Search Results - "Rudd, Brian D."

Shaping immunity for life: Layered development of CD8+ T cells by Tabilas, Cybelle, Smith, Norah L., Rudd, Brian D.

“…Summary Historically, the immune system was believed to develop along a linear axis of maturity from fetal life to adulthood. Now, it is clear that distinct…”
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Neonatal T Cells: A Reinterpretation by Rudd, Brian D

“…Neonatal CD4 + and CD8 + T cells have historically been characterized as immature or defective. However, recent studies prompt a reinterpretation of the…”
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Plasmacytoid dendritic cells inhibit pulmonary immunopathology and promote clearance of respiratory syncytial virus by Smit, Joost J, Rudd, Brian D, Lukacs, Nicholas W

“…Respiratory syncytial virus (RSV) infection is widely spread and is a major cause of bronchiolitis in infants and high-risk adults, often leading to…”
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Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions by Rudd, Brian D, Venturi, Vanessa, Li, Gang, Samadder, Partha, Ertelt, James M, Way, Sing Sing, Davenport, Miles P, Nikolich-žugich, Janko

“…Immunity against new infections declines in the last quartile of life, as do numbers of naive T cells. Peripheral maintenance of naive T cells over the…”
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Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire by Rudd, Brian D, Venturi, Vanessa, Davenport, Miles P, Nikolich-Zugich, Janko

“…Defects in T cell responses against pathogens and reduced diversity of TCRs have been described at both extremes of the life span. Yet, we still lack…”
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Differential Role for TLR3 in Respiratory Syncytial Virus-Induced Chemokine Expression by Rudd, Brian D, Burstein, Ezra, Duckett, Colin S, Li, Xiaoxia, Lukacs, Nicholas W

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses by Rudd, Brian D, Venturi, Vanessa, Smith, Norah L, Nzingha, Kito, Goldberg, Emily L, Li, Gang, Nikolich-Zugich, Janko, Davenport, Miles P

“…Microbial infection during various stages of human development produces widely different clinical outcomes, yet the links between age-related changes in the…”
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Deletion of TLR3 Alters the Pulmonary Immune Environment and Mucus Production during Respiratory Syncytial Virus Infection by Rudd, Brian D, Smit, Jetse J, Flavell, Richard A, Alexopoulou, Lena, Schaller, Matthew A, Gruber, Achim, Berlin, Aaron A, Lukacs, Nicholas W

“…The detection of a viral infection by pattern recognition receptors (PAMPs) is an integral part of antiviral immunity. In these studies we have investigated…”
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Differential Immune Responses and Pulmonary Pathophysiology Are Induced by Two Different Strains of Respiratory Syncytial Virus by Lukacs, Nicholas W., Moore, Martin L., Rudd, Brian D., Berlin, Aaron A., Collins, Robert D., Olson, Sandra J., Ho, Samuel B., Peebles, R. Stokes

“…In this study we performed comparisons of pulmonary responses between two different respiratory syncytial virus (RSV) antigenic subgroup A strains, A2 and Line…”
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Building a T cell compartment: how immune cell development shapes function by Davenport, Miles P., Smith, Norah L., Rudd, Brian D.

“…We are just beginning to understand the diversity of the peripheral T cell compartment, which arises from the specialization of different T cell subsets and…”
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MyD88-Mediated Instructive Signals in Dendritic Cells Regulate Pulmonary Immune Responses during Respiratory Virus Infection by Rudd, Brian D, Schaller, Matthew A, Smit, Joost J, Kunkel, Steven L, Neupane, Rupak, Kelley, Lara, Berlin, Aaron A, Lukacs, Nicholas W

“…Respiratory syncytial virus (RSV) is the leading cause of respiratory disease in infants worldwide. The induction of innate immunity and the establishment of…”
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Developmental Origin Governs CD8+ T Cell Fate Decisions during Infection by Smith, Norah L., Patel, Ravi K., Reynaldi, Arnold, Grenier, Jennifer K., Wang, Jocelyn, Watson, Neva B., Nzingha, Kito, Yee Mon, Kristel J., Peng, Seth A., Grimson, Andrew, Davenport, Miles P., Rudd, Brian D.

“…Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following infection, naive T cells differentiate into various subsets of…”
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Fate-mapping mice: new tools and technology for immune discovery by Lee, Scarlett E., Rudd, Brian D., Smith, Norah L.

“…The fate-mapping mouse has become an essential tool in the immunologist’s toolbox. Although traditionally used by developmental biologists to trace the origins…”
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Fetal and adult progenitors give rise to unique populations of CD8+ T cells by Wang, Jocelyn, Wissink, Erin M., Watson, Neva B., Smith, Norah L., Grimson, Andrew, Rudd, Brian D.

“…During the ontogeny of the mammalian immune system, distinct lineages of cells arise from fetal and adult hematopoietic stem cells (HSCs) during specific…”
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Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells by Yee Mon, Kristel J., Kim, Sungwoong, Dai, Zhonghao, West, Jessica D., Zhu, Hongya, Jain, Ritika, Grimson, Andrew, Rudd, Brian D., Singh, Ankur

“…Cellular programming of naïve T cells can improve the efficacy of adoptive T-cell therapy. However, the current ex vivo engineering of T cells requires the…”
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miR-150 Regulates Differentiation and Cytolytic Effector Function in CD8+ T cells by Smith, Norah L., Wissink, Erin M., Grimson, Andrew, Rudd, Brian D.

“…MicroRNAs regulate most mammalian genes and they control numerous aspects of immune system development and function. Their precise roles in the CD8+ T cell…”
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Cutting Edge: Retinoic Acid Promotes Brain-homing of CD8+ T Cells during Congenital Cytomegalovirus Infection by Hilt, Zachary T, Charles, Wisler, Ali, Taha, Smith, Casey V, Zhang, Shide, Wesnak, Samantha P, Smith, Norah L, Rudd, Brian D

“…The most common congenital viral infection is CMV, which leads to numerous neurologic disabilities. Using a mouse model of congenital CMV, we previously…”
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Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8 + T Cells in Early Life by Tabilas, Cybelle, Wang, Jocelyn, Liu, Xiaojing, Locasale, Jason W, Smith, Norah L, Rudd, Brian D

“…Neonates often develop poor immunity against intracellular pathogens. Because CD8 T cells are essential for eliminating infectious agents, it is crucial to…”
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Ccr2+ Monocyte-Derived Macrophages Influence Trajectories of Acquired Therapy Resistance in Braf-Mutant Melanoma by Kim, Dahihm, An, Luye, Moon, Jiwon, Maymi, Viviana I, McGurk, Alexander I, Rudd, Brian D, Fowell, Deborah J, White, Andrew C

“…Therapies targeting oncogene addiction have had a tremendous impact on tumor growth and patient outcome, but drug resistance continues to be problematic. One…”
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Fate mapping reveals the age structure of the peripheral T cell compartment by Reynaldi, Arnold, Smith, Norah L., Schlub, Timothy E., Tabilas, Cybelle, Venturi, Vanessa, Rudd, Brian D., Davenport, Miles P.

“…Accumulating evidence indicates that the immune system does not develop in a linear fashion, but rather as distinct developmental layers formed from sequential…”
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