Search Results - "Rüetschi, Ulla"
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LC–MS/MS Characterization of O‑Glycosylation Sites and Glycan Structures of Human Cerebrospinal Fluid Glycoproteins
Published in Journal of proteome research (01-02-2013)“…The GalNAc O-glycosylation on Ser/Thr residues of extracellular proteins has not been well characterized from a proteomics perspective. We previously reported…”
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Assignment of Saccharide Identities through Analysis of Oxonium Ion Fragmentation Profiles in LC–MS/MS of Glycopeptides
Published in Journal of proteome research (05-12-2014)“…Protein glycosylation plays critical roles in the regulation of diverse biological processes, and determination of glycan structure–function relationships is…”
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An Integrated Workflow for Multiplex CSF Proteomics and PeptidomicsIdentification of Candidate Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease
Published in Journal of proteome research (06-02-2015)“…Many disease processes in the brain are reflected in the protein composition of the cerebrospinal fluid (CSF). In addition to proteins, CSF also contains a…”
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The p38 Signaling Pathway Upregulates Expression of the Epstein-Barr Virus LMP1 Oncogene
Published in Journal of Virology (01-03-2010)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Nuclear Factor-κB Binds to the Epstein-Barr Virus LMP1 Promoter and Upregulates Its Expression
Published in Journal of Virology (01-02-2009)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of CSF biomarkers for frontotemporal dementia using SELDI-TOF
Published in Experimental neurology (01-12-2005)“…This investigation describes the discovery of novel possible cerebrospinal fluid (CSF) biomarkers for frontotemporal dementia (FTD) using surface-enhanced…”
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Enrichment of glycopeptides for glycan structure and attachment site identification
Published in Nature methods (01-11-2009)“…We present a method to enrich for glycoproteins from proteomic samples. Sialylated glycoproteins were selectively periodate-oxidized, captured on hydrazide…”
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Human Urinary Glycoproteomics; Attachment Site Specific Analysis of N- and O-Linked Glycosylations by CID and ECD
Published in Molecular & cellular proteomics (01-04-2012)“…Urine is a complex mixture of proteins and waste products and a challenging biological fluid for biomarker discovery. Previous proteomic studies have…”
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Novel markers of osteogenic and adipogenic differentiation of human bone marrow stromal cells identified using a quantitative proteomics approach
Published in Stem cell research (01-01-2014)“…Today, the tool that is most commonly used to evaluate the osteogenic differentiation of bone marrow stromal cells (BMSCs) in vitro is the demonstration of the…”
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Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid β-peptides in human cerebrospinal fluid
Published in Proceedings of the National Academy of Sciences - PNAS (19-07-2011)“…The proteolytic processing of human amyloid precursor protein (APP) into shorter aggregating amyloid β (Aβ)-peptides, e.g., Aβ1-42, is considered a critical…”
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Epstein–Barr virus nuclear antigen 5 inhibits pre-mRNA cleavage and polyadenylation
Published in Nucleic acids research (15-05-2002)“…The long-standing suspicion that Epstein–Barr virus nuclear antigen 5 (EBNA5) is involved in transcription regulation was recently confirmed by the observation…”
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E2F1, ARID3A/Bright and Oct-2 factors bind to the Epstein–Barr virus C promoter, EBNA1 and oriP, participating in long-distance promoter–enhancer interactions
Published in Journal of general virology (01-05-2012)“…The Epstein–Barr virus (EBV) C promoter (Cp) regulates several genes required for B-cell proliferation in latent EBV infection. The family of repeats (FR)…”
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Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patients
Published in Proteome science (04-10-2013)“…Osteoarthritis (OA) is a destructive joint disease and there are no known biomarkers available for an early diagnosis. To identify potential disease biomarkers…”
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An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid
Published in Journal of mass spectrometry. (01-05-2012)“…Amyloid precursor protein (APP) is the precursor protein to amyloid β (Aβ), the main constituent of senile plaques in Alzheimer's disease (AD). Endogenous Aβ…”
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SorLA Complement-type Repeat Domains Protect the Amyloid Precursor Protein against Processing
Published in The Journal of biological chemistry (06-02-2015)“…SorLA is a neuronal sorting receptor that is genetically associated with Alzheimer disease. SorLA interacts directly with the amyloid precursor protein (APP)…”
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Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease
Published in Journal of Alzheimer's disease (01-01-2013)“…The Chinese hamster ovary cell line 7PA2, stably transfected with the 751 amino acid isoform of amyloid-β protein precursor (AβPP) containing the Val → Phe…”
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An inflammatory equine model demonstrates dynamic changes of immune response and cartilage matrix molecule degradation in vitro
Published in Connective tissue research (2015)“…The molecular aspects of inflammation were investigated in equine articular cartilage explants using quantitative proteomics. Articular cartilage explants were…”
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Proteomic profiling of cerebrospinal fluid in parkinsonian disorders
Published in Parkinsonism & related disorders (01-09-2010)“…Abstract Parkinson’s disease (PD) and atypical parkinsonian disorders (APD), including multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and…”
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Identification of Intracellular Proteins Associated with the EBV-Encoded Nuclear Antigen 5 Using an Efficient TAP Procedure and FT-ICR Mass Spectrometry
Published in Journal of proteome research (01-06-2008)“…Epstein−Barr virus nuclear antigen 5 (EBNA5) is one of the first viral proteins detected after primary EBV infection and has been shown to be required for…”
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Cerebrospinal fluid concentrations of peptides derived from chromogranin B and secretogranin II are decreased in multiple sclerosis
Published in Journal of neurochemistry (01-12-2007)“…Novel biomarkers for multiple sclerosis (MS) could improve diagnosis and provide clues to pathogenesis. In this study surface-enhanced laser…”
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