Search Results - "Rudebush, Tara"

Extracellular Vesicles Regulate Sympatho-Excitation by Nrf2 in Heart Failure by Tian, Changhai, Gao, Lie, Rudebush, Tara L., Yu, Li, Zucker, Irving H.

“…Chronic heart failure (CHF) is associated with redox imbalance. Downregulation of Nrf2 (nuclear factor [erythroid-derived 2]-like 2) plays important roles in…”
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Nrf2-Keap1 in Cardiovascular Disease: Which Is the Cart and Which the Horse? by Dhyani, Neha, Tian, Changhai, Gao, Lie, Rudebush, Tara L, Zucker, Irving H

“…High levels of oxidant stress in the form of reactive oxidant species are prevalent in the circulation and tissues in various types of cardiovascular disease…”
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Curcumin improves exercise performance of mice with coronary artery ligation-induced HFrEF: Nrf2 and antioxidant mechanisms in skeletal muscle by Wafi, Ahmed M, Hong, Juan, Rudebush, Tara L, Yu, Li, Hackfort, Bryan, Wang, Hanjun, Schultz, Harold D, Zucker, Irving H, Gao, Lie

“…A hallmark of chronic heart failure (HF) with low ejection fraction (HFrEF) is exercise intolerance. We hypothesized that reduced expression of nuclear factor…”
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Identification of Cardiac Expression Pattern of Transient Receptor Potential Vanilloid Type 1 (TRPV1) Receptor using a Transgenic Reporter Mouse Model by Hong, Juan, Lisco, Amanda M., Rudebush, Tara L., Yu, Li, Gao, Lie, Kitzerow, Oliver, Zucker, Irving H., Wang, Han-Jun

“…•The TRPV1cre-tdTomato reporter mouse model was sensitive to detect the TRPV1 cells.•The reporter mouse model suggested that TRPV1 channels were not expressed…”
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Functional, proteomic and bioinformatic analyses of Nrf2‐ and Keap1‐ null skeletal muscle by Gao, Lie, Kumar, Vikas, Vellichirammal, Neetha Nanoth, Park, Song‐Young, Rudebush, Tara L., Yu, Li, Son, Won‐Mok, Pekas, Elizabeth J., Wafi, Ahmed M., Hong, Juan, Xiao, Peng, Guda, Chittibabu, Wang, Han‐Jun, Schultz, Harold D., Zucker, Irving H.

“…Key points Nrf2 is a master regulator of endogenous cellular defences, governing the expression of more than 200 cytoprotective proteins, including a panel of…”
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Quantitative Proteomics Identifies Novel Nrf2-Mediated Adaptative Signaling Pathways in Skeletal Muscle Following Exercise Training by Bhat, Anjali, Abu, Rafay, Jagadesan, Sankarasubramanian, Vellichirammal, Neetha Nanoth, Pendyala, Ved Vasishtha, Yu, Li, Rudebush, Tara L, Guda, Chittibabu, Zucker, Irving H, Kumar, Vikas, Gao, Lie

“…Exercise training (ExT) improves skeletal muscle health via multiple adaptative pathways. Nrf2 is a principal antioxidant transcription factor responsible for…”
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Prostanoid Receptor Antagonist Effects on Intraocular Pressure, Supported by Ocular Biodisposition Experiments by Woodward, David F, Wenthur, Stacey L, Rudebush, Tara L, Fan, Shan, Toris, Carol B

“…Since all prostanoid receptors affect intraocular pressure (IOP) and endogenous prostanoids are found in ocular tissues, the pressor effects of prostanoid…”
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ARTERIAL BAROREFLEX FUNCTION IS IMPAIRED DURING THE RECOVERY FROM ACUTE LUNG INJURY IN A BLEOMYCIN-INDUCED RAT LUNG INJURY MODEL by Wang, Hanjun, Rudebush, Tara, Zucker, Irving

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The Role of Skeletal Muscle Nrf2 on Cardiac Function in Mice by Wang, Lucas, Dhyani, Neha, Rudebush, Tara, Gao, Lie, Zucker, Irving

“…Abstract only Introduction: Excessive oxidant stress has been shown to damage cardiac tissue and result in impaired cardiac function. Animals with chronic…”
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Endothelial Nrf2 modulates blood pressure and vasoconstrictor responses in conscious mice by Dhyani, Neha, Rudebush, Tara, Gao, Li, Zucker, Irving

“…Abstract only Introduction: Excessive oxidant stress has been shown to mediate a variety of cardiovascular pathological conditions, including hypertension. The…”
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Cardiac-derived extracellular vesicles contribute to sympathetic excitation by disrupting the central redox homeostasis in heart failure by Tian, Changhai, Gao, Lie, Edwin, Maria Rose, Rudebush, Tara, Yu, Li, Zucker, Irving

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Extracellular Vesicles Regulate Sympatho-Excitation by Nrf2 in Heart Failure by Tian, Changhai, Gao, Lie, Rudebush, Tara L., Yu, Li, Zucker, Irving H.

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Upregulating Nrf2 in the RVLM ameliorates sympatho-excitation in mice with chronic heart failure by Ma, Anyun, Hong, Juan, Shanks, Julia, Rudebush, Tara, Yu, Li, Hackfort, Bryan T, Wang, Hanjun, Zucker, Irving H, Gao, Lie

“…Nuclear factor E2-related factor 2 (Nrf2) is a key transcription factor that maintains redox homeostasis by governing a broad array of antioxidant genes in…”
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Skeletal muscle-derived extracellular vesicles contribute to post-exercise hypotension by BHAT, ANJALI, Sharma, Kanika, Bruening, Will, Lofgren, Brenden, Yu, Li, Rudebush, Tara, Kumar, Vikas, Zucker, Irving, Gao, Lie

“…Abstract only Post-exercise hypotension (PEH) is an immediate reduction in blood pressure (BP) after a single bout of exercise that forms the long-term…”
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Overexpression of Central ACE2 Attenuates the Pressor Response to Chronic Central Infusion of Angiotensin II: A Potential Role for Nrf2 by Ma, Anyun, Gao, Lie, Wafi, Ahmed M., Yu, Li, Rudebush, Tara, Zhou, Wenxian, Zucker, Irving H.

“…We investigated the mechanism by which ACE2 overexpression alters neurohumoral outflow and central oxidative stress is still unclear. Nuclear factor…”
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Overexpression of Central ACE2 (Angiotensin-Converting Enzyme 2) Attenuates the Pressor Response to Chronic Central Infusion of Ang II (Angiotensin II): A Potential Role for Nrf2 (Nuclear Factor [Erythroid-Derived 2]-Like 2) by Ma, Anyun, Gao, Lie, Wafi, Ahmed M., Yu, Li, Rudebush, Tara, Zhou, Wenxian, Zucker, Irving H.

“…We investigated the mechanism by which ACE2 (angiotensin-converting enzyme 2) overexpression alters neurohumoral outflow and central oxidative stress. Nrf2…”
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Endothelial Nrf2-KO attenuates endothelial function and skeletal muscle antioxidant capacity by Pekas, Elizabeth, Anderson, Cody, Allen, Michael, Jallen, Kollyn, Jin, Dong gun, Gao, Lie, Dhyani, Neha, Rudebush, Tara, Park, Sangseo, Zucker, Irving, Park, Song-Young

“…Abstract only Introduction: Endothelial dysfunction is considered a key contributor to vascular pathologies. It is well-accepted that excessive reactive oxygen…”
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Proteomic and Functional Analyses of Keap1‐Nrf2 Pathway in Skeletal Muscle by Gao, Lie, Kumar, Vikas, Hackfort, Bryan, Rudebush, Tara L, Yu, Li, Schultz, Harold D, Zucker, Irving H

“…The Nrf2/Keap1 pathway plays a critical role in maintaining redox homeostasis. To determine its significance in skeletal muscle, we created two novel…”
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Nrf2 Activation by Curcumin Improves Exercise Performance of Mice with Chronic Heart Failure by Gao, Lie, Rudebush, Tara L, Wafi, Ahmed M, Zucker, Irving H, Schultz, Harold D

“…Abstract only…”
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Label Free Quantitative Proteomic using Progenesis QI proteomics Reveals Novel Mechanism of Redox Regulation in Skeletal Muscles by Kumar, Vikas, Gao, Lie, Rudebush, Tara L., Yu, Li, Schultz, Harold D., Zucker, Irving

“…There is a high production of reactive oxygen species in skeletal muscle during stress such as exercise. The Nrf2/Keap1 pathway plays a critical role in…”
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