Influence of arterial compliance on presence and extent of ischaemia during stress echocardiography

Objective: To seek an association between total arterial compliance (TAC) and the extent of ischaemia at stress echocardiography. Design: Cohort study. Setting: Regional cardiac centre. Methods: 255 consecutive patients (147 men; mean (SD) age 58 (8)) presenting for stress echocardiography for clini...

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Bibliographic Details
Published in:	Heart (British Cardiac Society) Vol. 92; no. 1; pp. 40 - 43
Main Authors:	Haluska, B A, Matthys, K, Fathi, R, Rozis, E, Carlier, S G, Marwick, T H
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd and British Cardiovascular Society 01-01-2006 BMJ BMJ Publishing Group LTD BMJ Group
Subjects:	Biological and medical sciences Blood pressure Blood Pressure - physiology CAD Cardiology. Vascular system Cardiovascular disease Cardiovascular Medicine Compliance coronary artery disease Coronary Artery Disease - etiology Coronary Artery Disease - physiopathology Coronary vessels Coronary Vessels - physiopathology Echocardiography, Stress Exercise Female Fitness equipment Heart attacks Heart rate Humans Hypertension ischaemia Male Medical sciences Middle Aged Mortality Myocardial Ischemia - etiology Myocardial Ischemia - physiopathology Pulse Risk factors Supply & demand TAC total arterial compliance wall motion score index WMSI Workloads Sonography Echocardiography Ischemia Cardiovascular disease Circulatory system Cardiology Phlebology Artery Stress
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Summary:	Objective: To seek an association between total arterial compliance (TAC) and the extent of ischaemia at stress echocardiography. Design: Cohort study. Setting: Regional cardiac centre. Methods: 255 consecutive patients (147 men; mean (SD) age 58 (8)) presenting for stress echocardiography for clinical indications were studied. Wall motion score index (WMSI) was calculated and ischaemia was defined by an inducible or worsening wall motion abnormality. Peak WMSI was used to reflect the extent of dysfunction (ischaemia or scar), and ΔWMSI was indicative of extent of ischaemia. TAC was assessed at rest by simultaneous radial applanation tonometry and pulsed wave Doppler in all patients. Results: Ischaemia was identified by stress echocardiography in 65 patients (25%). TAC was similar in the groups with negative and positive echocardiograms (1.08 (0.41) v 1.17 (0.51) ml/mm Hg, not significant). However, the extent of dysfunction was associated with TAC independently of age, blood pressure, risk factors, and use of a β blocker. Moreover, the extent of ischaemia was determined by TAC, risk factors, and use of a β blocker. Conclusion: While traditional cardiovascular risk factors are strong predictors of ischaemia on stress echocardiography, TAC is an independent predictor of the extent of ischaemia.
Bibliography:	ark:/67375/NVC-XTCML6DF-M PMID:16365349 href:heartjnl-92-40.pdf local:0920040 Correspondence to:  Professor Thomas Marwick  University of Queensland Department of Medicine, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4102, Australia; tmarwick@soms.uq.edu.au istex:74F45B3E1288B7ED19A106BBCBC58489CBA5098D ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1355-6037 1468-201X
DOI:	10.1136/hrt.2004.052209