Search Results - "Ruderman, Joan V"

Effects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryos by Chung, Eunah, Genco, Maria C, Megrelis, Laura, Ruderman, Joan V

“…Estrogen regulates numerous developmental and physiological processes. Most effects are mediated by estrogen receptors (ERs), which function as…”
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Aurora A, Mitotic Entry, and Spindle Bipolarity by Liu, Quentin, Ruderman, Joan V.

“…The kinase Aurora-A (Aur-A), which is enriched at centrosomes, is required for centrosome maturation and accurate chromosome segregation, and recent work…”
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Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit by Littlepage, Laurie E, Ruderman, Joan V

“…The mitotic kinase Aurora A (Aur-A) is required for formation of a bipolar mitotic spindle and accurate chromosome segregation. In somatic cells, Aur-A protein…”
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Aurora B Is Required for Mitotic Chromatin-Induced Phosphorylation of Op18/Stathmin by Gadea, Bedrick B., Ruderman, Joan V.

“…Oncoprotein 18/Stathmin (Op18) is a microtubule-destabilizing protein that is inhibited by phosphorylation in response to many types of signals. During…”
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G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A by Duckworth, Brian C, Weaver, Jennifer S, Ruderman, Joan V

“…Xenopus oocytes, which are arrested in G 2 of meiosis I, contain complexes of cyclin B–cdc2 (M phase-promoting factor) that are kept repressed by inhibitory…”
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Identification of Phosphorylated Residues That Affect the Activity of the Mitotic Kinase Aurora-A by Littlepage, Laurie E., Wu, Hua, Andresson, Thorkell, Deanehan, Julia K., Amundadottir, Laufey T., Ruderman, Joan V.

“…The activity of the kinase Aurora-A (Aur-A) peaks during mitosis and depends on phosphorylation by one or more unknown kinases. Mitotic phosphorylation sites…”
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Requirements for the destruction of human Aurora-A by Crane, Richard, Kloepfer, Angela, Ruderman, Joan V

“…The mitotic kinase Aurora A (Aur-A) is overexpressed in a high proportion of human tumors, often in the absence of gene amplification. In somatic cells, Aur-A…”
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Aurora A, Meiosis and Mitosis by Crane, Richard, Gadea, Bedrick, Littlepage, Laurie, Wu, Hua, Ruderman, Joan V

“…The Aurora family kinases are pivotal to the successful execution of cell division. Together they ensure the formation of a bipolar mitotic spindle, accurate…”
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Identification of XPR-1, a Progesterone Receptor Required for Xenopus Oocyte Activation by Tian, J, Kim, S, Heilig, E, Ruderman, J V

“…Quiescent full-grown Xenopus oocytes remain arrested at the G2/M border of meiosis I until exposed to progesterone, their natural mitogen. Progesterone…”
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Phosphorylation of CPE binding factor by Eg2 regulates translation of c- mos mRNA by Richter, Joel D, Mendez, Raul, Hake, Laura E, Andresson, Thorkell, Littlepage, Laurie E, Ruderman, Joan V

“…Full-grown Xenopus oocytes arrest at the G2/M border of meiosis I. Progesterone breaks this arrest, leading to the resumption of the meiotic cell cycles and…”
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Dominant-Negative Cyclin-Selective Ubiquitin Carrier Protein E2-C/UbcH10 Blocks Cells in Metaphase by Townsley, Fiona M., Aristarkhov, Alexander, Beck, Sharon, Hershko, Avram, Ruderman, Joan V.

“…Destruction of mitotic cyclins by ubiquitin-dependent proteolysis is required for cells to complete mitosis and enter interphase of the next cell cycle. In…”
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Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts by Gadea, Bedrick B, Ruderman, Joan V

“…The Aurora family kinases contribute to accurate progression through several mitotic events. ZM447439 ("ZM"), the first Aurora family kinase inhibitor to be…”
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Cdc20 Associates with the Kinase Aurora2/Aik by Farruggio, Dawn C., Townsley, Fiona M., Ruderman, Joan V.

“…Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent protcolysis of cell…”
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A novel cyclin encoded by a bcl1 -linked candidate oncogene by Motokura, Toru, Bloom, Theodora, Kim, Hyung Goo, Jüppner, Harald, Ruderman, Joan V, Kronenberg, Henry M, Arnold, Andrew

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Cleavage of Cyclin A at R70/R71 by the Bacterial Protease OmpT by Yam, Cain H., Siu, Wai Yi, Kaganovich, Daniel, Ruderman, Joan V., Randy Y. C. Poon

“…Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro-coupled transcription/translation system…”
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Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests by Stanford, Jennifer S, Ruderman, Joan V

“…Entry into mitosis is catalyzed by cdc2 kinase. Previous work identified the cdc2-activating phosphatase cdc25C and the cdc2-inhibitory kinase wee1 as targets…”
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The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway by Andrésson, Thorkell, Ruderman, Joan V.

“…Quiescent Xenopus oocytes are activated by progesterone, which binds to an unidentified surface‐associated receptor. Progesterone activates a poorly understood…”
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The role of cyclin synthesis, modification and destruction in the control of cell division by MINSHULL, J, PINES, J, GOLSTEYN, R, STANDART, N, MACKIE, S, COLMAN, A, BLOW, J, RUDERMAN, J. V, WU, M, HUNT, T

“…This paper reviews our current knowledge of the cyclins based on observations of the oocytes and eggs of sea urchins, clams and frogs. Cyclins are proteins…”
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Using Xenopus oocyte extracts to study signal transduction by Crane, Richard F, Ruderman, Joan V

“…Xenopus oocytes are naturally arrested at G2/M in prophase I of meiosis. Stimulation with progesterone initiates a nontranscriptional signaling pathway that…”
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CK2β, which inhibits Mos function, binds to a discrete domain in the N-terminus of Mos by Lieberman, Soyan L, Ruderman, Joan V

“…Progesterone stimulates G2-arrested Xenopus oocytes to synthesize Mos, a MAPK kinase kinase required for the coordinated activation of cdc2 and the G2/Meiosis…”
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