Search Results - "Ruan, Haoqiang"

Click chemistry-based synthesis and anticancer activity evaluation of novel C-14 1,2,3-triazole dehydroabietic acid hybrids by Hou, Wei, Luo, Zhi, Zhang, Guanjun, Cao, Danhui, Li, Di, Ruan, Haoqiang, Ruan, Benfang Helen, Su, Lin, Xu, Hongtao

“…A concise and efficient synthetic approach has been established to readily access a series of novel C-14 1,2,3-triazole-tethered dehydroabietic acid…”
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Identification of a diverse synthetic abietane diterpenoid library and insight into the structure-activity relationships for antibacterial activity by Hou, Wei, Zhang, Guanjun, Luo, Zhi, Li, Di, Ruan, Haoqiang, Ruan, Benfang Helen, Su, Lin, Xu, Hongtao

“…[Display omitted] A diverse natural product-like (NPL) synthetic abietane diterpenoid library containing 86 compounds were obtained and the SARs were studied…”
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Diselenide Covalent Allosteric Inhibitors of Glutaminase with Strong In Vivo Anticancer Activity by Hou, Wei, Chen, Zhao, Pan, Chuqiao, Ni, Maowei, Ruan, Haoqiang, Song, Jun, Lu, Shiying, Bhasin, Aman, Ruan, Benfang Helen

“…Allosteric glutaminase inhibitors demonstrate inhibition of glutamine-dependent cancer cells with low general drug toxicity, but have issues with efficacy in…”
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Ebselen: Mechanisms of Glutamate Dehydrogenase and Glutaminase Enzyme Inhibition by Yu, Yan, Jin, Yanhong, Zhou, Jie, Ruan, Haoqiang, Zhao, Han, Lu, Shiying, Zhang, Yue, Li, Di, Ji, Xiaoyun, Ruan, Benfang Helen

“…Ebselen modulates target proteins through redox reactions with selenocysteine/cysteine residues, or through binding to the zinc finger domains. However, a…”
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Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity by Chen, Zhao, Li, Di, Xu, Ning, Fang, Jinzhang, Yu, Yan, Hou, Wei, Ruan, Haoqiang, Zhu, Panpan, Ma, Renchao, Lu, Shiying, Cao, Danhui, Wu, Rui, Ni, Mowei, Zhang, Wei, Su, Weike, Ruan, Benfang Helen

“…Kidney-type glutaminase [KGA/isoenzyme glutaminase C (GAC)] is becoming an important tumor metabolism target in cancer chemotherapy. Its allosteric inhibitor,…”
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