Search Results - "Rubinstein, Amir"
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1
Computational thinking in life science education
Published in PLoS computational biology (01-11-2014)“…We join the increasing call to take computational education of life science students a step further, beyond teaching mere programming and employing existing…”
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Journal Article -
2
Catalyzing Racemizations in the Absence of a Cofactor: The Reaction Mechanism in Proline Racemase
Published in Journal of the American Chemical Society (24-06-2009)“…The origin of the catalytic proficiency of the cofactor-independent enzyme proline racemase (ProR) has been investigated by a combined classical and quantum…”
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Journal Article -
3
Interactions between the circadian clock and TGF-β signaling pathway in zebrafish
Published in PloS one (25-06-2018)“…TGF-β signaling is a cellular pathway that functions in most cells and has been shown to play a role in multiple processes, such as the immune response, cell…”
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Journal Article -
4
Understanding Catalytic Specificity in Alanine Racemase from Quantum Mechanical and Molecular Mechanical Simulations of the Arginine 219 Mutant
Published in Biochemistry (Easton) (11-05-2010)“…Alanine racemase (AlaR) catalyzes the interconversion between l-Ala and d-Ala with the aid of the cofactor pyridoxal 5′-phosphate (PLP). The pyridine nitrogen…”
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Simulation and visualization of multiple KEGG pathways using BioNSi [version 2; peer review: 2 approved, 1 approved with reservations]
Published in F1000 research (01-01-2017)“…Motivation: Many biologists are discouraged from using network simulation tools because these require manual, often tedious network construction. This…”
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Journal Article -
6
Faithful modeling of transient expression and its application to elucidating negative feedback regulation
Published in Proceedings of the National Academy of Sciences - PNAS (10-04-2007)“…Modeling and analysis of genetic regulatory networks is essential both for better understanding their dynamic behavior and for elucidating and refining open…”
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Work in progress - Courses dedicated to the development of logical and algorithmic thinking
Published in 2011 Frontiers in Education Conference (FIE) (01-10-2011)“…Undergraduate students often start their academic course of studies with inadequate learning and thinking skills. Our college has a policy of setting high…”
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Conference Proceeding -
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A Computational Approach to Study Gene Expression Networks
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2017)“…We describe a simple computational approach that can be used for the study and simulation of regulatory networks. The advantage of this approach is that it…”
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Journal Article -
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Computational Thinking in Life Science Education: e1003897
Published in PLoS computational biology (01-11-2014)“…We join the increasing call to take computational education of life science students a step further, beyond teaching mere programming and employing existing…”
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Journal Article -
10
Computer science for non-technological cyber programs
Published in 2014 IEEE Frontiers in Education Conference (FIE) Proceedings (01-10-2014)“…The world of cyberspace revolves around the scientific and technological as well as other facets of the internet, data encryption, digital communication,…”
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Conference Proceeding -
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Aerobic Carbon–Carbon Bond Cleavage of Alkenes to Aldehydes Catalyzed by First-Row Transition-Metal-Substituted Polyoxometalates in the Presence of Nitrogen Dioxide
Published in Journal of the American Chemical Society (06-08-2014)“…A new aerobic carbon–carbon bond cleavage reaction of linear di-substituted alkenes, to yield the corresponding aldehydes/ketones in high selectivity under…”
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Journal Article -
12
Interactions between the circadian clock and TGF-[beta] signaling pathway in zebrafish
Published in PloS one (25-06-2018)“…Background TGF-[beta] signaling is a cellular pathway that functions in most cells and has been shown to play a role in multiple processes, such as the immune…”
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Journal Article -
13
BioNSi: A Discrete Biological Network Simulator Tool
Published in Journal of proteome research (05-08-2016)“…Modeling and simulation of biological networks is an effective and widely used research methodology. The Biological Network Simulator (BioNSi) is a tool for…”
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Journal Article -
14
Molecular dynamics simulations of the intramolecular proton transfer and carbanion stabilization in the pyridoxal 5′-phosphate dependent enzymes l-dopa decarboxylase and alanine racemase
Published in Biochimica et biophysica acta (01-11-2011)“…Molecular dynamics simulations using a combined quantum mechanical and molecular mechanical (QM/MM) potential have been carried out to investigate the internal…”
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Journal Article -
15
Simulation and visualization of multiple KEGG pathways using BioNSi [version 1; peer review: 1 approved with reservations, 1 not approved]
Published in F1000 research (2017)“…Motivation: Many biologists are discouraged from using network simulation tools because these require manual, often tedious network construction. This…”
Get full text
Journal Article -
16
The effective application of a discrete transition model to explore cell-cycle regulation in yeast
Published in BMC research notes (06-08-2013)“…Bench biologists often do not take part in the development of computational models for their systems, and therefore, they frequently employ them as…”
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Journal Article -
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The Combination of Nitrogen and Sulfur Oxide Compounds with Transition Metal Substituted Polyoxometalates as a Platform for Novel Catalytic Aerobic Oxidations of Alkenes
Published 01-01-2014“…Catalytic oxidation of organic compounds is one of the most industrially important processes. Specifically, our group has a long-standing interest in such…”
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Dissertation