Search Results - "Rubinstein, Natalia"

Structural and functional comparison of SARS-CoV-2-spike receptor binding domain produced in Pichia pastoris and mammalian cells by Arbeitman, Claudia R., Auge, Gabriela, Blaustein, Matías, Bredeston, Luis, Corapi, Enrique S., Craig, Patricio O., Cossio, Leandro A., Dain, Liliana, D’Alessio, Cecilia, Elias, Fernanda, Fernández, Natalia B., Gándola, Yamila B., Gasulla, Javier, Gorojovsky, Natalia, Gudesblat, Gustavo E., Herrera, María G., Ibañez, Lorena I., Idrovo, Tommy, Rando, Matías Iglesias, Kamenetzky, Laura, Nadra, Alejandro D., Noseda, Diego G., Paván, Carlos H., Pavan, María F., Pignataro, María F., Roman, Ernesto, Ruberto, Lucas A. M., Rubinstein, Natalia, Santos, Javier, Velazquez, Francisco, Zelada, Alicia M.

“…The yeast Pichia pastoris is a cost-effective and easily scalable system for recombinant protein production. In this work we compared the conformation of the…”
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A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer by Saxena, Meera, Kalathur, Ravi K R, Rubinstein, Natalia, Vettiger, Andrea, Sugiyama, Nami, Neutzner, Melanie, Coto-Llerena, Mairene, Kancherla, Venkatesh, Ercan, Caner, Piscuoglio, Salvatore, Fischer, Jonas, Fagiani, Ernesta, Cantù, Claudio, Basler, Konrad, Christofori, Gerhard

“…Pygopus 2 (Pygo2) is a coactivator of Wnt/β-catenin signaling that can bind bi- or trimethylated lysine 4 of histone-3 (H3K4me ) and participate in chromatin…”
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Angiotensin-(1-7) counteracts the transforming effects triggered by angiotensin II in breast cancer cells by Cambados, Nadia, Walther, Thomas, Nahmod, Karen, Tocci, Johanna M, Rubinstein, Natalia, Böhme, Ilka, Simian, Marina, Sampayo, Rocío, Del Valle Suberbordes, Melisa, Kordon, Edith C, Schere-Levy, Carolina

“…Angiotensin (Ang) II, the main effector peptide of the renin-angiotensin system, has been implicated in multiple aspects of cancer progression such as…”
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RUNX1 Is Regulated by Androgen Receptor to Promote Cancer Stem Markers and Chemotherapy Resistance in Triple Negative Breast Cancer by Fernández, Natalia B, Sosa, Sofía M, Roberts, Justin T, Recouvreux, María S, Rocha-Viegas, Luciana, Christenson, Jessica L, Spoelstra, Nicole S, Couto, Facundo L, Raimondi, Ana R, Richer, Jennifer K, Rubinstein, Natalia

“…Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype for which no effective targeted therapies are available. Growing evidence suggests…”
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Unlocking the secrets of galectins: a challenge at the frontier of glyco-immunology by Rabinovich, Gabriel A., Rubinstein, Natalia, Fainboim, Leonardo

“…Over the last decade, we have witnessed an explosion of information regarding the function of glycoconjugates, carbohydrate‐binding proteins, and the…”
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The interactions of Bcl9/Bcl9L with [beta]-catenin and Pygopus promote breast cancer growth, invasion, and metastasis by Vafaizadeh, Vida, Buechel, David, Rubinstein, Natalia, Kalathur, Ravi K. R, Bazzani, Lorenzo, Saxena, Meera, Valenta, Tomas

“…Canonical Wnt/[beta]-catenin signaling is an established regulator of cellular state and its critical contributions to tumor initiation, malignant tumor…”
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Parsing β-catenin’s cell adhesion and Wnt signaling functions in malignant mammary tumor progression by Buechel, David, Sugiyama, Nami, Rubinstein, Natalia, Saxena, Meera, Kalathur, Ravi K. R., Lüönd, Fabiana, Vafaizadeh, Vida, Valenta, Tomas, Hausmann, George, Cantù, Claudio, Basler, Konrad, Christofori, Gerhard

“…During malignant progression, epithelial cancer cells dissolve their cell–cell adhesion and gain invasive features. By virtue of its dual function, β-catenin…”
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Mechanical strain induces involution-associated events in mammary epithelial cells by Quaglino, Ana, Salierno, Marcelo, Pellegrotti, Jesica, Rubinstein, Natalia, Kordon, Edith C

“…Shortly after weaning, a complex multi-step process that leads to massive epithelial apoptosis is triggered by tissue local factors in the mouse mammary gland…”
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The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis by Vafaizadeh, Vida, Buechel, David, Rubinstein, Natalia, Kalathur, Ravi K. R., Bazzani, Lorenzo, Saxena, Meera, Valenta, Tomas, Hausmann, George, Cantù, Claudio, Basler, Konrad, Christofori, Gerhard

“…Canonical Wnt/β-catenin signaling is an established regulator of cellular state and its critical contributions to tumor initiation, malignant tumor progression…”
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Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma by Croci, Diego O, Salatino, Mariana, Rubinstein, Natalia, Cerliani, Juan P, Cavallin, Lucas E, Leung, Howard J, Ouyang, Jing, Ilarregui, Juan M, Toscano, Marta A, Domaica, Carolina I, Croci, María C, Shipp, Margaret A, Mesri, Enrique A, Albini, Adriana, Rabinovich, Gabriel A

“…Kaposi's sarcoma (KS), a multifocal vascular neoplasm linked to human herpesvirus-8 (HHV-8/KS-associated herpesvirus [KSHV]) infection, is the most common…”
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Covalent coupling of Spike’s receptor binding domain to a multimeric carrier produces a high immune response against SARS-CoV-2 by Berguer, Paula M., Blaustein, Matías, Bredeston, Luis M., Craig, Patricio O., D’Alessio, Cecilia, Elias, Fernanda, Farré, Paola C., Fernández, Natalia B., Gentili, Hernán G., Gándola, Yamila B., Gasulla, Javier, Gudesblat, Gustavo E., Herrera, María G., Ibañez, Lorena I., Idrovo-Hidalgo, Tommy, Nadra, Alejandro D., Noseda, Diego G., Paván, Carlos H., Pavan, María F., Pignataro, María F., Roman, Ernesto A., Ruberto, Lucas A. M., Rubinstein, Natalia, Sanchez, María V., Santos, Javier, Wetzler, Diana E., Zelada, Alicia M.

“…The receptor binding domain (RBD) of the Spike protein from SARS-CoV-2 is a promising candidate to develop effective COVID-19 vaccines since it can induce…”
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Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: A potential mechanism of tumor-immune privilege by Rubinstein, Natalia, Alvarez, Mariano, Zwirner, Norberto W, Toscano, Marta A, Ilarregui, Juan M, Bravo, Alicia, Mordoh, José, Fainboim, Leonardo, Podhajcer, Osvaldo L, Rabinovich, Gabriel A

“…Despite the existence of tumor-specific immune cells, most tumors have devised strategies to avoid immune attack. We demonstrate here that galectin-1 (Gal-1),…”
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R-spondin3 Is Associated with Basal-Progenitor Behavior in Normal and Tumor Mammary Cells by Tocci, Johanna M, Felcher, Carla M, García Solá, Martín E, Goddio, María Victoria, Zimberlin, María Noel, Rubinstein, Natalia, Srebrow, Anabella, Coso, Omar A, Abba, Martín C, Meiss, Roberto P, Kordon, Edith C

“…R-spondin3 (RSPO3) is a member of a family of secreted proteins that enhance Wnt signaling pathways in diverse processes, including cancer. However, the role…”
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RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes by Recouvreux, María Sol, Grasso, Esteban Nicolás, Echeverria, Pablo Christian, Rocha-Viegas, Luciana, Castilla, Lucio Hernán, Schere-Levy, Carolina, Tocci, Johanna Melisa, Kordon, Edith Claudia, Rubinstein, Natalia

“…Runx1 participation in epithelial mammary cells is still under review. Emerging data indicates that Runx1 could be relevant for breast tumor promotion…”
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Author Correction: Covalent coupling of Spike’s receptor binding domain to a multimeric carrier produces a high immune response against SARS-CoV-2 by Berguer, Paula M., Blaustein, Matías, Bredeston, Luis M., Craig, Patricio O., D’Alessio, Cecilia, Elias, Fernanda, Farré, Paola C., Fernández, Natalia B., Gentili, Hernán G., Gándola, Yamila B., Gasulla, Javier, Gudesblat, Gustavo E., Herrera, María G., Ibañez, Lorena I., Idrovo-Hidalgo, Tommy, Nadra, Alejandro D., Noseda, Diego G., Paván, Carlos H., Pavan, María F., Pignataro, María F., Roman, Ernesto A., Ruberto, Lucas A. M., Rubinstein, Natalia, Sanchez, María V., Santos, Javier, Wetzler, Diana E., Zelada, Alicia M.

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Galectin-1 suppresses experimental colitis in mice by Santucci, Luca, Fiorucci, Stefano, Rubinstein, Natalia, Mencarelli, Andrea, Palazzetti, Barbara, Federici, Barbara, Rabinovich, Gabriel A., Morelli, Antonio

“…Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to…”
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Role of galectins in inflammatory and immunomodulatory processes by Rabinovich, Gabriel A, Rubinstein, Natalia, Toscano, Marta A

“…Galectins are members of a highly conserved family of β-galactoside-binding animal lectins. Presently, more than 14 members have been identified and additional…”
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Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss by Ramhorst, Rosanna E, Giribaldi, Laura, Fraccaroli, Laura, Toscano, Marta A, Stupirski, Juan C, Romero, Marta D, Durand, Edith S, Rubinstein, Natalia, Blaschitz, Astrid, Sedlmayr, Peter, Genti-Raimondi, Susana, Fainboim, Leonardo, Rabinovich, Gabriel A

“…Mechanisms accounting for the protection of the fetal semi-allograft from maternal immune cells remain incompletely understood. In previous studies, we showed…”
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Regulation of galectin-1 expression by transforming growth factor β1 in metastatic mammary adenocarcinoma cells: implications for tumor-immune escape by Daroqui, Cecilia M., Ilarregui, Juan M., Rubinstein, Natalia, Salatino, Mariana, Toscano, Marta A., Vazquez, Paula, Bakin, Andrei, Puricelli, Lydia, Bal de Kier Joffé, Elisa, Rabinovich, Gabriel A.

“…Tumors escape from immune surveillance by producing immunosuppressive cytokines and proapototic factors, including TGF-β and galectin-1 (Gal-1). Since…”
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Abstract B13: R-spondin3 overexpression induces transformation and deregulates expression of genes controlling cell proliferation and apoptosis in NIH3T3 cells by Zimberlin, Maria Noel, Rubinstein, Natalia, Coso, Omar A., Kordon, Edith C.

“…Abstract It has been reported that R-spondin3 (Rspo3) is a common insertion site for the viral genome in mouse mammary tumor virus (MMTV) induced-mammary…”
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