Search Results - "Rubío, Rebeca Alba"

Ewing sarcoma partial regression without GvHD by chondromodulin-I/HLA-A02:01-specific allorestricted T cell receptor transgenic T cells by Thiel, Uwe, Schober, Sebastian J., Einspieler, Ingo, Kirschner, Andreas, Thiede, Melanie, Schirmer, David, Gall, Katja, Blaeschke, Franziska, Schmidt, Oxana, Jabar, Susanne, Ranft, Andreas, Alba Rubío, Rebeca, Dirksen, Uta, Grunewald, Thomas G. P., Sorensen, Poul H., Richter, Günther H. S., von Lüttichau, Irene Teichert, Busch, Dirk H., Burdach, Stefan E. G.

“…Background: Chondromodulin-I (CHM1) sustains malignancy in Ewing sarcoma (ES). Refractory ES carries a dismal prognosis and patients with bone marrow (BM)…”
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Transgenic antigen-specific, HLA-A02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity by Schirmer, David, Grünewald, Thomas G. P., Klar, Richard, Schmidt, Oxana, Wohlleber, Dirk, Rubío, Rebeca Alba, Uckert, Wolfgang, Thiel, Uwe, Bohne, Felix, Busch, Dirk H., Krackhardt, Angela M., Burdach, Stefan, Richter, Günther H. S.

“…Pediatric cancers, including Ewing sarcoma (ES), are only weakly immunogenic and the tumor-patients' immune system often is devoid of effector T cells for…”
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Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma by Dallmayer, Marlene, Li, Jing, Ohmura, Shunya, Alba Rubio, Rebeca, Baldauf, Michaela C., Hölting, Tilman L. B., Musa, Julian, Knott, Max M. L., Stein, Stefanie, Cidre-Aranaz, Florencia, Wehweck, Fabienne S., Romero-Pérez, Laura, Gerke, Julia S., Orth, Martin F., Marchetto, Aruna, Kirchner, Thomas, Bach, Horacio, Sannino, Giuseppina, Grünewald, Thomas G. P.

“…Ewing sarcoma (EwS) is an aggressive cancer characterized by chromosomal translocations generating fusions of the EWSR1 gene with ETS transcription factors (in…”
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Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo by Kirschner, Andreas, Thiede, Melanie, Grünewald, Thomas G. P., Alba Rubio, Rebeca, Richter, Günther H. S., Kirchner, Thomas, Busch, Dirk H., Burdach, Stefan, Thiel, Uwe

“…Pregnancy-associated plasma protein-A (PAPPA), also known as pappalysin, is a member of the insulin-like growth factor (IGF) family. PAPPA acts as a protease,…”
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Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis by Broadfield, Lindsay A, Duarte, João André Gonçalves, Schmieder, Roberta, Broekaert, Dorien, Veys, Koen, Planque, Mélanie, Vriens, Kim, Karasawa, Yasuaki, Napolitano, Francesco, Fujita, Suguru, Fujii, Masashi, Eto, Miki, Holvoet, Bryan, Vangoitsenhoven, Roman, Fernandez-Garcia, Juan, Van Elsen, Joke, Dehairs, Jonas, Zeng, Jia, Dooley, James, Rubio, Rebeca Alba, van Pelt, Jos, Grünewald, Thomas G P, Liston, Adrian, Mathieu, Chantal, Deroose, Christophe M, Swinnen, Johannes V, Lambrechts, Diether, di Bernardo, Diego, Kuroda, Shinya, De Bock, Katrien, Fendt, Sarah-Maria

“…Hepatic fat accumulation is associated with diabetes and hepatocellular carcinoma (HCC). Here, we characterize the metabolic response that high-fat…”
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Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets by Baldauf, Michaela C, Orth, Martin F, Dallmayer, Marlene, Marchetto, Aruna, Gerke, Julia S, Rubio, Rebeca Alba, Kiran, Merve M, Musa, Julian, Knott, Maximilian M L, Ohmura, Shunya, Li, Jing, Akpolat, Nusret, Akatli, Ayse N, Özen, Özlem, Dirksen, Uta, Hartmann, Wolfgang, de Alava, Enrique, Baumhoer, Daniel, Sannino, Giuseppina, Kirchner, Thomas, Grünewald, Thomas G P

“…Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular detection of pathognomonic fusions such as enables definitive diagnosis,…”
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Systematic identification of cancer-specific MHC-binding peptides with RAVEN by Baldauf, Michaela C., Gerke, Julia S., Kirschner, Andreas, Blaeschke, Franziska, Effenberger, Manuel, Schober, Kilian, Rubio, Rebeca Alba, Kanaseki, Takayuki, Kiran, Merve M., Dallmayer, Marlene, Musa, Julian, Akpolat, Nurset, Akatli, Ayse N., Rosman, Fernando C., Özen, Özlem, Sugita, Shintaro, Hasegawa, Tadashi, Sugimura, Haruhiko, Baumhoer, Daniel, Knott, Maximilian M. L., Sannino, Giuseppina, Marchetto, Aruna, Li, Jing, Busch, Dirk H., Feuchtinger, Tobias, Ohmura, Shunya, Orth, Martin F., Thiel, Uwe, Kirchner, Thomas, Grünewald, Thomas G. P.

“…Immunotherapy can revolutionize anti-cancer therapy if specific targets are available. Immunogenic peptides encoded by cancer-specific genes (CSGs) may enable…”
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Abstract 4515: Metabolic stress sensor MondoA mediates in vivo aggressiveness of common ALL by induction of HIF1α by Sipol, Alexandra A., Grunewald, Thomas G., Schmaeh, Juliane, Boer, Monique L. den, Rubío, Rebeca Alba, Baldauf, Michaela, Wernicke, Caroline, Horstmann, Martin, Cario, Gunnar, Richter, Günther, Burdach, Stefan

“…Tumor cells evolve adaptive mechanisms to survive hypoxia, nutrient deprivation, oxidative or genotoxic stress to ultimately drive tumor progression (Sorensen…”
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Abstract 2462: MondoA mediates in vivo aggressiveness of common ALL and may serve as a T-cell immunotherapy target by Sipol, Alexandra, Grunewald, Thomas G. P., Schmaeh, Juliane, Schirmer, David, den Boer, Monique L., Alba Rubío, Rebeca, Baldauf, Michaela, Wernicke, Caroline, Kolb, Hans-Jochem, Horstmann, Martin, Cario, Gunnar, Richter, Guünther, Burdach, Stefan

“…Oncogene addiction provides ideal targets for immunotherapy. We previously described MondoA (also known as MLXIP, MAX like protein X interacting protein) as a…”
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MondoA drives malignancy in B-ALL through enhanced adaptation to metabolic stress by Sipol, Alexandra, Hameister, Erik, Xue, Busheng, Hofstetter, Julia, Barenboim, Maxim, Öllinger, Rupert, Jain, Gaurav, Prexler, Carolin, Rubio, Rebeca Alba, Baldauf, Michaela C., Franchina, Davide G., Petry, Andreas, Schmäh, Juliane, Thiel, Uwe, Görlach, Agnes, Cario, Gunnar, Brenner, Dirk, Richter, Günther H.S., Grünewald, Thomas G.P., Rad, Roland, Wolf, Elmar, Ruland, Jürgen, Sorensen, Poul H., Burdach, Stefan E.G.

“…Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced…”
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Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding by Lee, Olivia W., Rodrigues, Calvin, Lin, Shu-Hong, Luo, Wen, Jones, Kristine, Brown, Derek W., Zhou, Weiyin, Karlins, Eric, Khan, Sairah M., Baulande, Sylvain, Raynal, Virginie, Surdez, Didier, Reynaud, Stephanie, Rubio, Rebeca Alba, Zaidi, Sakina, Grossetête, Sandrine, Ballet, Stelly, Lapouble, Eve, Laurence, Valérie, Pierron, Gaelle, Gaspar, Nathalie, Corradini, Nadège, Marec-Bérard, Perrine, Rothman, Nathaniel, Dagnall, Casey L., Burdett, Laurie, Manning, Michelle, Wyatt, Kathleen, Yeager, Meredith, Chari, Raj, Leisenring, Wendy M., Kulozik, Andreas E., Kriebel, Jennifer, Meitinger, Thomas, Strauch, Konstantin, Kirchner, Thomas, Dirksen, Uta, Mirabello, Lisa, Tucker, Margaret A., Tirode, Franck, Armstrong, Gregory T., Bhatia, Smita, Robison, Leslie L., Yasui, Yutaka, Romero-Pérez, Laura, Hartmann, Wolfgang, Metzler, Markus, Diver, W. Ryan, Lori, Adriana, Freedman, Neal D., Hoover, Robert N., Morton, Lindsay M., Chanock, Stephen J., Grünewald, Thomas G.P., Delattre, Olivier, Machiela, Mitchell J.

“…Ewing sarcoma (EwS) is a rare bone and soft tissue malignancy driven by chromosomal translocations encoding chimeric transcription factors, such as EWSR1-FLI1,…”
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Fat induces glucose metabolism in non-transformed liver cells and promotes liver tumorigenesis by Broadfield, Lindsay A., Duarte, João André Gonçalves, Schmieder, Roberta, Broekaert, Dorien, Veys, Koen, Planque, Mélanie, Vriens, Kim, Karasawa, Yasuaki, Napolitano, Francesco, Fujita, Suguru, Fujii, Masashi, Eto, Miki, Holvoet, Bryan, Vangoitsenhoven, Roman, Fernandez-Garcia, Juan, Van Elsen, Joke, Dehairs, Jonas, Zeng, Jia, Dooley, James, Rubio, Rebeca Alba, van Pelt, Jos, Grünewald, Thomas G.P., Liston, Adrian, Mathieu, Chantal, Deroose, Christophe M., Swinnen, Johannes V., Lambrechts, Diether, di Bernardo, Diego, Kuroda, Shinya, De Bock, Katrien, Fendt, Sarah-Maria

“…Hepatic fat accumulation is associated with diabetes and hepatocellular carcinoma (HCC). Here we characterize the metabolic response that high fat availability…”
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Abstract 692: Pappalysin-1 is a suitable target for T cell receptor transgenic T cells to kill Ewing sarcoma in vivo and in vitro by Thiel, Uwe, Kirschner, Andreas, Thiede, Melanie, Grünewald, Thomas GP, Rubio, Rebeca Alba, Richter, Günther, Kirchner, Thomas, Busch, Dirk, Sorensen, Poul, Burdach, Stefan

“…Pregnancy-associated plasma protein-A (PAPPA), also known as pappalysin, is a member of the insulin like growth factor (IGF) family. PAPPA acts as a protease,…”
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Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma by Orth, Martin F., Gerke, Julia S., Knösel, Thomas, Altendorf‐Hofmann, Annelore, Musa, Julian, Alba‐Rubio, Rebeca, Stein, Stefanie, Hölting, Tilman L. B., Cidre‐Aranaz, Florencia, Romero‐Pérez, Laura, Dallmayer, Marlene, Baldauf, Michaela C., Marchetto, Aruna, Sannino, Giuseppina, Knott, Maximilian M. L., Wehweck, Fabienne, Ohmura, Shunya, Li, Jing, Hakozaki, Michiyuki, Kirchner, Thomas, Dandekar, Thomas, Butt, Elke, Grünewald, Thomas G. P.

“…Soft‐tissue sarcomas are rare, heterogeneous, and often aggressive mesenchymal cancers. Many of them are associated with poor outcome, partially because…”
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Human HLA-A02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo by Blaeschke, Franziska, Thiel, Uwe, Kirschner, Andreas, Thiede, Melanie, Rubio, Rebeca Alba, Schirmer, David, Kirchner, Thomas, Richter, Günther H S, Mall, Sabine, Klar, Richard, Riddell, Stanley, Busch, Dirk H, Krackhardt, Angela, Grunewald, Thomas G P, Burdach, Stefan

“…The endochondral bone protein Chondromodulin-I (CHM1) provides oncogene addiction in Ewing sarcoma (ES). We pre-clinically tested the targetability of CHM1 by…”
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Abstract A13: Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility by Machiela, Mitchell J., Grünewald, Thomas G.P., Surdez, Didier, Reynaud, Stephanie, Mirabeau, Olivier, Karlins, Eric, Rubio, Rebeca Alba, Zaidi, Sakina, Grossetete-Lalami, Sandrine, Ballet, Stelly, Lapouble, Eve, Laurence, Valérie, Michon, Jean, Pierron, Gaelle, Kovar, Heinrich, Gaspar, Nathalie, Kontny, Udo, González-Neira, Anna, Picci, Piero, Alonso, Javier, Patino-Garcia, Ana, Corradini, Nadège, Freedman, Neal D., Rothman, Nathaniel, Dagnall, Casey L., Burdett, Laurie, Jones, Kristine, Manning, Michelle, Wyatt, Kathleen, Zhou, Weiyin, Yeager, Meredith, Cox, David G., Hoover, Robert N., Khan, Javed, Armstrong, Gregory T., Leisenring, Wendy M., Bhatia, Smita, Robison, Leslie L., Dirksen, Uta, Metzler, Markus, Hartmann, Wolfgang, Strauch, Konstantin, Kirchner, Thomas, Kulozik, Andreas E., Morton, Lindsay M., Mirabello, Lisa, Tucker, Margaret A., Tirode, Franck, Chanock, Stephen, Delattre, Olivier

“…Ewing sarcoma (EWS), a pediatric tumor predominantly occurring in children of European ancestry, is characterized by the EWSR1-FLI1 fusion oncogene. We…”
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Abstract 2970: Multiple new susceptibility loci identified in genome-wide association study of Ewing sarcoma by Machiela, Mitchell J., Grünewald, Thomas G., Surdez, Didier, Reynaud, Stephanie, Mirabeau, Olivier, Karlins, Eric, Rubio, Rebeca Alba, Zaidi, Sakina, Grossetete-Lalami, Sandrine, Ballet, Stelly, Lapouble, Eve, Laurence, Valérie, Michon, Jean, Pierron, Gaelle, Kovar, Heinrich, Gaspar, Nathalie, Kontny, Udo, González-Neira, Anna, Picci, Piero, Alonso, Javier, Patino-Garcia, Ana, Corradini, Nadège, Freedman, Neal D., Rothman, Nathaniel, Dagnall, Casey L., Burdette, Laurie, Jones, Kristine, Manning, Michelle, Wyatt, Kathleen, Zhou, Weiyin, Yeager, Meredith, Cox, David G., Hoover, Robert N., Khan, Javed, Armstrong, Gregory T., Leisenring, Wendy M., Bhatia, Smita, Robison, Leslie L., Dirksen, Uta, Metzler, Markus, Hartmann, Wolfgang, Strauch, Konstantin, Kirchner, Thomas, Kulozik, Andreas E., Morton, Lindsay M., Mirabello, Lisa, Tucker, Margaret A., Tirode, Franck, Chanock, Stephen J., Delattre, Olivier

“…Ewing sarcoma (EWS) is a rare pediatric tumor predominantly occurring in children of European ancestry and is characterized by the pathognomonic EWSR1-FLI1…”
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Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients by Sannino, Giuseppina, Marchetto, Aruna, Ranft, Andreas, Jabar, Susanne, Zacherl, Constanze, Alba-Rubio, Rebeca, Stein, Stefanie, Wehweck, Fabienne S., Kiran, Merve M., Hölting, Tilman L.B., Musa, Julian, Romero-Pérez, Laura, Cidre-Aranaz, Florencia, Knott, Maximilian M.L., Li, Jing, Jürgens, Heribert, Sastre, Ana, Alonso, Javier, Da Silveira, Willian, Hardiman, Gary, Gerke, Julia S., Orth, Martin F., Hartmann, Wolfgang, Kirchner, Thomas, Ohmura, Shunya, Dirksen, Uta, Grünewald, Thomas G.P.

“…Up to 30–40% of Ewing sarcoma (EwS) patients with non-metastatic disease develop local or metastatic relapse within a time span of 2–10 years. This is in part…”
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Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patientsResearch in context by Giuseppina Sannino, Aruna Marchetto, Andreas Ranft, Susanne Jabar, Constanze Zacherl, Rebeca Alba-Rubio, Stefanie Stein, Fabienne S. Wehweck, Merve M. Kiran, Tilman L.B. Hölting, Julian Musa, Laura Romero-Pérez, Florencia Cidre-Aranaz, Maximilian M.L. Knott, Jing Li, Heribert Jürgens, Ana Sastre, Javier Alonso, Willian Da Silveira, Gary Hardiman, Julia S. Gerke, Martin F. Orth, Wolfgang Hartmann, Thomas Kirchner, Shunya Ohmura, Uta Dirksen, Thomas G.P. Grünewald

“…Background: Up to 30–40% of Ewing sarcoma (EwS) patients with non-metastatic disease develop local or metastatic relapse within a time span of 2–10 years. This…”
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