Search Results - "Rudd, John A."

Predicting drug adverse effects using a new Gastro-Intestinal Pacemaker Activity Drug Database (GIPADD) by Liu, Julia Yuen Hang, Rudd, John A.

“…Electrical data could be a new source of big-data for training artificial intelligence (AI) for drug discovery. A Gastro-Intestinal Pacemaker Activity Drug…”
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COVID‐19, nausea, and vomiting by Andrews, Paul L R, Cai, Weigang, Rudd, John A, Sanger, Gareth J

“…Exclusion of nausea (N) and vomiting (V) from detailed consideration as symptoms of COVID‐19 is surprising as N can be an early presenting symptom. We examined…”
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Mechanisms of Chemotherapy-Induced Neurotoxicity by Was, Halina, Borkowska, Agata, Bagues, Ana, Tu, Longlong, Liu, Julia Y H, Lu, Zengbing, Rudd, John A, Nurgali, Kulmira, Abalo, Raquel

“…Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been extensively used in the clinic as the main cancer treatment…”
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Editorial: Cancer therapy: The challenge of handling a double-edged sword by Nurgali, Kulmira, Rudd, John A., Was, Halina, Abalo, Raquel

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GLP-1 receptors are involved in the GLP-1 (7–36) amide-induced modulation of glucose homoeostasis, emesis and feeding in Suncus murinus (house musk shrew) by Lu, Zengbing, Chan, Sze Wa, Tu, Longlong, Ngan, Man Piu, Rudd, John A.

“…GLP-1 receptor agonists are used for the treatment of type 2 diabetes but they may reduce appetite and cause nausea and emesis. We investigated if GLP-1 (7–36)…”
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Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells by Kan, Winnie Lai Ting, Cho, Chi Hin, Rudd, John A., Lin, Ge

“…Angelica sinensis is a Chinese medicinal herb for treating gynecological and gastrointestinal disorders, and also in conjunction with cancer chemotherapy. In…”
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Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice by Zeng, Xiaoyan, Cheung, Stanley K. K., Shi, Mengqi, Or, Penelope M. Y., Li, Zhining, Liu, Julia Y. H., Ho, Wayne L. H., Liu, Tian, Lu, Kun, Rudd, John A., Wang, Yubing, Chan, Andrew M.

“…Abstract Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer’s disease. YKL-40 is a…”
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Action of Bacopa monnieri to antagonize cisplatin-induced emesis in Suncus murinus (house musk shrew) by Ullah, Ihsan, Subhan, Fazal, Lu, Zengbing, Chan, Sze Wa, Rudd, John A.

“…Bacopa monnieri (BM, family Scrophulariaceae) is used in several traditional systems of medicine for the management of epilepsy, depression, neuropathic pain,…”
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Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia by Fang, Marong, Ling, Shucai, Davies, Henry, Li, Weiyun, Hu, Zhiying, Gao, Keqiang, Yang, Yang, Rudd, John A.

“…It has previously been demonstrated that ischemic stroke activates autophagy pathways; however, the mechanism remains unclear. The aim of this study is to…”
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Insights Into Acute and Delayed Cisplatin-Induced Emesis From a Microelectrode Array, Radiotelemetry and Whole-Body Plethysmography Study of Suncus murinus (House Musk Shrew) by Tu, Longlong, Liu, Julia Y H, Lu, Zengbing, Cui, Dexuan, Ngan, Man P, Du, Peng, Rudd, John A

“…Cancer patients receiving cisplatin therapy often experience side-effects such as nausea and emesis, but current anti-emetic regimens are suboptimal. Thus, to…”
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Gene expression changes in GABA(A) receptors and cognition following chronic ketamine administration in mice by Tan, Sijie, Rudd, John A, Yew, David T

“…Ketamine is a well-known anesthetic agent and a drug of abuse. Despite its widespread use and abuse, little is known about its long-term effects on the central…”
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The Actions of Centrally Administered Nesfatin-1 on Emesis, Feeding, and Locomotor Activity in Suncus murinus (House Musk Shrew) by Lu, Zengbing, Cui, Dexuan, Liu, Julia Yuen Hang, Jiang, Bin, Ngan, Man Piu, Sakata, Ichiro, Takemi, Shota, Sakai, Takafumi, Lin, Ge, Chan, Sze Wa, Rudd, John A

“…Nesfatin-1 is an anorectic peptide expressed in both peripheral tissues and brain areas involved in the regulation of feeding, emotion and emesis. The aim of…”
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Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms by Sin, Thomas K, Tam, Bjorn T, Yu, Angus P, Yip, Shea P, Yung, Benjamin Y, Chan, Lawrence W, Wong, Cesar S, Rudd, John A, Siu, Parco M

“…Study of the exacerbating effects of chemotherapeutics, such as doxorubicin, on the impairment of insulin metabolic signaling in aged skeletal muscle is very…”
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The differential antiemetic properties of GLP-1 receptor antagonist, exendin (9–39) in Suncus murinus (house musk shrew) by Chan, Sze Wa, Lu, Zengbing, Lin, Ge, Yew, David Tai Wai, Yeung, Chi Kong, Rudd, John A.

“…The use of glucagon-like peptide-1 (7–36) amide (GLP-1) receptor agonists for the treatment of type 2 diabetes mellitus is commonly associated with nausea and…”
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Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches by Lu, Zengbing, Zhou, Yu, Tu, Longlong, Chan, Sze Wa, Ngan, Man P, Cui, Dexuan, Liu, Yuen Hang Julia, Huang, Ianto Bosheng, Kung, Jeng S C, Hui, Chung Man Jessica, Rudd, John A

“…Nausea and emesis resulting from disease or drug treatment may be associated with disrupted gastric myoelectric activity (GMA). Conventional analytical…”
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Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT3 Antagonist, Palonosetron and With the NK1 Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in Suncus murinus (House Musk Shrew) by Rudd, John A., Chan, Sze W., Ngan, Man P., Tu, Longlong, Lu, Zengbing, Giuliano, Claudio, Lovati, Emanuela, Pietra, Claudio

“…Ghrelin has well-known activity to stimulate appetite and weight gain. Evidence suggests that ghrelin may also have effects in reducing chemotherapy-induced…”
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Separation of emetic and anorexic responses of exendin-4, a GLP-1 receptor agonist in Suncus murinus (house musk shrew) by Chan, Sze Wa, Lin, Ge, Yew, David Tai Wai, Yeung, Chi Kong, Rudd, John A.

“…The use of glucagon-like peptide-1 (7–36) amide (GLP-1) receptor agonists for the treatment of type 2 diabetes mellitus is commonly associated with nausea and…”
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Motion sickness, nausea and thermoregulation: The "toxic" hypothesis by Nalivaiko, Eugene, Rudd, John A, So, Richard HY

“…Principal symptoms of motion sickness in humans include facial pallor, nausea and vomiting, and sweating. It is less known that motion sickness also affects…”
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Thermoregulatory correlates of nausea in rats and musk shrews by Ngampramuan, Sukonthar, Cerri, Matteo, Del Vecchio, Flavia, Corrigan, Joshua J, Kamphee, Amornrat, Dragic, Alexander S, Rudd, John A, Romanovsky, Andrej A, Nalivaiko, Eugene

“…Nausea is a prominent symptom and major cause of complaint for patients receiving anticancer chemo- or radiation therapy. The arsenal of anti-nausea drugs is…”
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Brain Activation by H1 Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in Suncus murinus (House Musk Shrew) by Tu, Longlong, Lu, Zengbing, Dieser, Karolina, Schmitt, Christina, Chan, Sze Wa, Ngan, Man P., Andrews, Paul L. R., Nalivaiko, Eugene, Rudd, John A.

“…Motion sickness occurs under a variety of circumstances and is common in the general population. It is usually associated with changes in gastric motility, and…”
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