Search Results - "Ruderman, J V"

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis by Sudakin, V, Ganoth, D, Dahan, A, Heller, H, Hershko, J, Luca, F C, Ruderman, J V, Hershko, A

“…The ubiquitin-mediated degradation of mitotic cyclins is required for cells to exit from mitosis. Previous work with cell-free systems has revealed four…”
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Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells by SHIBUYA, E. K, RUDERMAN, J. V

“…Mitogen-activated protein kinases (MAPKs) are rapidly and transiently activated when both quiescent Go-arrested cells and G2-arrested oocytes are stimulated to…”
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Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2 by HERSHKO, A, GANOTH, D, SUDAKIN, V, DAHAN, A, COHEN, L. H, LUCA, F. C, RUDERMAN, J. V, EYTAN, E

“…Cyclin B, a positive regulatory subunit of the cdc2 protein kinase complex, is synthesized across the cell cycle and then rapidly degraded at the end of…”
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The Requirements for Protein Synthesis and Degradation, and the Control of Destruction of Cyclins A and B in the Meiotic and Mitotic Cell Cycles of the Clam Embryo by Hunt, Tim, Luca, Francis C., Ruderman, Joan V.

“…Fertilization of clam oocytes initiates a series of cell divisions, of which the first three-meiosis I, meiosis II, and the first mitotic division-are highly…”
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Reversible Phosphorylation Controls the Activity of Cyclosome-Associated Cyclin-Ubiquitin Ligase by Lahav-Baratz, Shirly, Sudakin, Valery, Ruderman, Joan V., Hershko, Avram

“…Cyclin B/cdc2 is responsible both for driving cells into mitosis and for activating the ubiquitin-dependent degradation of mitotic cyclins near the end of…”
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E2-C, a Cyclin-Selective Ubiquitin Carrier Protein Required for the Destruction of Mitotic Cyclins by Aristarkhov, Alexander, Eytan, Esther, Moghe, Ameena, Admon, Arie, Hershko, Avram, Ruderman, Joan V.

“…Ubiquitin-dependent proteolysis of the mitotic cyclins A and B is required for the completion of mitosis and entry into the next cell cycle. This process is…”
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EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction by ARVAND, A, BASTIANS, H, WELFORD, S. M, THOMPSON, A. D, RUDERMAN, J. V, DENNY, C. T

“…The EWS/FLI1 fusion gene found in Ewing's sarcoma and primitive neuroectodermal tumor, is able to transform certain cell lines by acting as an aberrant…”
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Control of Programmed Cyclin Destruction in a Cell-Free System by Luca, Francis C., Ruderman, Joan V.

“…To ask what controls the periodic accumulation and destruction of the mitotic cyclins across the cell cycle, we have developed a cell-free system from clam…”
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Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit by Littlepage, Laurie E, Ruderman, Joan V

“…The mitotic kinase Aurora A (Aur-A) is required for formation of a bipolar mitotic spindle and accurate chromosome segregation. In somatic cells, Aur-A protein…”
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The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes by Swenson, K I, Farrell, K M, Ruderman, J V

“…Fertilized clam embryos synthesize several new cell-cycle-related proteins. The cloned cDNA and derived amino acid sequences of one of these, cyclin A, are…”
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The Role of Cyclin B in Meiosis I by Westendorf, Joanne M., Swenson, Katherine I., Ruderman, Joan V.

“…In clams, fertilization is followed by the prominent synthesis of two cyclins, A and B. During the mitotic cell cycles, the two cyclins are accumulated and…”
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Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest by Shibuya, E.K., Boulton, T.G., Cobb, M.H., Ruderman, J.V.

“…Clam oocytes are arrested naturally at the G2/M border in meiosis and contain an inactive 42 kDa ERK/MAP kinase, p42MAPK. Following fertilization, p42MAPK is…”
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Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes by Shibuya, E K, Polverino, A J, Chang, E, Wigler, M, Ruderman, J V

“…Quiescent, full-grown Xenopus oocytes, which are arrested at the G2/M border of meiosis, contain an inactive 42-kDa mitogen-activated protein kinase (p42MAPK)…”
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The role of cyclin synthesis, modification and destruction in the control of cell division by MINSHULL, J, PINES, J, GOLSTEYN, R, STANDART, N, MACKIE, S, COLMAN, A, BLOW, J, RUDERMAN, J. V, WU, M, HUNT, T

“…This paper reviews our current knowledge of the cyclins based on observations of the oocytes and eggs of sea urchins, clams and frogs. Cyclins are proteins…”
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Identification of Phosphorylated Residues That Affect the Activity of the Mitotic Kinase Aurora-A by Littlepage, Laurie E., Wu, Hua, Andresson, Thorkell, Deanehan, Julia K., Amundadottir, Laufey T., Ruderman, Joan V.

“…The activity of the kinase Aurora-A (Aur-A) peaks during mitosis and depends on phosphorylation by one or more unknown kinases. Mitotic phosphorylation sites…”
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Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25 by Zheng, X F, Ruderman, J V

“…Cyclin B-cdc2 complexes are kept inactive by inhibitory phosphorylations on Thr-14 and Tyr-15 of cdc2 until they are dephosphorylated at the end of G2 by the…”
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Identification of XPR-1, a Progesterone Receptor Required for Xenopus Oocyte Activation by Tian, J, Kim, S, Heilig, E, Ruderman, J V

“…Quiescent full-grown Xenopus oocytes remain arrested at the G2/M border of meiosis I until exposed to progesterone, their natural mitogen. Progesterone…”
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Phosphorylation of CPE binding factor by Eg2 regulates translation of c- mos mRNA by Richter, Joel D, Mendez, Raul, Hake, Laura E, Andresson, Thorkell, Littlepage, Laurie E, Ruderman, Joan V

“…Full-grown Xenopus oocytes arrest at the G2/M border of meiosis I. Progesterone breaks this arrest, leading to the resumption of the meiotic cell cycles and…”
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The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway by Andrésson, Thorkell, Ruderman, Joan V.

“…Quiescent Xenopus oocytes are activated by progesterone, which binds to an unidentified surface‐associated receptor. Progesterone activates a poorly understood…”
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A novel cyclin encoded by a bcl1-linked candidate oncogene by Motokura, T, Bloom, T, Kim, H G, Jüppner, H, Ruderman, J V, Kronenberg, H M, Arnold, A

“…We have previously identified a candidate oncogene (PRAD1 or D11S287E) on chromosome 11q13 which is clonally rearranged with the parathyroid hormone locus in a…”
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