Search Results - "Ruck, Tobias"

Skeletal muscle as potential central link between sarcopenia and immune senescence by Nelke, Christopher, Dziewas, Rainer, Minnerup, Jens, Meuth, Sven G., Ruck, Tobias

“…As our population grows older, age-related pathologies are becoming more prevalent. Deterioration of skeletal muscle and the immune system manifests as…”
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Alemtuzumab in Multiple Sclerosis: Mechanism of Action and Beyond by Ruck, Tobias, Bittner, Stefan, Wiendl, Heinz, Meuth, Sven G

“…Alemtuzumab is a humanized monoclonal antibody against CD52 (cluster of differentiation 52) and is approved for the therapy of relapsing-remitting multiple…”
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Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society by Melzer, Nico, Ruck, Tobias, Fuhr, Peter, Gold, Ralf, Hohlfeld, Reinhard, Marx, Alexander, Melms, Arthur, Tackenberg, Björn, Schalke, Berthold, Schneider-Gold, Christiane, Zimprich, Fritz, Meuth, Sven G., Wiendl, Heinz

“…Myasthenia gravis (MG) is an autoimmune antibody-mediated disorder of neuromuscular synaptic transmission. The clinical hallmark of MG consists of fluctuating…”
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Understanding the burden of refractory myasthenia gravis by Schneider-Gold, Christiane, Hagenacker, Tim, Melzer, Nico, Ruck, Tobias

“…Myasthenia gravis (MG) is an autoantibody-mediated disease that compromises the acetylcholine receptors or associated structures of the postsynaptic membrane…”
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Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease by Schröder, Jens B, Pawlowski, Matthias, Meyer Zu Hörste, Gerd, Gross, Catharina C, Wiendl, Heinz, Meuth, Sven G, Ruck, Tobias, Warnecke, Tobias

“…Parkinson's disease (PD) is a common neurodegenerative disorder. The contribution of the immune system to its pathogenesis remains incompletely understood. In…”
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Independent risk factors for myasthenic crisis and disease exacerbation in a retrospective cohort of myasthenia gravis patients by Nelke, Christopher, Stascheit, Frauke, Eckert, Carmen, Pawlitzki, Marc, Schroeter, Christina B, Huntemann, Niklas, Mergenthaler, Philipp, Arat, Ercan, Öztürk, Menekse, Foell, Dirk, Schreiber, Stefanie, Vielhaber, Stefan, Gassa, Asmae, Stetefeld, Henning, Schroeter, Michael, Berger, Benjamin, Totzeck, Andreas, Hagenacker, Tim, Meuth, Sven G, Meisel, Andreas, Wiendl, Heinz, Ruck, Tobias

“…Myasthenic crisis (MC) and disease exacerbation in myasthenia gravis (MG) are associated with significant lethality and continue to impose a high disease…”
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Sequestosome‐1 (p62) expression reveals chaperone‐assisted selective autophagy in immune‐mediated necrotizing myopathies by Fischer, Norina, Preuße, Corinna, Radke, Josefine, Pehl, Debora, Allenbach, Yves, Schneider, Udo, Feist, Eugen, Casteleyn, Vincent, Hahn, Katrin, Ruck, Tobias, Meuth, Sven G., Goebel, Hans‐Hilmar, Graf, Rose, Mammen, Andrew, Benveniste, Olivier, Stenzel, Werner

“…Diffuse myofiber necrosis in the context of inflammatory myopathy is the hallmark of immune‐mediated necrotizing myopathy (IMNM). We have previously shown that…”
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Effect of Capsaicinoids on Neurophysiological, Biochemical, and Mechanical Parameters of Swallowing Function by Suntrup-Krueger, Sonja, Muhle, Paul, Kampe, Isabella, Egidi, Paula, Ruck, Tobias, Lenze, Frank, Jungheim, Michael, Gminski, Richard, Labeit, Bendix, Claus, Inga, Warnecke, Tobias, Gross, Joachim, Dziewas, Rainer

“…Oropharyngeal dysphagia is prevalent in age-related neurological disorders presenting with impaired efficacy and safety of swallowing due to a loss of muscle…”
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Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells by Göbel, Kerstin, Pankratz, Susann, Asaridou, Chloi-Magdalini, Herrmann, Alexander M., Bittner, Stefan, Merker, Monika, Ruck, Tobias, Glumm, Sarah, Langhauser, Friederike, Kraft, Peter, Krug, Thorsten F., Breuer, Johanna, Herold, Martin, Gross, Catharina C., Beckmann, Denise, Korb-Pap, Adelheid, Schuhmann, Michael K., Kuerten, Stefanie, Mitroulis, Ioannis, Ruppert, Clemens, Nolte, Marc W., Panousis, Con, Klotz, Luisa, Kehrel, Beate, Korn, Thomas, Langer, Harald F., Pap, Thomas, Nieswandt, Bernhard, Wiendl, Heinz, Chavakis, Triantafyllos, Kleinschnitz, Christoph, Meuth, Sven G.

“…Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence…”
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Impact of Diverse Ion Channels on Regulatory T Cell Functions by Vinnenberg, Laura, Bock, Stefanie, Hundehege, Petra, Ruck, Tobias, Meuth, Sven G

“…The population of regulatory T cells (Tregs) is critical for immunological self-tolerance and homeostasis. Proper ion regulation contributes to Treg lineage…”
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Enjoy Carefully: The Multifaceted Role of Vitamin E in Neuro-Nutrition by Regner-Nelke, Liesa, Nelke, Christopher, Schroeter, Christina B., Dziewas, Rainer, Warnecke, Tobias, Ruck, Tobias, Meuth, Sven G.

“…Vitamin E is often associated with health benefits, such as antioxidant, anti-inflammatory and cholesterol-lowering effects. These properties make its…”
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Pathophysiological Role of K2P Channels in Human Diseases by Lee, Li-Ming, Müntefering, Thomas, Budde, Thomas, Meuth, Sven G, Ruck, Tobias

“…The family of two-pore domain potassium (K2P) channels is critically involved in central cellular functions such as ion homeostasis, cell development, and…”
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Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis by Preuße, Corinna, Paesler, Barbara, Nelke, Christopher, Cengiz, Derya, Müntefering, Thomas, Roos, Andreas, Amelin, Damien, Allenbach, Yves, Uruha, Akinori, Dittmayer, Carsten, Hentschel, Andreas, Pawlitzki, Marc, Hoffmann, Sarah, Timm, Sara, Louis, Sarah Leonard, Dengler, Nora F., Wiendl, Heinz, Lünemann, Jan D., Sickmann, Albert, Hervier, Baptiste, Meuth, Sven G., Schneider, Udo, Schänzer, Anne, Krause, Sabine, Tomaras, Stylianos, Feist, Eugen, Hasseli, Rebecca, Goebel, Hans-Hilmar, Gallay, Laure, Streichenberger, Nathalie, Benveniste, Olivier, Stenzel, Werner, Ruck, Tobias

“…Anti-synthetase syndrome (ASyS)-associated myositis is a major subgroup of the idiopathic inflammatory myopathies (IIM) and is characterized by disease…”
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Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders by Brummer, Tobias, Ruck, Tobias, Meuth, Sven G., Zipp, Frauke, Bittner, Stefan

“…The past decades have yielded major therapeutic advances in many autoimmune conditions – such as multiple sclerosis (MS) – and thus ushered in a new era of…”
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Isolation of primary murine brain microvascular endothelial cells by Ruck, Tobias, Bittner, Stefan, Epping, Lisa, Herrmann, Alexander M, Meuth, Sven G

“…The blood-brain-barrier is ultrastructurally assembled by a monolayer of brain microvascular endothelial cells (BMEC) interconnected by a junctional complex of…”
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S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration by Sindi, Mustafa, Hecker, Christina, Issberner, Andrea, Ruck, Tobias, Meuth, Sven G., Albrecht, Philipp, Dietrich, Michael

“…Introduction In multiple sclerosis (MS), chronic disability primarily stems from axonal and neuronal degeneration, a condition resistant to conventional…”
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Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses by Pfeuffer, Steffen, Rolfes, Leoni, Wirth, Timo, Steffen, Falk, Pawlitzki, Marc, Schulte-Mecklenbeck, Andreas, Gross, Catharina C, Brand, Marcus, Bittner, Stefan, Ruck, Tobias, Klotz, Luisa, Wiendl, Heinz, Meuth, Sven G

“…Abstract Objective Intravenous methylprednisolone is the standard treatment for a multiple sclerosis relapse; however, this fails to improve symptoms in up to…”
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TRPC6 channels modulate the response of pancreatic stellate cells to hypoxia by Nielsen, Nikolaj, Kondratska, Kateryna, Ruck, Tobias, Hild, Benedikt, Kovalenko, Ilya, Schimmelpfennig, Sandra, Welzig, Jana, Sargin, Sarah, Lindemann, Otto, Christian, Sven, Meuth, Sven G., Prevarskaya, Natalia, Schwab, Albrecht

“…Pancreatic cancer is characterized by a massive fibrosis (desmoplasia), which is primarily caused by activated pancreatic stellate cells (PSCs). This leads to…”
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Animal models in idiopathic inflammatory myopathies: How to overcome a translational roadblock? by Afzali, Ali, Ruck, Tobias, Wiendl, Heinz, Meuth, Sven G

“…Abstract Idiopathic inflammatory myopathies (IIMs) encompass a heterogenic group of rare muscle diseases with common symptoms including muscle weakness and the…”
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Molecular composition of skeletal muscle in infants and adults: a comparative proteomic and transcriptomic study by Schaiter, Alexander, Hentschel, Andreas, Kleefeld, Felix, Schuld, Julia, Umathum, Vincent, Procida-Kowalski, Tara, Nelke, Christopher, Roth, Angela, Hahn, Andreas, Krämer, Heidrun H., Ruck, Tobias, Horvath, Rita, van der Ven, Peter F. M., Bartkuhn, Marek, Roos, Andreas, Schänzer, Anne

“…To gain a deeper understanding of skeletal muscle function in younger age and aging in elderly, identification of molecular signatures regulating these…”
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