Search Results - "Rubin, L R"

Drug-induced lupus by Rubin, Robert L.

“…Autoantibodies and, less commonly, systemic rheumatic symptoms are associated with treatment with numerous medications and other types of ingested compounds…”
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Comparison of Patients' Ethical Perspectives of Preimplantation Embryo Genetic Testing for Aneuploidy (PGT-A) vs. Monogenic Disorders (PGT-M) by Zhang, J, Rubin, L R, Zierhut, H, Pastore, L M

“…What are the ethical perspectives of preimplantation genetic testing in patients using/considering PGT-A compared to those using/considering PGT-M? A 17-item…”
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Severe hydralazine-induced lupus presenting as systemic lupus erythematosus by Rubin, R L, Haluptzok, R F, Davila, L M

“…Despite its long history of untoward side effects of a systemic autoimmune disease, drug-induced lupus can be difficult to recognize because of the disconnect…”
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Review of patient decision‐making factors and attitudes regarding preimplantation genetic diagnosis by Genoff Garzon, M.C., Rubin, L.R., Lobel, M., Stelling, J., Pastore, L.M.

“…The increasing technical complexity and evolving options for repro‐genetic testing have direct implications for information processing and decision making, yet…”
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Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen by BURLINGAME, R. W, RUBIN, R. L, BALDERAS, R. S, THEOFILOPOULOS, A. N

“…Autoantibodies reacting with chromatin and its components, histones and DNA, are characteristic of the human autoimmune disease SLE and drug-induced lupus, but…”
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Transformation of Lupus-Inducing Drugs to Cytotoxic Products by Activated Neutrophils by Jiang, Xiaoxia, Khursigara, Gus, Rubin, Robert L.

“…Drug-induced lupus is a serious side effect of certain medications, but the chemical features that confer this property and the underlying pathogenesis are…”
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The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus by Burlingame, R W, Boey, M L, Starkebaum, G, Rubin, R L

“…To gain insight into the mechanisms of autoantibody induction, sera from 40 patients with systemic lupus erythematosus (SLE) were tested by ELISAs for antibody…”
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Binding to histone of an anomalous IgG from patients with SLE and drug-induced lupus by Teodorescu, M, Ustiyan, V, Russo, K, Rubin, R.L

“…The mechanism of attachment of circulating immune complexes (CIC) to glomerular basement membranes (GBM) in systemic lupus erythematosus (SLE) has not yet been…”
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Patients’ preimplantation genetic testing decision-making experience: an opinion on related psychological frameworks by Pastore, L M, Cordeiro Mitchell, C N, Rubin, L R, Nicoloro-SantaBarbara, J, Genoff Garzon, M C, Lobel, M

“…Abstract The process of deciding whether to pursue preimplantation genetic testing (PGT) of an embryo is highly stressful for individuals and couples and has…”
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Heterogeneity and clinical significance of glomerular-binding antibodies in systemic lupus erythematosus by Lefkowith, J B, Kiehl, M, Rubenstein, J, DiValerio, R, Bernstein, K, Kahl, L, Rubin, R L, Gourley, M

“…We used an ELISA employing extracts of human glomerular basement membrane (GBM) to detect, characterize, and evaluate the clinical significance of…”
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Analysis of the binding of C-reactive protein to histones and chromatin by Du Clos, TW, Zlock, LT, Rubin, RL

“…C-reactive protein (CRP) is an acute phase serum protein in man which binds to phosphocholine (PC) in a calcium-dependent manner. CRP has been shown to bind to…”
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A nondeletional mechanism for central T-cell tolerance by Rubin, R L, Kretz-Rommel, A

“…To be positively selected, immature thymocytes must receive signaling through their T-cell receptor (TCR), and engagement of relatively low-affinity…”
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Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex by RUBIN, R. L, BELL, S. A, BURLINGAME, R. W

“…IgG reactivity with the (H2A-H2B)-DNA complex, a subunit of the nucleosome, has been detected in many patients with lupus induced by procainamide and…”
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Antihistone antibody profile in sulfasalazine induced lupus by Bray, V J, West, S G, Schultz, K T, Boumpas, D T, Rubin, R L

“…Two patients developed drug induced lupus secondary to sulfasalazine (SSZ). One patient was receiving SSZ for Crohn's disease and was subsequently treated with…”
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Subnucleosome structures as substrates in enzyme-linked immunosorbent assays by Burlingame, R W, Rubin, R L

“…Histone preparations preserving the tertiary and quaternary structure of histone-histone complexes and histone-DNA complexes, as well as individual histones,…”
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IgG subclasses of autoantibodies in systemic lupus erythematosus, Sjogren's syndrome, and drug-induced autoimmunity by Rubin, RL, Tang, FL, Chan, EK, Pollard, KM, Tsay, G, Tan, EM

“…The IgG subclasses displayed by autoantibodies were examined in patients with systemic rheumatic diseases. Solid-phase assays performed with purified antigens…”
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Thymus Function in Drug-Induced Lupus by Rubin, R L, Salomon, D R, Guerrero, R S

“…Autoimmunity develops when a lupus-inducing drug is introduced into the thymus of normal mice, but the relevance of this model to the human disorder is unclear…”
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Association of antibody to histone complex H2A-H2B with symptomatic procainamide-induced lupus by Totoritis, M C, Tan, E M, McNally, E M, Rubin, R L

“…Antinuclear antibodies develop in most patients who are given prolonged procainamide therapy, but clinical symptoms resembling those of lupus appear in only 15…”
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Systemic lupus erythematosus induced by isoniazid by Salazar-Páramo, M, Rubin, R L, García-De La Torre, I

“…The case is described of a 73 year old man who presented with a lupus-like syndrome related to treatment with isoniazid and had IgG antinuclear antibodies…”
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Metabolism of procainamide to the cytotoxic hydroxylamine by neutrophils activated in vitro by RUBIN, R. L, CURNUTTE, J. T

“…An almost universal side effect of long-term therapy with procainamide is the appearance of serum autoantibodies and less frequently a syndrome resembling…”
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