Search Results - "Rubel, Edwin"

Rheotaxis in larval zebrafish is mediated by lateral line mechanosensory hair cells by Suli, Arminda, Watson, Glen M, Rubel, Edwin W, Raible, David W

“…The lateral line sensory system, found in fish and amphibians, is used in prey detection, predator avoidance and schooling behavior. This system includes cell…”
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Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death by Esterberg, Robert, Linbo, Tor, Pickett, Sarah B, Wu, Patricia, Ou, Henry C, Rubel, Edwin W, Raible, David W

“…Exposure to aminoglycoside antibiotics can lead to the generation of toxic levels of reactive oxygen species (ROS) within mechanosensory hair cells of the…”
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A brief history of hair cell regeneration research and speculations on the future by Rubel, Edwin W., Furrer, Stephanie A., Stone, Jennifer S.

“…Millions of people worldwide suffer from hearing and balance disorders caused by loss of the sensory hair cells that convert sound vibrations and head…”
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ER-mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damage by Esterberg, Robert, Hailey, Dale W, Rubel, Edwin W, Raible, David W

“…Mechanosensory hair cells are vulnerable to environmental insult, resulting in hearing and balance disorders. We demonstrate that directional compartmental…”
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Fractalkine Signaling Regulates Macrophage Recruitment into the Cochlea and Promotes the Survival of Spiral Ganglion Neurons after Selective Hair Cell Lesion by Kaur, Tejbeer, Zamani, Darius, Tong, Ling, Rubel, Edwin W, Ohlemiller, Kevin K, Hirose, Keiko, Warchol, Mark E

“…Macrophages are recruited into the cochlea in response to injury caused by acoustic trauma or ototoxicity, but the nature of the interaction between…”
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Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells by Hailey, Dale W, Esterberg, Robert, Linbo, Tor H, Rubel, Edwin W, Raible, David W

“…Aminoglycosides (AGs) are broad-spectrum antibiotics that are associated with kidney damage, balance disorders, and permanent hearing loss. This damage occurs…”
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Systematic and differential myelination of axon collaterals in the mammalian auditory brainstem by Seidl, Armin H., Rubel, Edwin W

“…A brainstem circuit for encoding the spatial location of sounds involves neurons in the cochlear nucleus that project to medial superior olivary (MSO) neurons…”
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Estimating relative abundances of proteins from shotgun proteomics data by McIlwain, Sean, Mathews, Michael, Bereman, Michael S, Rubel, Edwin W, MacCoss, Michael J, Noble, William Stafford

“…Spectral counting methods provide an easy means of identifying proteins with differing abundances between complex mixtures using shotgun proteomics data. The…”
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Notch Signaling Regulates the Extent of Hair Cell Regeneration in the Zebrafish Lateral Line by Ma, Eva Y, Rubel, Edwin W, Raible, David W

“…Mechanosensory hair cells within the zebrafish lateral line spontaneously regenerate after aminoglycoside-induced death. Exposure of 5-d-old larvae to 400…”
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Engineered deafness reveals that mouse courtship vocalizations do not require auditory experience by Mahrt, Elena J, Perkel, David J, Tong, Ling, Rubel, Edwin W, Portfors, Christine V

“…Auditory experience during development is necessary for normal language acquisition in humans. Although songbirds, some cetaceans, and maybe bats may also be…”
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Mechanisms for Adjusting Interaural Time Differences to Achieve Binaural Coincidence Detection by Seidl, Armin H, Rubel, Edwin W, Harris, David M

“…Understanding binaural perception requires detailed analyses of the neural circuitry responsible for the computation of interaural time differences (ITDs). In…”
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Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death by Owens, Kelly N, Santos, Felipe, Roberts, Brock, Linbo, Tor, Coffin, Allison B, Knisely, Anna J, Simon, Julian A, Rubel, Edwin W, Raible, David W

“…Inner ear sensory hair cell death is observed in the majority of hearing and balance disorders, affecting the health of more than 600 million people worldwide…”
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Differential conduction velocity regulation in ipsilateral and contralateral collaterals innervating brainstem coincidence detector neurons by Seidl, Armin H, Rubel, Edwin W, Barría, Andrés

“…Information processing in the brain relies on precise timing of signal propagation. The highly conserved neuronal network for computing spatial representations…”
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Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin by Golub, Justin S, Tong, Ling, Ngyuen, Tot B, Hume, Cliff R, Palmiter, Richard D, Rubel, Edwin W, Stone, Jennifer S

“…We developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse utricle by inserting the human diphtheria toxin…”
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Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss by Chowdhury, Sarwat, Owens, Kelly N, Herr, R. Jason, Jiang, Qin, Chen, Xinchao, Johnson, Graham, Groppi, Vincent E, Raible, David W, Rubel, Edwin W, Simon, Julian A

“…Hearing loss is a major public health concern with no pharmaceutical intervention for hearing protection or restoration. Using zebrafish neuromast hair cells,…”
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Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons by Tong, Ling, Strong, Melissa K, Kaur, Tejbeer, Juiz, Jose M, Oesterle, Elizabeth C, Hume, Clifford, Warchol, Mark E, Palmiter, Richard D, Rubel, Edwin W

“…During nervous system development, critical periods are usually defined as early periods during which manipulations dramatically change neuronal structure or…”
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Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity by Davis, Samantha N., Wu, Patricia, Camci, Esra D., Simon, Julian A., Rubel, Edwin W., Raible, David W.

“…Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the…”
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Bax, Bcl2, and p53 Differentially Regulate Neomycin- and Gentamicin-Induced Hair Cell Death in the Zebrafish Lateral Line by Coffin, Allison B., Rubel, Edwin W., Raible, David W.

“…Sensorineural hearing loss is a normal consequence of aging and results from a variety of extrinsic challenges such as excessive noise exposure and certain…”
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Cellular distribution of the fragile X mental retardation protein in the mouse brain by Zorio, Diego A.R., Jackson, Christine M., Liu, Yong, Rubel, Edwin W., Wang, Yuan

“…ABSTRACT The fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP results in abnormal neuronal…”
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Disruption of intracellular calcium regulation is integral to aminoglycoside-induced hair cell death by Esterberg, Robert, Hailey, Dale W, Coffin, Allison B, Raible, David W, Rubel, Edwin W

“…Intracellular Ca(2+) is a key regulator of life or death decisions in cultured neurons and sensory cells. The role of Ca(2+) in these processes is less clear…”
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