Search Results - "Rudack, Till"

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment by Guo, Qiang, Lehmer, Carina, Martínez-Sánchez, Antonio, Rudack, Till, Beck, Florian, Hartmann, Hannelore, Pérez-Berlanga, Manuela, Frottin, Frédéric, Hipp, Mark S., Hartl, F. Ulrich, Edbauer, Dieter, Baumeister, Wolfgang, Fernández-Busnadiego, Rubén

“…Protein aggregation and dysfunction of the ubiquitin-proteasome system are hallmarks of many neurodegenerative diseases. Here, we address the elusive link…”
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Structure of the human 26S proteasome at a resolution of 3.9 Å by Schweitzer, Andreas, Aufderheide, Antje, Rudack, Till, Beck, Florian, Pfeifer, Günter, Plitzko, Jürgen M., Sakata, Eri, Schulten, Klaus, Förster, Friedrich, Baumeister, Wolfgang

“…Protein degradation in eukaryotic cells is performed by the Ubiquitin-Proteasome System (UPS). The 26S proteasome holocomplex consists of a core particle (CP)…”
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Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity by Gupta, Tilak Kumar, Klumpe, Sven, Gries, Karin, Heinz, Steffen, Wietrzynski, Wojciech, Ohnishi, Norikazu, Niemeyer, Justus, Spaniol, Benjamin, Schaffer, Miroslava, Rast, Anna, Ostermeier, Matthias, Strauss, Mike, Plitzko, Jürgen M., Baumeister, Wolfgang, Rudack, Till, Sakamoto, Wataru, Nickelsen, Jörg, Schuller, Jan M., Schroda, Michael, Engel, Benjamin D.

“…Vesicle-inducing protein in plastids 1 (VIPP1) is essential for the biogenesis and maintenance of thylakoid membranes, which transform light into life…”
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QwikMD — Integrative Molecular Dynamics Toolkit for Novices and Experts by Ribeiro, João V., Bernardi, Rafael C., Rudack, Till, Stone, John E., Phillips, James C., Freddolino, Peter L., Schulten, Klaus

“…The proper functioning of biomolecules in living cells requires them to assume particular structures and to undergo conformational changes. Both biomolecular…”
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Allosteric control of Ubp6 and the proteasome via a bidirectional switch by Hung, Ka Ying Sharon, Klumpe, Sven, Eisele, Markus R., Elsasser, Suzanne, Tian, Geng, Sun, Shuangwu, Moroco, Jamie A., Cheng, Tat Cheung, Joshi, Tapan, Seibel, Timo, Van Dalen, Duco, Feng, Xin-Hua, Lu, Ying, Ovaa, Huib, Engen, John R., Lee, Byung-Hoon, Rudack, Till, Sakata, Eri, Finley, Daniel

“…The proteasome recognizes ubiquitinated proteins and can also edit ubiquitin marks, allowing substrates to be rejected based on ubiquitin chain topology. In…”
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Structural insights into photosystem II assembly by Zabret, Jure, Bohn, Stefan, Schuller, Sandra K., Arnolds, Oliver, Möller, Madeline, Meier-Credo, Jakob, Liauw, Pasqual, Chan, Aaron, Tajkhorshid, Emad, Langer, Julian D., Stoll, Raphael, Krieger-Liszkay, Anja, Engel, Benjamin D., Rudack, Till, Schuller, Jan M., Nowaczyk, Marc M.

“…Biogenesis of photosystem II (PSII), nature’s water-splitting catalyst, is assisted by auxiliary proteins that form transient complexes with PSII components to…”
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Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating by Eisele, Markus R., Reed, Randi G., Rudack, Till, Schweitzer, Andreas, Beck, Florian, Nagy, Istvan, Pfeifer, Günter, Plitzko, Jürgen M., Baumeister, Wolfgang, Tomko, Robert J., Sakata, Eri

“…The proteasome is the central protease for intracellular protein breakdown. Coordinated binding and hydrolysis of ATP by the six proteasomal ATPase subunits…”
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Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations by Rudack, Till, Xia, Fei, Schlitter, Jürgen, Kötting, Carsten, Gerwert, Klaus

“…Members of the Ras superfamily regulate many cellular processes. They are down-regulated by a GTPase reaction in which GTP is cleaved into GDP and P ᵢ by…”
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Computational Methodologies for Real-Space Structural Refinement of Large Macromolecular Complexes by Goh, Boon Chong, Hadden, Jodi A, Bernardi, Rafael C, Singharoy, Abhishek, McGreevy, Ryan, Rudack, Till, Cassidy, C. Keith, Schulten, Klaus

“…The rise of the computer as a powerful tool for model building and refinement has revolutionized the field of structure determination for large biomolecular…”
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Lamprey Parapinopsin (“UVLamP”): a Bistable UV‐Sensitive Optogenetic Switch for Ultrafast Control of GPCR Pathways by Eickelbeck, Dennis, Rudack, Till, Tennigkeit, Stefan Alexander, Surdin, Tatjana, Karapinar, Raziye, Schwitalla, Jan‐Claudius, Mücher, Brix, Shulman, Maiia, Scherlo, Marvin, Althoff, Philipp, Mark, Melanie D., Gerwert, Klaus, Herlitze, Stefan

“…Optogenetics uses light‐sensitive proteins, so‐called optogenetic tools, for highly precise spatiotemporal control of cellular states and signals. The major…”
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Time-resolved spectroscopic and electrophysiological data reveal insights in the gating mechanism of anion channelrhodopsin by Dreier, Max-Aylmer, Althoff, Philipp, Norahan, Mohamad Javad, Tennigkeit, Stefan Alexander, El-Mashtoly, Samir F., Lübben, Mathias, Kötting, Carsten, Rudack, Till, Gerwert, Klaus

“…Channelrhodopsins are widely used in optogenetic applications. High photocurrents and low current inactivation levels are desirable. Two parallel photocycles…”
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A scale-spanning integrative modeling strategy to study structure, dynamics, and function of vital molecular machines by Rudack, Till

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The specific vibrational modes of GTP in solution and bound to Ras: a detailed theoretical analysis by QM/MM simulations by Xia, Fei, Rudack, Till, Kötting, Carsten, Schlitter, Jürgen, Gerwert, Klaus

“…The hydrolysis of guanosine triphosphate (GTP) in general, and especially by GTPases like the Ras protein, is in the focus of biological investigations. A huge…”
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The Protein Recycling Machine of the Cell - Insights through a Novel Hybrid Integrative Modeling Approach by Rudack, Till

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PyContact: Rapid, Customizable, and Visual Analysis of Noncovalent Interactions in MD Simulations by Scheurer, Maximilian, Rodenkirch, Peter, Siggel, Marc, Bernardi, Rafael C., Schulten, Klaus, Tajkhorshid, Emad, Rudack, Till

“…Molecular dynamics (MD) simulations have become ubiquitous in all areas of life sciences. The size and model complexity of MD simulations are rapidly growing…”
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Molecular dynamics simulations of large macromolecular complexes by Perilla, Juan R, Goh, Boon Chong, Cassidy, C Keith, Liu, Bo, Bernardi, Rafael C, Rudack, Till, Yu, Hang, Wu, Zhe, Schulten, Klaus

“…[Display omitted] •Advances in MD and imaging enable structural determination of large complexes.•Large-scale MD is essential to the atomic level description…”
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Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle by Majumder, Parijat, Rudack, Till, Beck, Florian, Danev, Radostin, Pfeifer, Günter, Nagy, István, Baumeister, Wolfgang

“…Proteasomes occur in all three domains of life, and are the principal molecular machines for the regulated degradation of intracellular proteins. They play key…”
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Insights into the assembly and activation of the microtubule nucleator γ-TuRC by Liu, Peng, Zupa, Erik, Neuner, Annett, Böhler, Anna, Loerke, Justus, Flemming, Dirk, Ruppert, Thomas, Rudack, Till, Peter, Christoph, Spahn, Christian, Gruss, Oliver J., Pfeffer, Stefan, Schiebel, Elmar

“…Microtubules are dynamic polymers of α- and β-tubulin and have crucial roles in cell signalling, cell migration, intracellular transport and chromosome…”
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Structural insights into the functional cycle of the ATPase module of the 26S proteasome by Wehmer, Marc, Rudack, Till, Beck, Florian, Aufderheide, Antje, Pfeifer, Günter, Plitzko, Jürgen M., Förster, Friedrich, Schulten, Klaus, Baumeister, Wolfgang, Sakata, Eri

“…In eukaryotic cells, the ubiquitin–proteasome system (UPS) is responsible for the regulated degradation of intracellular proteins. The 26S holocomplex…”
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N-Ras Forms Dimers at POPC Membranes by Güldenhaupt, Jörn, Rudack, Till, Bachler, Peter, Mann, Daniel, Triola, Gemma, Waldmann, Herbert, Kötting, Carsten, Gerwert, Klaus

“…Ras is a central regulator of cellular signaling pathways. It is mutated in 20–30% of human tumors. To perform its function, Ras has to be bound to a membrane…”
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