Search Results - "Rubio, Modesto C."

Efavirenz is a substrate and in turn modulates the expression of the efflux transporter ABCG2/BCRP in the gastrointestinal tract of the rat by Peroni, Roxana N., Di Gennaro, Stefania S., Hocht, Christian, Chiappetta, Diego A., Rubio, Modesto C., Sosnik, Alejandro, Bramuglia, Guillermo F.

“…The oral bioavailability of the antiretroviral efavirenz (EFV) undergoes high inter and intra-individual variability, this fact supporting its therapeutic drug…”
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Acetaminophen inhibits intestinal p-glycoprotein transport activity by Novak, Analia, Carpini, Griselda Delli, Ruiz, María Laura, Luquita, Marcelo G, Rubio, Modesto C, Mottino, Aldo D, Ghanem, Carolina I

“…Repeated acetaminophen (AP) administration modulates intestinal P-glycoprotein (P-gp) expression. Whether AP can modulate P-gp activity in a short-term fashion…”
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Tetronic® 904-containing polymeric micelles overcome the overexpression of ABCG2 in the blood-brain barrier of rats and boost the penetration of the antiretroviral efavirenz into the CNS by Roma, Martín I, Hocht, Christian, Chiappetta, Diego A, Di Gennaro, Stefania S, Minoia, Juan M, Bramuglia, Guillermo F, Rubio, Modesto C, Sosnik, Alejandro, Peroni, Roxana N

“…To assess the involvement of ABCG2 in the pharmacokinetics of efavirenz in the blood-brain barrier (BBB) and investigate a nanotechnology strategy to overcome…”
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Episcleral Implants for Topotecan Delivery to the Posterior Segment of the Eye by Carcaboso, Angel M, Chiappetta, Diego A, Opezzo, Javier A. W, Hocht, Christian, Fandino, Adriana C, Croxatto, J. Oscar, Rubio, Modesto C, Sosnik, Alejandro, Abramson, David H, Bramuglia, Guillermo F, Chantada, Guillermo L

“…Purpose. Intravenous or periocular topotecan has been proposed as new treatment modality for patients with advanced intraocular retinoblastoma, but systemic…”
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Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line by Ghanem, Carolina I., Arias, Agostina, Novak, Analia, Carpini, Griselda Delli, Villanueva, Silvina, Blazquez, Alba G., Marin, Jose J.G., Mottino, Aldo D., Rubio, Modesto C.

“…The well-known analgesic and antipyretic drug N-acetyl- p-aminophenol (acetaminophen; APAP) has been previously reported to affect MDR1 expression in rat…”
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Topotecan Vitreous Levels after Periocular or Intravenous Delivery in Rabbits: An Alternative for Retinoblastoma Chemotherapy by Carcaboso, Angel M, Bramuglia, Guillermo F, Chantada, Guillermo L, Fandino, Adriana C, Chiappetta, Diego A, de Davila, Maria T. G, Rubio, Modesto C, Abramson, David H

“…To determine the extent and the mechanism by which topotecan, a candidate agent for the treatment of retinoblastoma, gains access to the vitreous when…”
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Morphine withdrawal syndrome and its prevention with baclofen: Autoradiographic study of μ-opioid receptors in prepubertal male and female mice by Diaz, Silvina L., Barros, Virginia G., Antonelli, Marta C., Rubio, Modesto C., Balerio, Graciela N.

“…Although the expression of the morphine (MOR) withdrawal syndrome is more marked in male mice than in females, we have demonstrated that the GABAB agonist…”
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Cytoskeleton of hippocampal neurons as a target for valproic acid in an experimental model of depression by Ferrero, Alejandro J., Cereseto, Marina, Sifonios, Laura L., Reinés, Analía, Peixoto, Estanislao, Rubio, Modesto C., Wikinski, Silvia

“…Atrophy of pyramidal hippocampal neurons and of the entire hippocampus has been reported in experimental models of depression and in depressive patients…”
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Morphine withdrawal syndrome: Involvement of the dopaminergic system in prepubertal male and female mice by Diaz, Silvina L., Kemmling, Alma K., Rubio, Modesto C., Balerio, Graciela N.

“…Morphine (MOR) withdrawal signs are more marked in males than in females. Considering that the influence of the dopaminergic system on these differences is…”
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BACLOFEN ANALGESIA: INVOLVEMENT OF THE GABAergic SYSTEM by BALERIO, GRACIELA N., RUBIO, MODESTO C.

“…The effect of baclofen, a GABA B agonist, has been studied in the hot plate test in mice, to analyze the possible involvement of the GABAergic system in…”
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Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release by Ferrero, Alejandro J., Cereseto, Marina, Reinés, Analía, Bonavita, Carla D., Sifonios, Laura L., Rubio, Modesto C., Wikinski, Silvia I.

“…The proconvulsive effect of the new generation of antidepressants remains controversial. The authors investigated in naïve rats the effect of chronic treatment…”
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Pharmacokinetic study of the variability of indinavir drug levels when boosted with ritonavir in HIV-infected children by Curras, Verónica, Hocht, Christian, Mangano, Andrea, Niselman, Viviana, Mariño Hernández, Eduardo, Cáceres Guido, Paulo, Mecikovsky, Débora, Bellusci, Carolina, Bologna, Rosa, Sen, Luisa, Rubio, Modesto C, Bramuglia, Guillermo F

“…The aim of this work is to: (1) assess therapeutic drug monitoring of indinavir (IDV) during clinical routine practice in HIV-infected children, whose…”
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P-glycoprotein functional activity in peripheral blood lymphocytes in ulcerative colitis by Cortada, Catalina M, Gil, Anibal, Goncalves, Silvina, Sambuelli, Alicia, Rubio, Modesto C, Carballo, Marta A

“…P-glycoprotein (P-gp), encoded by MDR-1, is a transmembrane efflux pump that has been involved in relevant clinical drug transport. It is expressed in…”
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Lymphocyte P-glycoprotein variability in healthy individuals by Cortada, Catalina M, Escobar, Anahi, Bramuglia, Guillermo F, Niselman, A Viviana, Carballo, Marta A, Rubio, Modesto C

“…The aim of the present work was to describe the distribution of lymphocyte P-glycoprotein activity on a population of healthy individuals, taking also into…”
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Diazepam fails to potentiate GABA-induced chloride uptake and to produce anxiolytic-like action in aged rats by Wikinski, Silvia I, Acosta, Gabriela B, Gravielle, Marı́a Clara, Bonavita, Carla D, Bisagno, Verónica, Fiszer de Plazas, Sara, Rubio, Modesto C

“…The pharmacological response to benzodiazepines has been demonstrated to be different in aged individuals in comparison to adults. We studied the age-dependent…”
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Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of baclofen in mice by Balerio, Graciela N, Rubio, Modesto C

“…The aim of this study was the development of a pharmacokinetic-pharmacodynamic (PK/PD) model of the antinociceptive effect of baclofen in mice. We studied the…”
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Lack of tolerance to the anxiolytic effect of diazepam and pentobarbital following chronic administration in perinatally undernourished rats by Borghese, Cecilia M, Córdoba, Nancy E, Laino, Carlos H, Orsingher, Otto A, Rubio, Modesto C, Niselman, Viviana

“…Adult female rats, undernourished at perinatal age, were evaluated for anxiolytic action in the plus-maze test after acute and chronic administration of…”
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Involvement of monoamine oxidase and noradrenaline uptake in the positive chronotropic effects of apigenin in rat atria by Lorenzo, Patricia S., Rubio, Modesto C., Medina, Jorge H., Adler-Graschinsky, Edda

“…In rat isolated atria spontaneously beating and labelled with [ 3H]noradrenaline, exposure to the flavonoid apigenin increased the atrial rate in a…”
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Tetronic.sup.[R] 904-containing polymeric micelles overcome the overexpression of ABCG2 in the blood-brain barrier of rats and boost the penetration of the antiretroviral efavirenz into the CNS by Roma, Martín I, Hocht, Christian, Chiappetta, Diego A, Di Gennaro, Stefania S, Minoia, Juan M, Bramuglia, Guillermo F, Rubio, Modesto C, Sosnik, Alejandro, Peroni, Roxana N

“…Aim: To assess the involvement of ABCG2 in the pharmacokinetics of efavirenz in the blood-brain barrier (BBB) and investigate a nanotechnology strategy to…”
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Tetronic by Roma, Martín I, Hocht, Christian, Chiappetta, Diego A, Di Gennaro, Stefania S, Minoia, Juan M, Bramuglia, Guillermo F, Rubio, Modesto C, Sosnik, Alejandro, Peroni, Roxana N

“…To assess the involvement of ABCG2 in the pharmacokinetics of efavirenz in the blood-brain barrier (BBB) and investigate a nanotechnology strategy to overcome…”
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