Search Results - "Rozgaja, Tania A."

DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria by Karakasilioti, Ismene, Kamileri, Irene, Chatzinikolaou, Georgia, Kosteas, Theodoros, Vergadi, Eleni, Robinson, Andria Rasile, Tsamardinos, Iannis, Rozgaja, Tania A., Siakouli, Sandra, Tsatsanis, Christos, Niedernhofer, Laura J., Garinis, George A.

“…Lipodystrophies represent a group of heterogeneous disorders characterized by loss of fat tissue. However, the underlying mechanisms remain poorly understood…”
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Origin recognition is the predominant role for DnaA-ATP in initiation of chromosome replication by Grimwade, Julia E, Rozgaja, Tania A, Gupta, Rajat, Dyson, Kyle, Rao, Prassanna, Leonard, Alan C

“…Abstract In all cells, initiation of chromosome replication depends on the activity of AAA+ initiator proteins that form complexes with replication origin DNA…”
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Targeted alpha therapy for chronic lymphocytic leukaemia and non-Hodgkin's lymphoma with the anti-CD37 radioimmunoconjugate 212Pb-NNV003 by Maaland, Astri Fjelde, Saidi, Amal, Torgue, Julien, Heyerdahl, Helen, Stallons, Tania A Rozgaja, Kolstad, Arne, Dahle, Jostein

“…Relapse of chronic lymphocytic leukaemia and non-Hodgkin's lymphoma after standard of care treatment is common and new therapies are needed. The targeted alpha…”
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Two oppositely oriented arrays of low‐affinity recognition sites in oriC guide progressive binding of DnaA during Escherichia coli pre‐RC assembly by Rozgaja, Tania A., Grimwade, Julia E., Iqbal, Maryam, Czerwonka, Christopher, Vora, Mansi, Leonard, Alan C.

“…Summary The onset of chromosomal DNA replication requires highly precise and reproducible interactions between initiator proteins and replication origins to…”
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Building the bacterial orisome: high‐affinity DnaA recognition plays a role in setting the conformation of oriC DNA by Kaur, Gulpreet, Vora, Mansi P., Czerwonka, Christopher A., Rozgaja, Tania A., Grimwade, Julia E., Leonard, Alan C.

“…Summary During assembly of the E. coli pre‐replicative complex (pre‐RC), initiator DnaA oligomers are nucleated from three widely separated high‐affinity DnaA…”
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Low Affinity DnaA-ATP Recognition Sites in E. coli oriC Make Non-equivalent and Growth Rate-Dependent Contributions to the Regulated Timing of Chromosome Replication by Rao, Prassanna, Rozgaja, Tania A, Alqahtani, Abdulaziz, Grimwade, Julia E, Leonard, Alan C

“…Although the mechanisms that precisely time initiation of chromosome replication in bacteria remain unclear, most clock models are based on accumulation of the…”
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Preclinical Investigation of 212Pb-DOTAMTATE for Peptide Receptor Radionuclide Therapy in a Neuroendocrine Tumor Model by Stallons, Tania A. Rozgaja, Saidi, Amal, Tworowska, Izabela, Delpassand, Ebrahim S., Torgue, Julien J.

“…Abstract Somatostatin analogues have been examined as a treatment for somatostatin receptor overexpressing tumors for years; specifically, octreotate (TATE)…”
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Safety and Outcome Measures of First-in-Human Intraperitoneal α Radioimmunotherapy With 212Pb-TCMC-Trastuzumab by Meredith, Ruby F, Torgue, Julien J, Rozgaja, Tania A, Banaga, Eileen P, Bunch, Patty W, Alvarez, Ronald D, Straughn, Jr, J Michael, Dobelbower, Michael C, Lowy, Andrew M

“…One-year monitoring of patients receiving intraperitoneal (IP) Pb-TCMC-trastuzumab to provide long-term safety and outcome data. A secondary objective was to…”
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Targeted alpha therapy for chronic lymphocytic leukaemia and non-Hodgkin's lymphoma with the anti-CD37 radioimmunoconjugate .sup.212Pb-NNV003 by Maaland, Astri Fjelde, Saidi, Amal, Torgue, Julien, Heyerdahl, Helen, Stallons, Tania A. Rozgaja, Kolstad, Arne, Dahle, Jostein

“…Relapse of chronic lymphocytic leukaemia and non-Hodgkin's lymphoma after standard of care treatment is common and new therapies are needed. The targeted alpha…”
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Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging by Robinson, Andria R., Yousefzadeh, Matthew J., Rozgaja, Tania A., Wang, Jin, Li, Xuesen, Tilstra, Jeremy S., Feldman, Chelsea H., Gregg, Siobhán Q., Johnson, Caroline H., Skoda, Erin M., Frantz, Marie-Céline, Bell-Temin, Harris, Pope-Varsalona, Hannah, Gurkar, Aditi U., Nasto, Luigi A., Robinson, Renã A.S., Fuhrmann-Stroissnigg, Heike, Czerwinska, Jolanta, McGowan, Sara J., Cantu-Medellin, Nadiezhda, Harris, Jamie B., Maniar, Salony, Ross, Mark A., Trussoni, Christy E., LaRusso, Nicholas F., Cifuentes-Pagano, Eugenia, Pagano, Patrick J., Tudek, Barbara, Vo, Nam V., Rigatti, Lora H., Opresko, Patricia L., Stolz, Donna B., Watkins, Simon C., Burd, Christin E., Croix, Claudette M. St, Siuzdak, Gary, Yates, Nathan A., Robbins, Paul D., Wang, Yinsheng, Wipf, Peter, Kelley, Eric E., Niedernhofer, Laura J.

“…Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a…”
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Preclinical Investigation of 212 Pb-DOTAMTATE for Peptide Receptor Radionuclide Therapy in a Neuroendocrine Tumor Model by Stallons, Tania A Rozgaja, Saidi, Amal, Tworowska, Izabela, Delpassand, Ebrahim S, Torgue, Julien J

“…Somatostatin analogues have been examined as a treatment for somatostatin receptor overexpressing tumors for years; specifically, octreotate (TATE) and…”
Get full text

Two oppositely oriented arrays of low-affinity recognition sites in oriC guide progressive binding of DnaA during Escherichia coli pre-RC assembly: DnaA-oriC interaction at arrayed sites by Rozgaja, Tania A., Grimwade, Julia E., Iqbal, Maryam, Czerwonka, Christopher, Vora, Mansi, Leonard, Alan C.

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Two oppositely-oriented arrays of low affinity recognition sites in oriC guide progressive binding of DnaA during E. coli pre-RC assembly by Rozgaja, Tania A., Grimwade, Julia E., Iqbal, Maryam, Czerwonka, Christopher, Vora, Mansi, Leonard, Alan C.

“…The onset of chromosomal DNA replication requires highly precise and reproducible interactions between initiator proteins and replication origins to assemble a…”
Get full text

DNA damage triggers a chronic auto-inflammatory response leading to fat depletion in NER progeria by Karakasilioti, Ismene, Kamileri, Irene, Chatzinikolaou, Georgia, Kosteas, Theodoros, Vergadi, Eleni, Robinson, Andria Rasile, Tsamardinos, Iannis, Rozgaja, Tania A, Siakouli, Sandra, Tsatsanis, Christos, Niedernhofer, Laura J., Garinis, George A.

“…Lipodystrophies represent a group of heterogeneous disorders characterized by loss of fat tissue. However, the underlying mechanisms remain poorly understood…”
Get full text