Search Results - "Ruddle, Nancy H."

High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation by Ruddle, Nancy H

“…High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function of the immune system, by providing communication between the body…”
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The durability of immunity against reinfection by SARS-CoV-2: a comparative evolutionary study by Townsend, Jeffrey P, Hassler, Hayley B, Wang, Zheng, Miura, Sayaka, Singh, Jaiveer, Kumar, Sudhir, Ruddle, Nancy H, Galvani, Alison P, Dornburg, Alex

“…Among the most consequential unknowns of the devastating COVID-19 pandemic are the durability of immunity and time to likely reinfection. There are limited…”
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Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response by Ruddle, Nancy H, Akirav, Eitan M

“…Secondary lymphoid organs (SLOs) include lymph nodes, spleen, Peyer's patches, and mucosal tissues such as the nasal-associated lymphoid tissue, adenoids, and…”
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A Dendritic-Cell-Stromal Axis Maintains Immune Responses in Lymph Nodes by Kumar, Varsha, Dasoveanu, Dragos C., Chyou, Susan, Tzeng, Te-Chen, Rozo, Cristina, Liang, Yong, Stohl, William, Fu, Yang-Xin, Ruddle, Nancy H., Lu, Theresa T.

“…Within secondary lymphoid tissues, stromal reticular cells support lymphocyte function, and targeting reticular cells is a potential strategy for controlling…”
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Synchrony of High Endothelial Venules and Lymphatic Vessels Revealed by Immunization by Liao, Shan, Ruddle, Nancy H

“…The mature phenotype of peripheral lymph node (LN) high endothelial venules (HEVs), defined as MAdCAM-1(low) PNAd(high) LTbetaR(high) HEC-6ST(high), is…”
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Impaired lymphatic contraction associated with immunosuppression by Liao, Shan, Cheng, Gang, Conner, David A., Huang, Yuhui, Kucherlapati, Raju S., Munn, Lance L., Ruddle, Nancy H., Jain, Rakesh K., Fukumura, Dai, Padera, Timothy P.

“…To trigger an effective immune response, antigen and antigen-presenting cells travel to the lymph nodes via collecting lymphatic vessels. However, our…”
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Identification of a new stromal cell type involved in the regulation of inflamed B cell follicles by Mionnet, Cyrille, Mondor, Isabelle, Jorquera, Audrey, Loosveld, Marie, Maurizio, Julien, Arcangeli, Marie-Laure, Ruddle, Nancy H, Nowak, Jonathan, Aurrand-Lions, Michel, Luche, Hervé, Bajénoff, Marc

“…Lymph node (LN) stromal cells provide survival signals and adhesive substrata to lymphocytes. During an immune response, B cell follicles enlarge, questioning…”
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Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma by Stranford, Sharon, Ruddle, Nancy H

“…In this communication, the contribution of stromal, or non-hematopoietic, cells to the structure and function of lymph nodes (LNs), as canonical secondary…”
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Prevention of Diabetes by FTY720-Mediated Stabilization of Peri-Islet Tertiary Lymphoid Organs by PENARANDA, Cristina, QIZHI TANG, RUDDLE, Nancy H, BLUESTONE, Jeffrey A

“…The nonobese diabetic (NOD) mouse is a well-established mouse model of spontaneous type 1 diabetes, which is characterized by an autoimmune destruction of the…”
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Lymphatic vessels and tertiary lymphoid organs by Ruddle, Nancy H

“…Tertiary lymphoid organs (TLOs) are accumulations of lymphoid cells in chronic inflammation that resemble LNs in their cellular content and organization, high…”
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The role of AIRE in human autoimmune disease by Herold, Kevan C, Akirav, Eitan M, Ruddle, Nancy H

“…This Review describes the process of positive and negative selection of developing T cells in the thymus and the role of the autoimmune regulator (AIRE) in the…”
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Posttransplant Tertiary Lymphoid Organs by Ruddle, Nancy H

“…Tertiary lymphoid organs (TLOs), also known as tertiary or ectopic lymphoid structures or tissues, are accumulations of lymphoid cells in sites other than…”
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Mechanistic basis of post-treatment control of SIV after anti-α4β7 antibody therapy by Wells, Chad R., Cao, Youfang, Durham, David P., Byrareddy, Siddappa N., Ansari, Aftab A., Ruddle, Nancy H., Townsend, Jeffrey P., Galvani, Alison P., Perelson, Alan S.

“…Treating macaques with an anti-α4β7 antibody under the umbrella of combination antiretroviral therapy (cART) during early SIV infection can lead to viral…”
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A Humanized Mouse Model of Autoimmune Insulitis by MILAM, Ashley A. Viehmann, MAHER, Stephen E, GIBSON, Joanna A, LEBASTCHI, Jasmin, LI WEN, RUDDLE, Nancy H, HEROLD, Kevan C, BOTHWELL, Alfred L. M

“…Many mechanisms of and treatments for type 1 diabetes studied in the NOD mouse model have not been replicated in human disease models. Thus, the field of…”
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Lymphotoxin and TNF: How it all began—A tribute to the travelers by Ruddle, Nancy H

“…Abstract The journey from the discoveries of lymphotoxin (LT) and tumor necrosis factor (TNF) to the present day age of cytokine inhibitors as therapeutics has…”
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Pathogenic Myelin Oligodendrocyte Glycoprotein Antibodies Recognize Glycosylated Epitopes and Perturb Oligodendrocyte Physiology by Marta, Cecilia B., Oliver, Alfred R., Sweet, Rebecca A., Pfeiffer, Steven E., Ruddle, Nancy H., Cresswell, Peter

“…Antibodies to myelin components are routinely detected in multiple sclerosis patients. However, their presence in some control subjects has made it difficult…”
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Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice by Oliver, Alfred R, Lyon, Geoffrey M, Ruddle, Nancy H

“…C57BL/6 mice immunized with the extracellular Ig-like domain of rat myelin oligodendrocyte glycoprotein (MOG) developed experimental autoimmune…”
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Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis by Camell, Christina D., Günther, Patrick, Lee, Aileen, Goldberg, Emily L., Spadaro, Olga, Youm, Yun-Hee, Bartke, Andrzej, Hubbard, Gene B., Ikeno, Yuji, Ruddle, Nancy H., Schultze, Joachim, Dixit, Vishwa Deep

“…During aging, visceral adiposity is often associated with alterations in adipose tissue (AT) leukocytes, inflammation, and metabolic dysfunction. However, the…”
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Regulation, Maintenance, and Remodeling of High Endothelial Venules in Homeostasis, Inflammation, and Cancer by Ruddle, Nancy H

“…High endothelial venules (HEVs), high walled cuboidal blood vessels, through their expression of adhesion molecules and chemokines, allow the entrance of…”
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Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis by Juedes, Amy E, Ruddle, Nancy H

“…During experimental autoimmune encephalomyelitis (EAE), autoreactive Th1 T cells invade the CNS. Before performing their effector functions in the target…”
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