Search Results - "Rubin, P"

Therapeutic targeting of TEAD transcription factors in cancer by Pobbati, Ajaybabu V., Kumar, Ramesh, Rubin, Brian P., Hong, Wanjin

“…TEAD transcription factors pair with YAP and TAZ to orchestrate various transcriptional programs of cell proliferation and cell death suppression that promote…”
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Protein-Protein Interaction Disruptors of the YAP/TAZ-TEAD Transcriptional Complex by Pobbati, Ajaybabu V, Rubin, Brian P

“…The identification of protein-protein interaction disruptors (PPIDs) that disrupt the YAP/TAZ-TEAD interaction has gained considerable momentum. Several…”
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Sox10 : A Pan-Schwannian and Melanocytic Marker by NONAKA, Daisuke, CHIRIBOGA, Luis, RUBIN, Brian P

“…S100 protein is a sensitive marker for melanomas and peripheral nerve sheath tumors. It is, however, expressed by other mesenchymal and epithelial tumors…”
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Symptom Signatures and Diagnostic Timeliness in Cancer Patients: A Review of Current Evidence by Koo, Minjoung M., Hamilton, William, Walter, Fiona M., Rubin, Greg P., Lyratzopoulos, Georgios

“…Early diagnosis is an important aspect of contemporary cancer prevention and control strategies, as the majority of patients are diagnosed following…”
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Functional Enhancers Shape Extrachromosomal Oncogene Amplifications by Morton, Andrew R., Dogan-Artun, Nergiz, Faber, Zachary J., MacLeod, Graham, Bartels, Cynthia F., Piazza, Megan S., Allan, Kevin C., Mack, Stephen C., Wang, Xiuxing, Gimple, Ryan C., Wu, Qiulian, Rubin, Brian P., Shetty, Shashirekha, Angers, Stephane, Dirks, Peter B., Sallari, Richard C., Lupien, Mathieu, Rich, Jeremy N., Scacheri, Peter C.

“…Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant…”
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Measures of promptness of cancer diagnosis in primary care: secondary analysis of national audit data on patients with 18 common and rarer cancers by Lyratzopoulos, G, Abel, G A, McPhail, S, Neal, R D, Rubin, G P

“…Background: Evidence is needed about the promptness of cancer diagnosis and associations between its measures. Methods: We analysed data from the National…”
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Alpha to Omicron: Disease Severity and Clinical Outcomes of Major SARS-CoV-2 Variants by Esper, Frank P, Adhikari, Thamali M, Tu, Zheng Jin, Cheng, Yu-Wei, El-Haddad, Kim, Farkas, Daniel H, Bosler, David, Rhoads, Daniel, Procop, Gary W, Ko, Jennifer S, Jehi, Lara, Li, Jing, Rubin, Brian P

“…Four severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants predominated in the United States since 2021. Understanding disease severity related…”
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A novel and fully automated platform for synthetic tabular data generation and validation by Rashidi, Hooman H., Albahra, Samer, Rubin, Brian P., Hu, Bo

“…Healthcare data accessibility for machine learning (ML) is encumbered by a range of stringent regulations and limitations. Using synthetic data that mirrors…”
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Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms by Gong, Xiaoming, Smith, Joshua R, Swanson, Haley M, Rubin, Lewis P

“…Increasing evidence suggests that dietary carotenoids may reduce the risk of breast cancer. However, anti-breast cancer effects of carotenoids have been…”
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The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas by Fang, Dong, Gan, Haiyun, Lee, Jeong-Heon, Han, Jing, Wang, Zhiquan, Riester, Scott M., Jin, Long, Chen, Jianji, Zhou, Hui, Wang, Jinglong, Zhang, Honglian, Yang, Na, Bradley, Elizabeth W., Ho, Thai H., Rubin, Brian P., Bridge, Julia A., Thibodeau, Stephen N., Ordog, Tamas, Chen, Yue, van Wijnen, Andre J., Oliveira, Andre M., Xu, Rui-Ming, Westendorf, Jennifer J., Zhang, Zhiguo

“…More than 90% of chondroblastomas contain a heterozygous mutation replacing lysine-36 with methionine-36 (K36M) in the histone H3 variant H3.3. Here we show…”
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Self-Reported bruxism and associated factors in Israeli adolescents by Emodi Perlman, A., Lobbezoo, F., Zar, A., Friedman Rubin, P., van Selms, M. K. A., Winocur, E.

“…Summary Little is known about the epidemiological characteristics of sleep and awake bruxism (SB and AB) in adolescents. The aims of the study were: to assess…”
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Variation in number of general practitioner consultations before hospital referral for cancer: findings from the 2010 National Cancer Patient Experience Survey in England by Lyratzopoulos, Georgios, Dr, Neal, Richard D, PhD, Barbiere, Josephine M, MPH, Rubin, Gregory P, Prof, Abel, Gary A, PhD

“…Summary Background Information from patient surveys can help to identify patient groups and cancers with the greatest potential for improvement in the…”
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Identification of recurrent SMO and BRAF mutations in ameloblastomas by Sweeney, Robert T, McClary, Andrew C, Myers, Benjamin R, Biscocho, Jewison, Neahring, Lila, Kwei, Kevin A, Qu, Kunbin, Gong, Xue, Ng, Tony, Jones, Carol D, Varma, Sushama, Odegaard, Justin I, Sugiyama, Toshihiro, Koyota, Souichi, Rubin, Brian P, Troxell, Megan L, Pelham, Robert J, Zehnder, James L, Beachy, Philip A, Pollack, Jonathan R, West, Robert B

“…Robert West, Jonathan Pollack and colleagues identify mutations in either the Hedgehog pathway gene SMO or the MAPK gene BRAF in 24 of the 28 ameloblastoma…”
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Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein by Tanas, M R, Ma, S, Jadaan, F O, Ng, C K Y, Weigelt, B, Reis-Filho, J S, Rubin, B P

“…The WWTR1 (protein is known as TAZ) -CAMTA1 ( WC ) fusion gene defines epithelioid hemangioendothelioma, a malignant vascular cancer. TAZ ( t ranscriptional co…”
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Inhibition of PI3K and MAPK pathways along with KIT inhibitors as a strategy to overcome drug resistance in gastrointestinal stromal tumors by Gupta, Anu, Ma, Shuang, Che, Kepeng, Pobbati, Ajaybabu V, Rubin, Brian P

“…Activating mutations in KIT/PDGFRA receptor tyrosine kinases drive gastrointestinal stromal tumors (GIST). KIT/PDGFRA inhibitors, such as imatinib do not evoke…”
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Gastrointestinal stromal tumour by Rubin, Brian P, MD, Heinrich, Michael C, Prof, Corless, Christopher L, Prof

“…Summary Gastrointestinal stromal tumours are the most common mesenchymal neoplasm of the gastrointestinal tract and are highly resistant to conventional…”
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Imatinib Mesylate in Advanced Dermatofibrosarcoma Protuberans: Pooled Analysis of Two Phase II Clinical Trials by Rutkowski, Piotr, Van Glabbeke, Martine, Rankin, Cathryn J, Ruka, Wlodzimierz, Rubin, Brian P, Debiec-Rychter, Maria, Lazar, Alexander, Gelderblom, Hans, Sciot, Raf, Lopez-Terrada, Dolores, Hohenberger, Peter, van Oosterom, Allan T, Schuetze, Scott M

“…Dermatofibrosarcoma protuberans (DFSP) is a dermal sarcoma typically carrying a translocation between chromosomes 17 and 22 that generates functional…”
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Leveraging Hot Spots of TEAD-Coregulator Interactions in the Design of Direct Small Molecule Protein-Protein Interaction Disruptors Targeting Hippo Pathway Signaling by Zhao, Bin, Pobbati, Ajaybabu V, Rubin, Brian P, Stauffer, Shaun

“…The Hippo signaling pathway is a highly conserved pathway that plays important roles in the regulation of cell proliferation and apoptosis. Transcription…”
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Gastrointestinal stromal tumours: an update by Rubin, B P

“…Recently, there has been intense interest in the study of gastrointestinal stromal tumour (GIST); one might call it a virtual GIST revolution. This is due…”
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Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival by Cleven, Arjen H G, Sannaa, Ghadah A Al, Briaire-de Bruijn, Inge, Ingram, Davis R, van de Rijn, Matt, Rubin, Brian P, de Vries, Maurits W, Watson, Kelsey L, Torres, Kelia E, Wang, Wei-Lien, van Duinen, Sjoerd G, Hogendoorn, Pancras C W, Lazar, Alexander J, Bovée, Judith V M G

“…Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that can show overlapping features with benign neurofibromas as well as high-grade…”
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