Search Results - "Rubí, B"

Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells by Aragón, F, Karaca, M, Novials, A, Maldonado, R, Maechler, P, Rubí, B

“…Plasma levels of pancreatic polypeptide (PP) rise upon food intake. Although other pancreatic islet hormones, such as insulin and glucagon, have been…”
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Pyridoxal 5’-phosphate (PLP) deficiency might contribute to the onset of type I diabetes by Rubí, B

“…Abstract The incidence of type I diabetes is rising worldwide, particularly in young children. Type I diabetes is considered a multifactorial disease with…”
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Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues by Morillas, M, Clotet, J, Rubí, B, Serra, D, Ariño, J, Hegardt, F G, Asins, G

“…Rat peroxisomal carnitine octanoyltransferase (COT), which facilitates the transport of medium-chain fatty acids through the peroxisomal membrane, is…”
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Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function by DE ANDRADE, P. B. M, RUBI, B, FRIGERIO, F, VAN DEN OUWELAND, J. M. W, MAASSEN, J. A, MAECHLER, P

“…Mitochondrial DNA (mtDNA) mutations cause several diseases, including mitochondrial inherited diabetes and deafness (MIDD), typically associated with the mtDNA…”
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Identification of the two histidine residues responsible for the inhibition by malonyl-CoA in peroxisomal carnitine octanoyltransferase from rat liver by Morillas, Montserrat, Clotet, Josep, Rubı́, Blanca, Serra, Dolors, Asins, Guillermina, Ariño, Joaquı́n, Hegardt, Fausto G.

“…Carnitine octanoyltransferase (COT), an enzyme that facilitates the transport of medium chain fatty acids through peroxisomal membranes, is inhibited by…”
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Dopamine modulates von Willebrand factor secretion in endothelial cells via D2–D4 receptors by ZAREI, S., FRIEDEN, M., RUBI, B., VILLEMIN, P., GAUTHIER, B. R., MAECHLER, P., VISCHER, U. M.

“…Objective: von Willebrand factor (VWF) is acutely released from endothelial cells in response to numerous calcium‐raising agents (e.g. thrombin, histamine) and…”
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New insights into amino acid metabolism, beta-cell function and diabetes by Newsholme, Philip, Brennan, Lorraine, Rubi, Blanca, Maechler, Pierre

“…Specific amino acids are now known to acutely and chronically regulate insulin secretion from pancreatic beta-cells in vivo and in vitro. Understanding the…”
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Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells by Merglen, Arnaud, Theander, Sten, Rubi, Blanca, Chaffard, Gaelle, Wollheim, Claes B, Maechler, Pierre

“…Rat insulinoma-derived INS-1 cells constitute a widely used β-cell surrogate. However, due to their nonclonal nature, INS-1 cells are heterogeneous and are not…”
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No Association between ABCB1 G2677T/A or C3435T Polymorphisms and Survival of Breast Cancer Patients-A 10-Year Follow-Up Study in the Polish Population by Totoń, Ewa, Jacczak, Barbara, Barczak, Wojciech, Jagielski, Paweł, Gryczka, Robert, Hołysz, Hanna, Grodecka-Gazdecka, Sylwia, Rubiś, Błażej

“…Many intensive studies are devoted to identifying novel cancer diagnostics or therapy strategies that would boost cancer therapy efficacy and recovery rates…”
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In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion by Maechler, Pierre, Carobbio, Stefania, Rubi, Blanca

“…Pancreatic beta-cells are unique neuroendocrine cells displaying the peculiar feature of responding to nutrients, principally glucose, as primary stimulus…”
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Peroxisome Proliferator-Activated Receptor α (PPARα) Potentiates, whereas PPARγ Attenuates, Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells by Ravnskjaer, Kim, Boergesen, Michael, Rubi, Blanca, Larsen, Jan K, Nielsen, Tina, Fridriksson, Jakob, Maechler, Pierre, Mandrup, Susanne

“…Fatty acids (FAs) are known to be important regulators of insulin secretion from pancreatic β-cells. FA-coenzyme A esters have been shown to directly stimulate…”
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Impact of common ABCB1 polymorphism on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites by Karaźniewicz-Łada, M., Danielak, D., Rubiś, B., Burchardt, P., Komosa, A., Lesiak, M., Główka, F.

“…Summary What is known and objective The reasons of clopidogrel (CLP) resistance are still unclear. The response to CLP may be influenced by both genetic and…”
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The Malate-Aspartate NADH Shuttle Member Aralar1 Determines Glucose Metabolic Fate, Mitochondrial Activity, and Insulin Secretion in Beta Cells by Rubi, Blanca, del Arco, Araceli, Bartley, Clarissa, Satrustegui, Jorgina, Maechler, Pierre

“…The NADH shuttle system, which transports reducing equivalents from the cytosol to the mitochondria, is essential for the coupling of glucose metabolism to…”
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Dopamine D2-like Receptors Are Expressed in Pancreatic Beta Cells and Mediate Inhibition of Insulin Secretion by Rubí, Blanca, Ljubicic, Sanda, Pournourmohammadi, Shirin, Carobbio, Stefania, Armanet, Mathieu, Bartley, Clarissa, Maechler, Pierre

“…Dopamine signaling is mediated by five cloned receptors, grouped into D1-like (D1 and D5) and D2-like (D2, D3 and D4) families. We identified by reverse…”
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Alteration of the Malonyl-CoA/Carnitine Palmitoyltransferase I Interaction in the β-Cell Impairs Glucose-Induced Insulin Secretion by HERRERO, Laura, RUBI, Blanca, SEBASTIAN, David, SERRA, Dolors, ASINS, Guillermina, MAECHLER, Pierre, PRENTKI, Marc, HEGARDT, Fausto G

“…Alteration of the M alonyl- CoA /Carnitine Palmitoyltransferase I Interaction in the β-Cell Impairs Glucose-Induced Insulin Secretion Laura Herrero 1 , Blanca…”
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Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion by Rubí, Blanca, Antinozzi, Peter A, Herrero, Laura, Ishihara, Hisamitsu, Asins, Guillermina, Serra, Dolors, Wollheim, Claes B, Maechler, Pierre, Hegardt, Fausto G

“…Lipid metabolism in the beta-cell is critical for the regulation of insulin secretion. Pancreatic beta-cells chronically exposed to fatty acids show higher…”
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GAD65-mediated Glutamate Decarboxylation Reduces Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells by Rubi, Blanca, Ishihara, Hisamitsu, Hegardt, Fausto G., Wollheim, Claes B., Maechler, Pierre

“…Mitochondrial metabolism plays a pivotal role in the pancreatic beta cell by generating signals that couple glucose sensing to insulin secretion. We have…”
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ORIGINAL ARTICLE: Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors by Zarei, S, Frieden, M, Rubi, B, Villemin, P, Gauthier, B R, Maechler, P, Vischer, U M

“…Objective: von Willebrand factor (VWF) is acutely released from endothelial cells in response to numerous calcium-raising agents (e.g. thrombin, histamine) and…”
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Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain by Morillas, Montserrat, Gómez-Puertas, Paulino, Rubí, Blanca, Clotet, Josep, Ariño, Joaquín, Valencia, Alfonso, Hegardt, Fausto G, Serra, Dolors, Asins, Guillermina

“…Carnitine octanoyltransferase (COT) and carnitine palmitoyltransferase (CPT) I, which facilitate the transport of medium- and long-chain fatty acids through…”
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Robust estimation of causal effects of binary treatments in unconfounded studies with dichotomous outcomes by Gutman, R., Rubin, D.B.

“…The estimation of causal effects has been the subject of extensive research. In unconfounded studies with a dichotomous outcome, Y, Cangul, Chretien, Gutman…”
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