Search Results - "Rubin, Steven A"

Recent Mumps Outbreaks in Vaccinated Populations: No Evidence of Immune Escape by RUBIN, Steven A, LINK, Malen A, SAUDER, Christian J, ZHANG, Cheryl, NGO, Laurie, RIMA, Bert K, DUPREX, W. Paul

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Antibody Induced by Immunization with the Jeryl Lynn Mumps Vaccine Strain Effectively Neutralizes a Heterologous Wild-Type Mumps Virus Associated with a Large Outbreak by Rubin, Steven A., Qi, Li, Audet, Susette A., Sullivan, Bradley, Carbone, Kathryn M., Bellini, William J., Rota, Paul A., Sirota, Lev, Beeler, Judy

“…Recent mumps outbreaks in older vaccinated populations were caused primarily by genotype G viruses, which are phylogenetically distinct from the genotype A…”
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Gene-Specific Contributions to Mumps Virus Neurovirulence and Neuroattenuation by SAUDER, Christian J, ZHANG, Cheryl X, NGO, Laurie, WERNER, Kellie, LEMON, Ken, DUPREX, W. Paul, MALIK, Tahir, CARBONE, Kathryn, RUBIN, Steven A

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Generation and propagation of recombinant mumps viruses exhibiting an additional U residue in the homopolymeric U tract of the F gene-end signal by Sauder, Christian J., Ngo, Laurie, Simonyan, Vahan, Cong, Yu, Zhang, Cheryl, Link, Malen, Malik, Tahir, Rubin, Steven A.

“…As a member of the family paramyxoviridae, subfamily paramyxovirinae, the genome of mumps virus (MuV) is postulated to be polyhexameric in length in order to…”
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Activation of Microglia by Borna Disease Virus Infection: In Vitro Study by OVANESOV, Mikhail V, SAUDER, Christian, RUBIN, Steven A, RICHT, Jurgen, NATH, Avindra, CARBONE, Kathryn M, PLETNIKOV, Mikhail V

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The Rat-Based Neurovirulence Safety Test for the Assessment of Mumps Virus Neurovirulence in Humans: An International Collaborative Study by Rubin, Steven A., Afzal, Muhammad A., Powell, Caroline L., Bentley, Maureen L., Auda, Ghazi R., Taffs, Rolf E., Carbone, Kathryn M.

“…Because of the highly neurotropic and neurovirulent properties of wild-type mumps viruses, most national regulatory organizations require neurovirulence…”
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Changes in Mumps Virus Gene Sequence Associated with Variability in Neurovirulent Phenotype by Rubin, Steven A, Amexis, Georgios, Pletnikov, Mikhail, Li, Zongqi, Vanderzanden, Jacqueline, Mauldin, Jeremy, Sauder, Christian, Malik, Tahir, Chumakov, Konstantin, Carbone, Kathryn M

“…Author's Correction ( vol. 81 , p. 8849 ) Erratum ( vol. 77 , p. 13455 ) Erratum ( vol. 77 , p. 13456 ) Article Usage Stats Services JVI Citing Articles Google…”
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Enhanced Neurovirulence of Borna Disease Virus Variants Associated with Nucleotide Changes in the Glycoprotein and L Polymerase Genes by Nishino, Yoshii, Kobasa, Darwyn, Rubin, Steven A, Pletnikov, Mikhail V, Carbone, Kathryn M

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Evidence that a polyhexameric genome length is preferred, but not strictly required, for efficient mumps virus replication by Sauder, Christian J, Simonyan, Vahan, Ngo, Laurie, Karagiannis, Konstantinos, Cong, Yu, Zhang, Cheryl, Wang, Rong, Wu, Wells W, Malik, Tahir, Rubin, Steven A

“…Abstract Mumps virus (MuV) is postulated to adhere to the “rule of six” for efficient replication. To examine the requirement for MuV, minigenomes of…”
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Persistent Neonatal Borna Disease Virus (BDV) Infection of the Brain Causes Chronic Emotional Abnormalities in Adult Rats by Pletnikov, Mikhail V, Rubin, Steven A, Schwartz, Gary J, Moran, Timothy H, Sobotka, Thomas J, Carbone, Kathryn M

“…Neonatal Borna disease virus (BDV) brain infection results in selective developmental damage to the hippocampal dentate gyrus and the cerebellum. When mature,…”
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Toward replacement of the monkey neurovirulence test in vaccine safety testing by Rubin, Steven A

“…For live, attenuated vaccines derived from neurotropic wild-type viruses, regulatory authorities require neurovirulence safety testing, typically using…”
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The Mumps Virus Neurovirulence Safety Test in Rhesus Monkeys: A Comparison of Mumps Virus Strains by Rubin, Steven A., Snoy, Philip J., Wright, Kathryn E., Brown, Earl G., Reeve, Peter, Beeler, Judy A., Carbone, Kathryn M.

“…Wild type mumps viruses are highly neurotropic and a frequent cause of aseptic meningitis in unvaccinated humans. To test whether attenuated mumps viruses used…”
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Functional consequences of attenuating mutations in the haemagglutinin neuraminidase, fusion and polymerase proteins of a wild-type mumps virus strain by Malik, Tahir, Wolbert, Candie, Mauldin, Jeremy, Sauder, Christian, Carbone, Kathryn M, Rubin, Steven A

“…1 DVP/Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA 2 Department…”
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Changes in mumps virus neurovirulence phenotype associated with quasispecies heterogeneity by Sauder, Christian J., Vandenburgh, Kari M., Iskow, Rebecca C., Malik, Tahir, Carbone, Kathryn M., Rubin, Steven A.

“…Mumps virus is a highly neurotropic virus with evidence of central nervous system invasion (CNS) in approximately half of all cases of infection. In countries…”
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Presence of lysine at aa 335 of the hemagglutinin-neuraminidase protein of mumps virus vaccine strain Urabe AM9 is not a requirement for neurovirulence by Sauder, Christian J, Zhang, Cheryl X, Link, Malen A, Duprex, W. Paul, Carbone, Kathryn M, Rubin, Steven A

“…Abstract The recent global resurgence of mumps has drawn attention to the continued need for robust mumps immunization programs. Unfortunately, some vaccines…”
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Identification of genetic mutations associated with attenuation and changes in tropism of Urabe mumps virus by Shah, Dion, Vidal, Silvia, Link, Malen A, Rubin, Steven A, Wright, Kathryn E

“…Although several effective mumps virus vaccines have been developed, almost nothing is known about the genetic changes responsible for loss of virulence. One…”
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A mouse-based assay for the pre-clinical neurovirulence assessment of vaccinia virus-based smallpox vaccines by Zhang, Cheryl X., Sauder, Christian, Malik, Tahir, Rubin, Steven A.

“…Post-vaccinal encephalitis, although relatively uncommon, is a known adverse event associated with many live, attenuated smallpox vaccines. Although smallpox…”
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Peripheral Expression of Self-MHC-II Influences the Reactivity and Self-Tolerance of Mature CD4 + T Cells : Evidence from a Lymphopenic T Cell Model by Bhandoola, Avinash, Tai, Xuguang, Eckhaus, Michael, Auchincloss, Hugh, Mason, Karen, Rubin, Steven A, Carbone, Kathryn M, Grossman, Zvi, Rosenberg, Amy S, Singer, Alfred

“…While intrathymic MHC expression influences the specificity of developing thymocytes, we considered that peripheral MHC expression might influence the…”
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Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism by Pletnikov, Mikhail V, A. Rubin, Steven, Vasudevan, Kuzhalini, Moran, Timothy H, M. Carbone, Kathryn

“…Play behavior, nonsocial exploratory activity, and nonplay social interaction were observed in male juvenile Lewis rats with brain developmental injury…”
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Mouse neurotoxicity test for vaccinia-based smallpox vaccines by Li, Zhongqi, Rubin, Steven A, Taffs, Rolf E, Merchlinsky, Michael, Ye, Zhiping, Carbone, Kathryn M

“…The only US FDA licensed smallpox vaccine, Dryvax, was associated with rare but serious neurological adverse events. After smallpox was eradicated in the…”
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