Search Results - "Ruan, Jinxue"

MiCas9 increases large size gene knock-in rates and reduces undesirable on-target and off-target indel edits by Ma, Linyuan, Ruan, Jinxue, Song, Jun, Wen, Luan, Yang, Dongshan, Zhao, Jiangyang, Xia, Xiaofeng, Chen, Y. Eugene, Zhang, Jifeng, Xu, Jie

“…Gene editing nuclease represented by Cas9 efficiently generates DNA double strand breaks at the target locus, followed by repair through either the error-prone…”
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CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replication by Zhao, Changzhi, Liu, Hailong, Xiao, Tianhe, Wang, Zichang, Nie, Xiongwei, Li, Xinyun, Qian, Ping, Qin, Liuxing, Han, Xiaosong, Zhang, Jinfu, Ruan, Jinxue, Zhu, Mengjin, Miao, Yi-Liang, Zuo, Bo, Yang, Kui, Xie, Shengsong, Zhao, Shuhong

“…Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic flavivirus that causes encephalitis and reproductive disorders in mammalian species. However,…”
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Advances in CRISPR-Based Functional Genomics and Nucleic Acid Detection in Pigs by Ruan, Jinxue, Zhang, Xuying, Zhao, Shuhong, Xie, Shengsong

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Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs by Ruan, Jinxue, Li, Hegang, Xu, Kui, Wu, Tianwen, Wei, Jingliang, Zhou, Rong, Liu, Zhiguo, Mu, Yulian, Yang, Shulin, Ouyang, Hongsheng, Yanru Chen-Tsai, Ruby, Li, Kui

“…Transgenic pigs play an important role in producing higher quality food in agriculture and improving human health when used as animal models for various human…”
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Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting by Song, Jun, Yang, Dongshan, Ruan, Jinxue, Zhang, Jifeng, Chen, Yuqing Eugene, Xu, Jie

“…Immunodeficient mice have been used predominantly in biomedical research. Realizing that large animal species may have an enhanced ability to predict clinical…”
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Efficient Gene Editing at Major CFTR Mutation Loci by Ruan, Jinxue, Hirai, Hiroyuki, Yang, Dongshan, Ma, Linyuan, Hou, Xia, Jiang, Hong, Wei, Hongguang, Rajagopalan, Carthic, Mou, Hongmei, Wang, Guoshun, Zhang, Jifeng, Li, Kui, Chen, Yuqing E., Sun, Fei, Xu, Jie

“…Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene…”
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Long-term, multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production by Fan, Ziyao, Liu, Zhiguo, Xu, Kui, Wu, Tianwen, Ruan, Jinxue, Zheng, Xinmin, Bao, Shideng, Mu, Yulian, Sonstegard, Tad, Li, Kui

“…Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin ( MSTN ), but a lack of diversity in the MSTN germplasm has…”
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A transgene-free method for rapid and efficient generation of precisely edited pigs without monoclonal selection by Xu, Kui, Zhang, Xiuling, Liu, Zhiguo, Ruan, Jinxue, Xu, Changjiang, Che, Jingjing, Fan, Ziyao, Mu, Yulian, Li, Kui

“…Gene-edited pigs for agricultural and biomedical applications are typically generated using somatic cell nuclear transfer (SCNT). However, SCNT requires the…”
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CRISPR-Cas9-Mediated Cytosine Base Editing Screen for the Functional Assessment of CALR Intron Variants in Japanese Encephalitis Virus Replication by Xiong, Youcai, Xi, Xiaoning, Xiang, Yue, Li, Sheng, Liu, Hailong, Su, Yinyu, He, Ruigao, Xiong, Chong, Xu, Bingrong, Wang, Xinyi, Fu, Liangliang, Zhao, Changzhi, Han, Xiaosong, Li, Xinyun, Xie, Shengsong, Ruan, Jinxue

“…The Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes viral encephalitis in humans, pigs and other mammals across Asia and the…”
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CRISPR/Cas9-Mediated TERT Disruption in Cancer Cells by Wen, Luan, Zhao, Changzhi, Song, Jun, Ma, Linyuan, Ruan, Jinxue, Xia, Xiaofeng, Chen, Y Eugene, Zhang, Jifeng, Ma, Peter X, Xu, Jie

“…Mammalian telomere lengths are primarily regulated by telomerase, a ribonucleoprotein consisting of a reverse transcriptase (TERT) and an RNA subunit (TERC)…”
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CD8+ T Cells Involved in Metabolic Inflammation in Visceral Adipose Tissue and Liver of Transgenic Pigs by Zhang, Kaiyi, Tao, Cong, Xu, Jianping, Ruan, Jinxue, Xia, Jihan, Zhu, Wenjuan, Xin, Leilei, Ye, Huaqiong, Xie, Ning, Xia, Boce, Li, Chenxiao, Wu, Tianwen, Wang, Yanfang, Schroyen, Martine, Xiao, Xinhua, Fan, Jiangao, Yang, Shulin

“…Anti-inflammatory therapies have the potential to become an effective treatment for obesity-related diseases. However, the huge gap of immune system between…”
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Whole-Genome Methylation Analysis Reveals Epigenetic Variation in Cloned and Donor Pigs by Wang, Mengfen, Feng, Shuaifei, Ma, Guanjun, Miao, Yiliang, Zuo, Bo, Ruan, Jinxue, Zhao, Shuhong, Wang, Haiyan, Du, Xiaoyong, Liu, Xiangdong

“…Somatic cloning has had a significant impact on the life sciences and is important in a variety of processes, including medical research and animal production…”
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Delivery of CRISPR/Cas9 Plasmid DNA by Hyperbranched Polymeric Nanoparticles Enables Efficient Gene Editing by Xiu, Kemao, Saunders, Laura, Wen, Luan, Ruan, Jinxue, Dong, Ruonan, Song, Jun, Yang, Dongshan, Zhang, Jifeng, Xu, Jie, Chen, Y Eugene, Ma, Peter X

“…Gene editing nucleases such as CRISPR/Cas9 have enabled efficient and precise gene editing in vitro and hold promise of eventually achieving in vivo gene…”
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Genome editing in livestock: Are we ready for a revolution in animal breeding industry? by Ruan, Jinxue, Xu, Jie, Chen-Tsai, Ruby Yanru, Li, Kui

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Enhancing the antibacterial activities of sow milk via site-specific knock-in of a lactoferrin gene in pigs using CRISPR/Cas9 technology by Han, Xiaosong, Gao, Yang, Li, Guanglei, Xiong, Youcai, Zhao, Changzhi, Ruan, Jinxue, Ma, Yunlong, Li, Xinyun, Li, Changchun, Zhao, Shuhong, Xie, Shengsong

“…Abstract Colostrum quality is a vital factor in mortality and growth performance for piglets. Lactoferrin is an immuno-active milk protein that contributes to…”
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Glucose restriction enhances oxidative fiber formation: A multi-omic signal network involving AMPK and CaMK2 by Zhang, Kaiyi, Xie, Ning, Ye, Huaqiong, Miao, Jiakun, Xia, Boce, Yang, Yu, Peng, Huanqi, Xu, Shuang, Wu, Tianwen, Tao, Cong, Ruan, Jinxue, Wang, Yanfang, Yang, Shulin

“…Skeletal muscle is a highly plastic organ that adapts to different metabolic states or functional demands. This study explored the impact of permanent glucose…”
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A long-term high-fat, high-sucrose diet in Bama minipigs promotes lipid deposition and amyotrophy by up-regulating the myostatin pathway by Ruan, Jinxue, Zhang, Yuanyuan, Yuan, Jing, Xin, Leilei, Xia, Jihan, Liu, Nan, Mu, Yulian, Chen, Yaoxing, Yang, Shulin, Li, Kui

“…Skeletal muscle is as an important regulator of blood glucose and glycolipid metabolism and is closely related to motor ability. The underlying mechanisms by…”
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Genome-Scale CRISPR Knockout Screening Identifies BACH1 as a Key Regulator of Aflatoxin B1-Induced Oxidative Damage by Zhang, Jinfu, Hu, Siyi, Zhao, Changzhi, Zhou, Yuan, Zhang, Lu, Liu, Hailong, Zhou, Peng, Li, Sheng, Fu, Liangliang, Zheng, Zhuqing, Xiang, Yue, Xu, Xuewen, Ruan, Jinxue, Li, Xinyun, Sun, Lvhui, Cao, Gang, Zhao, Shuhong, Wang, Xu, Xie, Shengsong

“…Aflatoxin B1 (AFB1) is amongst the mycotoxins commonly affecting human and animal health, raising global food safety and control concerns. The mechanisms…”
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Pilot study of large-scale production of mutant pigs by ENU mutagenesis by Hai, Tang, Cao, Chunwei, Shang, Haitao, Guo, Weiwei, Mu, Yanshuang, Yang, Shulin, Zhang, Ying, Zheng, Qiantao, Zhang, Tao, Wang, Xianlong, Liu, Yu, Kong, Qingran, Li, Kui, Wang, Dayu, Qi, Meng, Hong, Qianlong, Zhang, Rui, Wang, Xiupeng, Jia, Qitao, Wang, Xiao, Qin, Guosong, Li, Yongshun, Luo, Ailing, Jin, Weiwu, Yao, Jing, Huang, Jiaojiao, Zhang, Hongyong, Li, Menghua, Xie, Xiangmo, Zheng, Xuejuan, Guo, Kenan, Wang, Qinghua, Zhang, Shibin, Li, Liang, Xie, Fei, Zhang, Yu, Weng, Xiaogang, Yin, Zhi, Hu, Kui, Cong, Yimei, Zheng, Peng, Zou, Hailong, Xin, Leilei, Xia, Jihan, Ruan, Jinxue, Li, Hegang, Zhao, Weiming, Yuan, Jing, Liu, Zizhan, Gu, Weiwang, Li, Ming, Wang, Yong, Wang, Hongmei, Yang, Shiming, Liu, Zhonghua, Wei, Hong, Zhao, Jianguo, Zhou, Qi, Meng, Anming

“…N-ethyl-N-nitrosourea (ENU) mutagenesis is a powerful tool to generate mutants on a large scale efficiently, and to discover genes with novel functions at the…”
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Bacterial and Pneumocystis Infections in the Lungs of Gene-Knockout Rabbits with Severe Combined Immunodeficiency by Song, Jun, Wang, Guoshun, Hoenerhoff, Mark J, Ruan, Jinxue, Yang, Dongshan, Zhang, Jifeng, Yang, Jibing, Lester, Patrick A, Sigler, Robert, Bradley, Michael, Eckley, Samantha, Cornelius, Kelsey, Chen, Kong, Kolls, Jay K, Peng, Li, Ma, Liang, Chen, Yuqing Eugene, Sun, Fei, Xu, Jie

“…Using the CRISPR/Cas9 gene-editing technology, we recently produced a number of rabbits with mutations in immune function genes, including FOXN1, PRKDC, RAG1,…”
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