Search Results - "Ruby L. C. Hoo"

Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice by Cheong, Lai Yee, Wang, Baile, Wang, Qin, Jin, Leigang, Kwok, Kelvin H. M., Wu, Xiaoping, Shu, Lingling, Lin, Huige, Chung, Sookja Kim, Cheng, Kenneth K. Y., Hoo, Ruby L. C., Xu, Aimin

“…Lymph nodes (LNs) are always embedded in the metabolically-active white adipose tissue (WAT), whereas their functional relationship remains obscure. Here, we…”
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Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction by Zhou, Mi, Bao, Yuqian, Li, Haobo, Pan, Yong, Shu, Lingling, Xia, Zhengyuan, Wu, Donghai, Lam, Karen S L, Vanhoutte, Paul M, Xu, Aimin, Jia, Weiping, Hoo, Ruby L-C

“…Clinical evidence shows that circulating levels of adipocyte fatty-acid-binding protein (A-FABP) are elevated in patients with diabetes and closely associated…”
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Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans by Wang, Yu, Lam, Karen S. L, Kraegen, Edward W, Sweeney, Gary, Zhang, Jialiang, Tso, Annette W.K, Chow, Wing-Sun, Wat, Nelson M.S, Xu, Jian Yu, Hoo, Ruby L.C, Xu, Aimin

“…Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for early detection of various renal injuries. Because lipocalin-2 is abundantly expressed…”
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Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice by Xu, Aimin, Wang, Hongbing, Hoo, Ruby L. C, Sweeney, Gary, Vanhoutte, Paul. M, Wang, Yu, Wu, Donghai, Chu, Wenjing, Qin, Guowei, Lam, Karen S. L

“…Adiponectin is an adipocyte-derived insulin-sensitizing hormone with antidiabetic, antiinflammatory, and antiatherosclerotic properties. A decreased serum…”
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Resistin production from adipose tissue is decreased in db/db obese mice, and is reversed by rosiglitazone by Ye, Hongying, Zhang, Herbert J, Xu, Aimin, Hoo, Ruby L C

“…This study was designed to (1) investigate the expression profiles of resistin in db/db mice and its dynamic association with metabolic parameters; and (2)…”
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Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury by Zhou, Mingyan, Xu, Aimin, Tam, Paul K. H., Lam, Karen S. L., Chan, Lawrence, Hoo, Ruby L. C., Liu, Jing, Chow, Kim H. M., Wang, Yu

“…Adiponectin is an adipocyte‐derived hormone with a wide range of beneficial effects on obesity‐related medical complications. Numerous epidemiological…”
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Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin by Yau, Suk Yu, Li, Ang, Hoo, Ruby L. C., Ching, Yick Pang, Christie, Brian R., Lee, Tatia M. C., Xu, Aimin, So, Kwok-Fai

“…Adiponectin (ADN) is an adipocyte-secreted protein with insulin-sensitizing, antidiabetic, antiinflammatory, and antiatherogenic properties. Evidence is also…”
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Post-translational Modifications of the Four Conserved Lysine Residues within the Collagenous Domain of Adiponectin Are Required for the Formation of Its High Molecular Weight Oligomeric Complex by Wang, Yu, Lam, Karen S.L., Chan, Lawrence, Chan, Kok Weng, Lam, Janice B.B., Lam, Michael C., Hoo, Ruby C.L., Mak, William W.N., Cooper, Garth J.S., Xu, Aimin

“…Adiponectin is a multifunctional adipokine that circulates as several oligomeric complexes in the blood stream. However, the molecular basis that regulates the…”
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Angiopoietin-Like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice by Xu, Aimin, Lam, Michael C., Chan, Kok Weng, Wang, Yu, Zhang, Jialiang, Ruby L. C. Hoo, Xu, Jian Yu, Chen, Baoying, Chow, Wing-Sun, Annette W. K. Tso, Karen S. L. Lam, Unger, Roger H.

“…Angiopoietin-like protein 4 (ANGPTL4) is a circulating protein predominantly expressed in adipose tissue and liver. Several recent studies demonstrated that…”
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Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood–brain barrier by Liao, Boya, Geng, Leiluo, Zhang, Fang, Shu, Lingling, Wei, Ling, Yeung, Patrick K K, Lam, Karen S L, Chung, Sookja K, Chang, Junlei, Vanhoutte, Paul M, Xu, Aimin, Wang, Kai, Hoo, Ruby L C

“…Abstract Aims Adipocyte fatty acid-binding protein (A-FABP) is an adipokine implicating in various metabolic diseases. Elevated circulating levels of A-FABP…”
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TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt by Cheng, Kenneth K Y, Lam, Karen S L, Wang, Yu, Wu, Donghai, Zhang, Mingliang, Wang, Baile, Li, Xiaomu, Hoo, Ruby L C, Huang, Zhe, Sweeney, Gary, Xu, Aimin

“…Insulin inhibits hepatic glucose production through activation of the protein kinase Akt, and any defect in this pathway causes fasting hyperglycaemia in Type…”
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A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes by Shu, Lingling, Hoo, Ruby L. C., Wu, Xiaoping, Pan, Yong, Lee, Ida P. C., Cheong, Lai Yee, Bornstein, Stefan R, Rong, Xianglu, Guo, Jiao, Xu, Aimin

“…The adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications. Here we show that A-FABP…”
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CRAF Methylation by PRMT6 Regulates Aerobic Glycolysis–Driven Hepatocarcinogenesis via ERK‐Dependent PKM2 Nuclear Relocalization and Activation by Wong, Tin‐Lok, Ng, Kai‐Yu, Tan, Kel Vin, Chan, Lok‐Hei, Zhou, Lei, Che, Noélia, Hoo, Ruby L.C., Lee, Terence K., Richard, Stéphane, Lo, Chung‐Mau, Man, Kwan, Khong, Pek‐Lan, Ma, Stephanie

“…Background and Aims Most tumor cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and promote tumorigenicity and drug resistance…”
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Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells by Wu, Xiaoping, Shu, Lingling, Zhang, Zixuan, Li, Jingjing, Zong, Jiuyu, Cheong, Lai Yee, Ye, Dewei, Lam, Karen S. L., Song, Erfei, Wang, Cunchuan, Xu, Aimin, Hoo, Ruby L. C.

“…Development of liver fibrosis results in drastic changes in the liver microenvironment, which in turn accelerates disease progression. Although the…”
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The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells by Li, Xiaomu, Cheng, Kenneth K. Y., Liu, Zhuohao, Yang, Jin-Kui, Wang, Baile, Jiang, Xue, Zhou, Yawen, Hallenborg, Philip, Hoo, Ruby L. C., Lam, Karen S. L., Ikeda, Yasuhiro, Gao, Xin, Xu, Aimin

“…Mitochondrial metabolism is pivotal for glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells. However, little is known about the molecular…”
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APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice by Cheng, Kenneth K. Y., Lam, Karen S. L., Wu, Donghai, Wang, Yu, Sweeney, Gary, Hoo, Ruby L. C., Zhang, Jialiang, Xu, Aimin

“…Insulin resistance and defective insulin secretion are the two major features of type 2 diabetes. The adapter protein APPL1 is an obligatory molecule in…”
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Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy by Hoo, Ruby L. C., Shu, Lingling, Cheng, Kenneth K. Y., Wu, Xiaoping, Liao, Boya, Wu, Donghai, Zhou, Zhiguang, Xu, Aimin

“…Lipotoxicity is implicated in the pathogenesis of obesity-related inflammatory complications by promoting macrophage infiltration and activation. Endoplasmic…”
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Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice by Hoo, Ruby L.C, Lee, Ida P.C, Zhou, Mi, Wong, Janice Y.L, Hui, Xiaoyan, Xu, Aimin, Lam, Karen S.L

“…Background & Aims Adipocyte fatty acid binding protein (A-FABP) is a key mediator of inflammatory response in macrophages. Increased hepatic expression and…”
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Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action by Liu, Ying, Sen, Sanjana, Wannaiampikul, Sivaporn, Palanivel, Rengasamy, Hoo, Ruby L C, Isserlin, Ruth, Bader, Gary D, Tungtrongchitr, Rungsunn, Deshaies, Yves, Xu, Aimin, Sweeney, Gary

“…Adiponectin mediates anti-diabetic effects via increasing hepatic insulin sensitivity and direct metabolic effects. In the present study, we conducted a…”
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Oct-1 Is Involved in the Transcriptional Repression of the Gonadotropin-Releasing Hormone Receptor Gene by Cheng, Chi Keung, Yeung, Chung Man, Hoo, Ruby L. C, Chow, Billy K. C, Leung, Peter C. K

“…Previous deletion analysis of the 5′-flanking region of human GnRH receptor (GnRHR) gene has revealed a powerful negative regulatory element (NRE) located…”
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