Search Results - "Rudd, G"

The effects of socioeconomic status on stroke risk and outcomes by Marshall, Iain J, Dr, Wang, Yanzhong, PhD, Crichton, Siobhan, MSc, McKevitt, Christopher, Prof, Rudd, Anthony G, Prof, Wolfe, Charles D A, Prof

“…Summary The latest evidence on socioeconomic status and stroke shows that stroke not only disproportionately affects low-income and middle-income countries,…”
Get full text

Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis by Ayerbe, Luis, Ayis, Salma, Wolfe, Charles D. A., Rudd, Anthony G.

“…Depression after stroke is a distressing problem that may be associated with other negative health outcomes. To estimate the natural history, predictors and…”
Get full text

Targeting the DNA damage response and repair in cancer through nucleotide metabolism by Helleday, Thomas, Rudd, Sean G.

“…The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of DNA…”
Get full text

A systematic review of machine learning models for predicting outcomes of stroke with structured data by Wang, Wenjuan, Kiik, Martin, Peek, Niels, Curcin, Vasa, Marshall, Iain J, Rudd, Anthony G, Wang, Yanzhong, Douiri, Abdel, Wolfe, Charles D, Bray, Benjamin

“…Background and purpose Machine learning (ML) has attracted much attention with the hope that it could make use of large, routinely collected datasets and…”
Get full text

Patient outcomes up to 15 years after stroke: survival, disability, quality of life, cognition and mental health by Crichton, Siobhan L, Bray, Benjamin D, McKevitt, Christopher, Rudd, Anthony G, Wolfe, Charles D A

“…BackgroundThe global epidemiological shift of disease burden towards long-term conditions means understanding long-term outcomes of cardiovascular disease is…”
Get full text

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication by Bianchi, Julie, Rudd, Sean G., Jozwiakowski, Stanislaw K., Bailey, Laura J., Soura, Violetta, Taylor, Elaine, Stevanovic, Irena, Green, Andrew J., Stracker, Travis H., Lindsay, Howard D., Doherty, Aidan J.

“…DNA damage can stall the DNA replication machinery, leading to genomic instability. Thus, numerous mechanisms exist to complete genome duplication in the…”
Get full text

Weekly variation in health-care quality by day and time of admission: a nationwide, registry-based, prospective cohort study of acute stroke care by Bray, Benjamin D, Dr, Cloud, Geoffrey C, FRCP, James, Martin A, FRCP, Hemingway, Harry, Prof, Paley, Lizz, BA, Stewart, Kevin, FRCP, Tyrrell, Pippa J, Prof, Wolfe, Charles D A, Prof, Rudd, Anthony G, Prof

“…Summary Background Studies in many health systems have shown evidence of poorer quality health care for patients admitted on weekends or overnight than for…”
Get full text

Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities by Rudd, Sean G.

“…Cytotoxic chemotherapy remains a key modality in cancer treatment. These therapies, successfully used for decades, continue to transform the lives of cancer…”
Get full text

Lacosamide as adjunctive therapy for partial‐onset seizures: A randomized controlled trial by Chung, Steve, Sperling, Michael R., Biton, Victor, Krauss, Gregory, Hebert, David, Rudd, G. David, Doty, Pamela

“…Summary Purpose:  To evaluate the efficacy and safety of lacosamide (400 and 600 mg/day) as adjunctive treatment in patients with uncontrolled partial‐onset…”
Get full text

Understanding the interplay between dNTP metabolism and genome stability in cancer by Yagüe-Capilla, Miriam, Rudd, Sean G

“…The size and composition of the intracellular DNA precursor pool is integral to the maintenance of genome stability, and this relationship is fundamental to…”
Get full text

The long-term outcomes of depression up to 10 years after stroke; the South London Stroke Register by Ayerbe, L, Ayis, S, Crichton, S, Wolfe, C D A, Rudd, A G

“…Background Post-stroke depression is a frequent chronic and recurrent problem that starts shortly after stroke and affects patients in the long term. The…”
Get full text

Estimates of outcomes up to ten years after stroke: analysis from the prospective South London Stroke Register by Wolfe, Charles D A, Crichton, Siobhan L, Heuschmann, Peter U, McKevitt, Christopher J, Toschke, André M, Grieve, Andy P, Rudd, Anthony G

“…Although stroke is acknowledged as a long-term condition, population estimates of outcomes longer term are lacking. Such estimates would be useful for planning…”
Get full text

Associations between stroke mortality and weekend working by stroke specialist physicians and registered nurses: prospective multicentre cohort study by Bray, Benjamin D, Ayis, Salma, Campbell, James, Cloud, Geoffrey C, James, Martin, Hoffman, Alex, Tyrrell, Pippa J, Wolfe, Charles D A, Rudd, Anthony G

“…Observational studies have reported higher mortality for patients admitted on weekends. It is not known whether this "weekend effect" is modified by clinical…”
Get full text

Efficacy and Safety of Oral Lacosamide as Adjunctive Therapy in Adults with Partial‐Onset Seizures by Ben‐Menachem, Elinor, Biton, Victor, Jatuzis, Dalius, Abou‐Khalil, Bassel, Doty, Pamela, Rudd, G. David

“…Purpose: To evaluate the efficacy and safety of lacosamide when added to 1 or 2 antiepileptic drugs (AEDs) in adults with uncontrolled partial‐onset seizures,…”
Get full text

Pathways controlling dNTP pools to maintain genome stability by Rudd, Sean G., Valerie, Nicholas C.K., Helleday, Thomas

“…Artificially modified nucleotides, in the form of nucleoside analogues, are widely used in the treatment of cancers and various other diseases, and have become…”
Get full text

PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome by Rudd, Sean G., Glover, Lucy, Jozwiakowski, Stanislaw K., Horn, David, Doherty, Aidan J.

“…Faithful copying of the genome is essential for life. In eukaryotes, a single archaeo-eukaryotic primase (AEP), DNA primase, is required for the initiation and…”
Get full text

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites by Herold, Nikolas, Rudd, Sean G., Sanjiv, Kumar, Kutzner, Juliane, Bladh, Julia, Paulin, Cynthia B. J., Helleday, Thomas, Henter, Jan-Inge, Schaller, Torsten

“…Recently, we demonstrated that sterile α motif and HD domain containing protein 1 (SAMHD1) is a major barrier in acute myelogenous leukemia (AML) cells to the…”
Get full text

Socioeconomic disparities in first stroke incidence, quality of care, and survival: a nationwide registry-based cohort study of 44 million adults in England by Bray, Benjamin D, Paley, Lizz, Hoffman, Alex, James, Martin, Gompertz, Patrick, Wolfe, Charles D A, Hemingway, Harry, Rudd, Anthony G

“…We aimed to estimate socioeconomic disparities in the incidence of hospitalisation for first-ever stroke, quality of care, and post-stroke survival for the…”
Get full text

Trends in prevalence of acute stroke impairments: A population-based cohort study using the South London Stroke Register by Clery, Amanda, Bhalla, Ajay, Rudd, Anthony G, Wolfe, Charles D A, Wang, Yanzhong

“…Acute stroke impairments often result in poor long-term outcome for stroke survivors. The aim of this study was to estimate the trends over time in the…”
Get full text

Drug synergy scoring using minimal dose response matrices by Mäkelä, Petri, Zhang, Si Min, Rudd, Sean G

“…Combinations of pharmacological agents are essential for disease control and prevention, offering many advantages over monotherapies, with one of these being…”
Get full text