Search Results - "Ruddock, M. W."

Nicotinamide-inhibited vasoconstriction: lack of dependence on agonist signalling pathways by Burns, Deirdre M, Ruddock, Mark W, Walker, Mark D, Allen, James M, Kennovin, Gordon D, Hirst, David G

“…Previously, we have shown that nicotinamide inhibits both high [K +]- and phenylephrine-induced constrictions in a dose-dependent manner in rat tail arteries…”
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The effect of nicotinamide on spontaneous and induced activity in smooth and skeletal muscle by Ruddock, Mark W, Burns, Deirdre M, Murphy, Lynne E, O'Rourke, Martin G, Hirst, David G

“…Background and purpose: Nicotinamide (NA) is currently undergoing clinical trials as a tumour radiosensitizer. The dose that can be administered is currently…”
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Contractile properties of human renal cell carcinoma recruited arteries and their response to nicotinamide by Ruddock, Mark W, Burns, Deirdre M, McKeown, Stephanie R, Murphy, Lynn, Walsh, Ian K, Keane, Patrick F, Hirst, David G

“…Background and purpose: The manipulation of tumour blood supply and thus oxygenation is a potentially important strategy for improving the treatment of solid…”
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Saturated Fatty Acids Inhibit Hepatic Insulin Action by Modulating Insulin Receptor Expression and Post-receptor Signalling by Ruddock, Mark W, Stein, Andrew, Landaker, Edwin, Park, Jun, Cooksey, Robert C, McClain, Donald, Patti, Mary-Elizabeth

“…Free fatty acids (FFAs) are proposed to play a pathogenic role in both peripheral and hepatic insulin resistance. We have examined the effect of saturated FFA…”
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Biomarkers That Differentiate Benign Prostatic Hyperplasia from Prostate Cancer: A Literature Review by McNally, Christopher J, Ruddock, Mark W, Moore, Tara, McKenna, Declan J

“…Prediction of prostate cancer in primary care is typically based upon serum total prostate-specific antigen (tPSA) and digital rectal examination results…”
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Thrombomodulin Expression in Bladder Cancer Tissue and Its Association with Prognosis and Patient Survival by Watt, Joanne, Maguire, Daniel G, Reid, Cherith N, Lamont, John V, Fitzgerald, Stephen P, Ruddock, Mark W

“…Decreased expression of thrombomodulin (TM) in bladder cancer tissue has been shown to be associated with cell proliferation, increased malignancy and a poor…”
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Nicotinamide relaxes vascular smooth muscle by inhibiting myosin light chain kinase-dependent signaling pathways: implications for anticancer efficacy by Ruddock, Mark W, Hirst, David G

“…Nicotinamide has been shown to be an effective tumor oxygenator in preclinical studies and is part of a promising clinical protocol for the treatment of cancer…”
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Pentoxifylline inhibits agonist-induced vasoconstriction in vascular smooth muscle and spontaneous peristalsis in isolated ileum by Ruddock, Mark W, Hirst, David G

“…Pentoxifylline (PTX) is currently used therapeutically as a tumor oxygenator where it been shown to increase tumor blood flow and potentiate ionizing radiation…”
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The effect of the vasodilator nicotinamide on cyclic nucleotide pathways in vascular smooth muscle by Burns, D M, Ruddock, M W, Brown, J C, Kennovin, G D, Dykes, E L, Flitney, F W, Hirst, D G

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Royal academy of medicine in Ireland section of biomedical sciences: Proceedings of winter meeting held in Trinity College Dublin, 1996 by Sharma, S., Sharma, S. C., Byrne, P. D., Lyons, J. B., Boylan, J. F., McShane, A. J., Galligan, E. S., Sweetman, S. F., Clements, B. A., Lowe, A. S., McCormack, K. J. M., Walsh, D. M., Baxter, G. D., Allen, J. M., Kelleher, S., Keenan, A. K., Burns, D. M., Brown, J. C. W., Ruddock, M. W., Kennovin, G. D., Dykes, E. L., Flitney, F. W., Hirst, D. G., Winter, D. C., Cuffe, J., O’Sullivan, G. C., Harvey, B. J., Thompson, G. H., Murray, J. M., Brehony, F., Kelly, J. P., Leonard, B. E., Cotton, K. D., Hollywood, M. A., McHale, N. G., Thornbury, K. D., Stapleton, M. T., Allshire, A. P., Freeburn, J. C., Wallace, J. M. W., Sinnamon, D., Craig, B., Strain, J. J., Gilmore, W. S., Lyons, J. D. M, Murray, J., Trinick, T., Fee, J. P. H., Hennessy, L., Watson, A. W. S., Halley, W. L., Weir, M. A., Friery, O. P., Hejmadi, M. V., McIntyre, I. A., McALeer, J. J. A., Patterson, L. H., McKeown, S. R., Leckey, J. L., Nevin, G. B., Soppitt, D. S., Harkin, A. J., Wrynn, A. S., Earley, B., Dineen, T. M., Powell, R., Houghton, J. A., Cantillon, D., McDaid, J., O’Halloran, K. D., Bradford, A., Curran, A. K., Harmon, D., Sweeney, M., McLoughlin, P., O’Leary, D., O’Connor, J. J., Broderick, A. M., Keon, N., Martin, F.

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