Search Results - "Rozales, Kinneret"

Cellular proteostasis decline in human senescence by Sabath, Niv, Levy-Adam, Flonia, Younis, Amal, Rozales, Kinneret, Meller, Anatoly, Hadar, Shani, Soueid-Baumgarten, Sharon, Shalgi, Reut

“…Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been established as a hallmark of nematode aging. However, whether…”
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Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens by Rozales, Kinneret, Younis, Amal, Saida, Naseeb, Meller, Anatoly, Goldman, Hodaya, Kellerman, Lior, Heinrich, Ronit, Berlin, Shai, Shalgi, Reut

“…Protein aggregation is a hallmark of neurodegeneration. Here, we find that Huntington’s disease-related HTT-polyQ aggregation induces a cellular proteotoxic…”
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Housing of A350V IQSEC2 pups at 37 °C ambient temperature prevents seizures and permits the development of social vocalizations in adulthood by Jada, Reem, Zag, Liron, Borisov, Veronika, Levy, Nina S., Netser, Shai, Jabarin, Renad, Wagner, Shlomo, Schragenheim-Rozales, Kinneret, Shalgi, Reut, Levy, Andrew P.

“…Mutations in the human IQSEC2 gene are associated with drug-resistant epilepsy and severe behavioral dysfunction. We have focused on understanding one human…”
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An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors by Rogers, Eli J, Jada, Reem, Schragenheim-Rozales, Kinneret, Sah, Megha, Cortes, Marisol, Florence, Matthew, Levy, Nina S, Moss, Rachel, Walikonis, Randall S, Palty, Raz, Shalgi, Reut, Lichtman, Daniela, Kavushansky, Alexandra, Gerges, Nashaat Z, Kahn, Itamar, Umanah, George K E, Levy, Andrew P

“…We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular…”
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Characterization of spontaneous seizures and EEG abnormalities in a mouse model of the human A350V IQSEC2 mutation and identification of a possible target for precision medicine based therapy by Kane, Owen, McCoy, Almedia, Jada, Reem, Borisov, Veronika, Zag, Liron, Zag, Amir, Schragenheim-Rozales, Kinneret, Shalgi, Reut, Levy, Nina S., Levy, Andrew P., Marsh, Eric D.

“…IQSEC2 is an X-linked gene localized to the post synaptic density encoding a GTP exchange factor that regulates NMDA mediated changes in synaptic function…”
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Grb2 regulates the proliferation of hematopoietic stem and progenitors cells by Frelin, Catherine, Ofran, Yishai, Ruston, Julie, Hayun, Michal, Derdikman, Yael, Khier, Yasmine, Rozales, Kinneret, Brenner, Benjamin, Iscove, Norman, Pawson, Tony, Louria-Hayon, Igal

“…Although Hematopoietic Stem and Progenitor Cell (HSPC) proliferation, survival and expansion have been shown to be supported by the cooperative action of…”
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