animals and elevated levels in primary breast cancers are associated with poor patient outcomes…”
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T-Cell Densities in Brain Metastases Are Associated with Patient Survival Times and Diffusion Tensor MRI Changes by Zakaria, Rasheed, Platt-Higgins, Angela, Rathi, Nitika, Radon, Mark, Das, Sumit, Das, Kumar, Bhojak, Maneesh, Brodbelt, Andrew, Chavredakis, Emmanuel, Jenkinson, Michael D, Rudland, Philip S

“…Brain metastases are common and are usually detected by MRI. Diffusion tensor imaging (DTI) is a derivative MRI technique that can detect disruption of white…”
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Genomic profiling using the UltraSEEK panel identifies discordancy between paired primary and breast cancer brain metastases and an association with brain metastasis-free survival by Giannoudis, Athina, Sartori, Alexander, Eastoe, Lee, Zakaria, Rasheed, Charlton, Christopher, Hickson, Nicholas, Platt-Higgins, Angela, Rudland, Philip S., Irwin, Darryl, Jenkinson, Michael D., Palmieri, Carlo

“…Purpose Brain metastases (BM) are an increasing clinical problem. This study aimed to assess paired primary breast cancers (BC) and BM for aberrations within…”
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