Search Results - "Rozemuller, Annemieke J. M."
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1
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update
Published in Acta neuropathologica (01-01-2010)Get full text
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Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson's Disease
Published in PloS one (18-06-2015)“…Subjects with incidental Lewy body disease (iLBD) may represent the premotor stage of Parkinson's disease (PD). To elucidate molecular mechanisms underlying…”
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Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology
Published in Nature communications (22-08-2022)“…Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are closely related progressive disorders with no available disease-modifying therapy,…”
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Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy
Published in Acta neuropathologica (01-03-2017)“…Microhemorrhages are strongly associated with advanced cerebral amyloid angiopathy (CAA). Although it has been frequently proposed that the deposition of Aβ in…”
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Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration
Published in Journal of neurology (01-05-2010)“…Frontotemporal lobar degeneration (FTLD) is a clinically, genetically and pathologically heterogeneous disorder. Within FTLD with ubiquitin-positive inclusions…”
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Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy
Published in Neuroscience bulletin (02-04-2019)“…Primary age-related tauopathy (PART) is characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology. In the present study,…”
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Neuroinflammation is increased in the parietal cortex of atypical Alzheimer's disease
Published in Journal of neuroinflammation (29-05-2018)“…While most patients with Alzheimer's disease (AD) present with memory complaints, 30% of patients with early disease onset present with non-amnestic symptoms…”
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Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients
Published in Translational psychiatry (20-11-2023)“…Electroconvulsive therapy (ECT) is an effective therapy for depression, but its cellular effects on the human brain remain elusive. In rodents,…”
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Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations
Published in Acta neuropathologica (01-01-2009)Get full text
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Right temporal variant frontotemporal dementia is pathologically heterogeneous: a case-series and a systematic review
Published in Acta neuropathologica communications (03-08-2021)“…Although the right temporal variant frontotemporal dementia (rtvFTD) is characterised by distinct clinical and radiological features, its underlying…”
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Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease
Published in Acta neuropathologica communications (04-06-2018)“…Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) deposits as plaques in the parenchyma and in the walls of cortical and leptomeningeal blood…”
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Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates
Published in Acta neuropathologica communications (24-01-2022)“…Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of intracerebral hemorrhage and cognitive decline that shows close links with…”
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Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response
Published in Acta neuropathologica communications (25-04-2024)“…Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer's disease (AD). This phenomenon…”
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Neuropathology and cognitive performance in self-reported cognitively healthy centenarians
Published in Acta neuropathologica communications (23-07-2018)“…With aging, the incidence of neuropathological hallmarks of neurodegenerative diseases increases in the brains of cognitively healthy individuals. It is…”
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Regional differences in synaptic degeneration are linked to alpha-synuclein burden and axonal damage in Parkinson's disease and dementia with Lewy bodies
Published in Acta neuropathologica communications (03-01-2024)“…Regional differences in synaptic degeneration may underlie differences in clinical presentation and neuropathological disease progression in Parkinson's…”
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Clinical outcomes up to 9 years after [ 18 F]flutemetamol amyloid-PET in a symptomatic memory clinic population
Published in Alzheimer's research & therapy (27-11-2023)“…Previous studies demonstrated increases in diagnostic confidence and change in patient management after amyloid-PET. However, studies investigating…”
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Axonal degeneration in the anterior insular cortex is associated with Alzheimer's co-pathology in Parkinson's disease and dementia with Lewy bodies
Published in Translational neurodegeneration (07-12-2022)“…Axons, crucial for impulse transmission and cellular trafficking, are thought to be primary targets of neurodegeneration in Parkinson's disease (PD) and…”
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Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson's disease dementia
Published in Translational neurodegeneration (20-01-2023)“…Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders. In this study, we aimed…”
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Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors
Published in Acta neuropathologica communications (12-04-2023)“…Movement disorders (MD) have been linked to degeneration of the substantia nigra (SN) in Parkinson's disease and include bradykinesia, rigidity, and tremor…”
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Clusters of co-abundant proteins in the brain cortex associated with fronto-temporal lobar degeneration
Published in Alzheimer's research & therapy (23-03-2023)“…Frontotemporal lobar degeneration (FTLD) is characterized pathologically by neuronal and glial inclusions of hyperphosphorylated tau or by neuronal cytoplasmic…”
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