Search Results - "Ruark, Christopher D."

Development of a physiologically based model to describe the pharmacokinetics of methylphenidate in juvenile and adult humans and nonhuman primates by Yang, Xiaoxia, Morris, Suzanne M, Gearhart, Jeffery M, Ruark, Christopher D, Paule, Merle G, Slikker, Jr, William, Mattison, Donald R, Vitiello, Benedetto, Twaddle, Nathan C, Doerge, Daniel R, Young, John F, Fisher, Jeffrey W

“…The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development…”
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Organophosphorus Inhibition and Characterization of Recombinant Guinea Pig Acetylcholinesterase by Ruark, Christopher D, Chapleau, Richard R, Mahle, Deirdre A, Gearhart, Jeffery M

“…Organophosphorus (OP) pesticides and nerve agents have been designed to inhibit the hydrolysis of the neurotransmitter acetylcholine by covalently binding to…”
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Quantitative bias analysis for epidemiological associations of perfluoroalkyl substance serum concentrations and early onset of menopause by Ruark, Christopher D., Song, Gina, Yoon, Miyoung, Verner, Marc-André, Andersen, Melvin E., Clewell, Harvey J., Longnecker, Matthew P.

“…An association between increased serum concentrations of perfluoroalkyl substances (PFAS) such as perfluorooctane sulfonate (PFOS) and perfluorooctanoate…”
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Predicting passive and active tissue:plasma partition coefficients: interindividual and interspecies variability by Ruark, Christopher D, Hack, C Eric, Robinson, Peter J, Mahle, Deirdre A, Gearhart, Jeffery M

“…A mechanistic tissue composition model incorporating passive and active transport for the prediction of steady-state tissue:plasma partition coefficients…”
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Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use by Ngueta, Gerard, Longnecker, Matthew P., Yoon, Miyoung, Ruark, Christopher D., Clewell, Harvey J., Andersen, Melvin E., Verner, Marc-André

“…An association between serum levels of perfluoroalkyl substances (PFAS) and endometriosis has recently been reported in an epidemiologic study. Oral…”
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A physiologically based pharmacokinetic model for the oxime TMB-4: simulation of rodent and human data by Sterner, Teresa R., Ruark, Christopher D., Covington, Tammie R., Yu, Kyung O., Gearhart, Jeffery M.

“…Multiple oximes have been synthesized and evaluated for use as countermeasures against chemical warfare nerve agents. The current U.S. military and civilian…”
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Quantitative structure–activity relationships for organophosphates binding to acetylcholinesterase by Ruark, Christopher D., Hack, C. Eric, Robinson, Peter J., Anderson, Paul E., Gearhart, Jeffery M.

“…Organophosphates are a group of pesticides and chemical warfare nerve agents that inhibit acetylcholinesterase, the enzyme responsible for hydrolysis of the…”
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High-Throughput Screening for Positive Allosteric Modulators Identified Potential Therapeutics against Acetylcholinesterase Inhibition by Chapleau, Richard R, McElroy, Craig A, Ruark, Christopher D, Fleming, Emily J, Ghering, Amy B, Schlager, John J, Poeppelman, Lee D, Gearhart, Jeffery M

“…The current standard of care for treatment of organophosphate (OP) poisoning includes pretreatment with the weak reversible acetylcholinesterase (AChE)…”
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Quantitative Structure-Activity Relationships for Organophosphates Binding to Trypsin and Chymotrypsin by Ruark, Christopher D., Hack, C. Eric, Robinson, Peter J., Gearhart, Jeffery M.

“…Organophosphate (OP) nerve agents such as sarin, soman, tabun, and O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate (VX) do not react solely with…”
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