Search Results - "Rubas, W"

REVEAL: A phase I/II, open-label, multicenter, dose escalation and dose expansion study of NKTR-262 [TLR 7/8 agonist] plus NKTR-214 [CD122-biased agonist] with or without nivolumab (nivo) in patients (pts) with locally advanced or metastatic solid tumor malignancies by Diab, A, Marcondes, M, Tagliaferri, M A, Hoch, U, Zhang, J, Rubas, W, Kivimae, S, Zalevsky, J, Conley, A P, Borazanci, E, D'Angelo, S P

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In Vitro Models of the Intestinal Barrier: The Report and Recommendations of ECVAM Workshop 46 by Le Ferrec, Eric, Chesne, Christophe, Artusson, Per, Brayden, David, Fabre, Gérard, Gires, Pierre, Guillou, François, Rousset, Monique, Rubas, Werner, Scarino, Maria-Laura

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Flux measurements across Caco-2 monolayers may predict transport in human large intestinal tissue by Rubas, W, Cromwell, M E, Shahrokh, Z, Villagran, J, Nguyen, T N, Wellton, M, Nguyen, T H, Mrsny, R J

“…Confluent monolayers of Caco-2 cells, a human colonic carcinoma cell line, have been used extensively to predict intestinal absorption. A direct comparison of…”
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446TiPREVEAL: A phase I/II, open-label, multicenter, dose escalation and dose expansion study of NKTR-262 [TLR 7/8 agonist] plus NKTR-214 [CD122-biased agonist] with or without nivolumab (nivo) in patients (pts) with locally advanced or metastatic solid tumor malignancies by Diab, A, Marcondes, M, Tagliaferri, M A, Hoch, U, Zhang, J, Rubas, W, Kivimae, S, Zalevsky, J, Conley, A P, Borazanci, E, D'Angelo, S P

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306 - Intra-tumoral immune cell mobilization and anti-tumor activity after treatment with the engineered cytokine NKTR-214 in multiple preclinical mouse tumor models by Charych, D., Hennessy, M., Langowski, J., Dixit, V., Rubas, W., Hoch, U., Pena, R., Quach, P., Doberstein, S.K., Zaleveky, J.

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Combining complementary mechanisms of immune activation: NKTR-214, a biased IL-2 pathway agonist and immune checkpoint antagonists by Charych, D.H., Kuo, P., Addepalli, M., Dixit, V., Pena, R., Rubas, W., Hoch, U., Langowski, J., Doberstein, S.K., Zalevsky, J.

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A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model by Delie, F, Rubas, W

“…Caco-2 cell monolayers mimic intestinal absorptive epithelium and represent a very useful tool for studying transepithelial transport. The literature on Caco-2…”
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Treatment of murine L1210 lymphoid leukemia and melanoma B16 with lipophilic cytosine arabinoside prodrugs incorporated into unilamellar liposomes by Rubas, W, Supersaxo, A, Weder, H G, Hartmann, H R, Hengartner, H, Schott, H, Schwendener, R

“…Lipophilic prodrugs of I-beta-D-arabinofuranosyl cytosine (Ara-C), namely N4- and 5'-oleyl-I-beta-D-arabinofuranosyl cytosine (N4-oleyl-ara-C, 5'-oleyl-ara-C)…”
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Incorporation of the reovirus M cell attachment protein into small unilamellar vesicles: incorporation efficiency and binding capability to L929 cells in vitro by Rubas, W, Banerjea, A C, Gallati, H, Speiser, P P, Joklik, W K

“…Neutral phosphatidylcholine/cholesterol (10 : 3) liposomes with the reovirus M cell attachment protein sigma 1 were made by means of detergent dialysis method…”
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P-Glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: the influence of culturing conditions and drug exposure on P-gp expression levels by Anderle, P, Niederer, E, Rubas, W, Hilgendorf, C, Spahn-Langguth, H, Wunderli-Allenspach, H, Merkle, H P, Langguth, P

“…The influence of cell culture conditions and previous drug exposure on P-glycoprotein (P-gp) expression levels in Caco-2 cells was determined. In this study,…”
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CKD-MBD - A by Stracke, S., Sonntagbauer, M., Aymanns, C., Dabers, T., Cammerer, G., Henne-Bruns, D., Wurl, P., Keller, F., Floege, J., Covic, A., Ketteler, M., Rastogi, A., Chong, E., Lisk, L., Sprague, S., Gaillard, S., Lopfe, M., Wilhelm, M., Funk, F., Kalia, V., Willsie, S., Winkle, P., Block, G. A., Persky, M. S., Shamblin, B. M., Baltazar, M. F., Comelli, M. C., Lu, Y.-A., Liu, Y.-C., Lee, S.-Y., Hsu, H.-H., Chen, Y.-C., Yu, C.-C., Hung, C.-C., Yang, C.-W., Dixit, V., Cheng, L., Zhang, J., Tonkin, E., Jaladi, R., Obalapur, P., Dodda, S., Shrivastava, W., Dama, S., Kesana, S., Fry, D., Rubas, W., Martin, D., Riggs, J., Kantak, S., Harrison, S., Doberstein, S., Tartaglione, L., Pasquali, M., Leonangeli, C., Mandanici, G., Muci, M. L., Rotondi, S., Silas, S., Mazzaferro, S., Fusaro, M., Noale, M., Tripepi, G., Piccoli, A., Naso, A., Giannini, S., Miozzo, D., Venturelli, C., Pica, A., Brunori, G., Cristofaro, R., Gallieni, M., Shin, J.-h., Kim, S. H., Yu, S.-H., Martins, J., Castro, J. H., Vogt, B., Oliveira, R., Jorgetti, V., Caramori, J. T., Scully, P., O'Flaherty, D., Sankaralingam, A., Hampson, G., Goldsmith, D., Hadjiyannakos, D., Milatos, G., Filiopoulos, V., Sonikian, M., Karatzas, I., Vlassopoulos, D., Ullah, A., Abdulnabi, K., Gallagher, P., Khalil, A., Alexander, J., Mishra, V., Pai, P., Kang, G. W.

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5'-O-Palmitoyl- and 3',5'-O-dipalmitoyl-5-fluoro-2'-deoxyuridine--novel lipophilic analogues of 5'-fluoro-2'-deoxyuridine: synthesis, incorporation into liposomes and preliminary biological results by Schwendener, R A, Supersaxo, A, Rubas, W, Weder, H G, Hartmann, H R, Schott, H, Ziegler, A, Hengartner, H

“…5'-O-palmitoyl- and 3',5'-O-dipalmitoyl-5-fluoro-2'-deoxyuridine were prepared by the reaction of 5-fluoro-2'-deoxyuridine in dimethylacetamide with palmitic…”
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Comparison of the permeability characteristics of a human colonic epithelial (caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption by RUBAS, W, JEZYK, N, GRASS, G. M

“…The in vitro permeabilities of Caco-2 monolayers and permeabilities in tissue sections from colon of monkey, rabbit, and dog were compared using a series of…”
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Translocation of Human Calcitonin in Respiratory Nasal Epithelium Is Associated with Self-Assembly in Lipid Membrane by Schmidt, Maria Christiane, Rothen-Rutishauser, Barbara, Rist, Beate, Beck-Sickinger, Annette, Wunderli-Allenspach, Heidi, Rubas, Werner, Sadée, Wolfgang, Merkle, Hans Peter

“…We studied the mechanisms involved in the translocation of human calcitonin (hCT) through excised bovine nasal mucosa (net mucosal-to-serosal permeability…”
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Validation of excised bovine nasal mucosa as in vitro model to study drug transport and metabolic pathways in nasal epithelium by Schmidt, M C, Simmen, D, Hilbe, M, Boderke, P, Ditzinger, G, Sandow, J, Lang, S, Rubas, W, Merkle, H P

“…The present work aims at the validation of excised bovine nasal mucosa as an in vitro model to address transport and metabolism pathways relative to the nasal…”
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In vitro assessment of intestinal IGF-I stability by Anderle, Pascale, Langguth, Peter, Rubas, Werner, Merkle, Hans P

“…Insulin-like growth factor (IGF-I) is a 7648-Da polypeptide consisting of 70 amino acids. Clinically, IGF-I might be used in type II diabetes, which requires a…”
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The effect of chemical modifications on octanol/water partition (log D) and permeabilities across Caco-2 monolayers: In vitro models for selection of development candidates by RUBAS, W, CROMWELL, M. E. M

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In vitro evaluation of dexamethasone-β-D-glucuronide for colon-specific drug delivery by HAEBERLIN, B, RUBAS, W, NOLEN, H. W, FRIEND, D. R

“…Dexamethasone-beta-D-glucuronide is a potential prodrug for colonic delivery of the antiinflammatory corticosteroid dexamethasone. Previous studies [T. R…”
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