Search Results - "Royer, Robert E"

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression by Le, Anne, Cooper, Charles R, Gouw, Arvin M, Dinavahi, Ramani, Maitra, Anirban, Deck, Lorraine M, Royer, Robert E, Vander Jagt, David L, Semenza, Gregg L, Dang, Chi V

“…As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through lactate dehydrogenase A (LDHA),…”
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A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerization by Orlando, Robert A, Gonzales, Amanda M, Royer, Robert E, Deck, Lorraine M, Vander Jagt, David L

“…Amyloid-like plaques are characteristic lesions defining the neuropathology of Alzheimer's disease (AD). The size and density of these plaques are closely…”
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Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes by Deck, Lorraine M., Whalen, Lisa J., Hunsaker, Lucy A., Royer, Robert E., Vander Jagt, David L.

“…[Display omitted] Nrf2, which is a member of the cap’n’collar family of transcription factors, is a major regulator of phase II detoxification and anti-oxidant…”
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Comparative Structural Analysis and Kinetic Properties of Lactate Dehydrogenases from the Four Species of Human Malarial Parasites by Brown, W. Michael, Yowell, Charles A, Hoard, Anna, Vander Jagt, Thomas A, Hunsaker, Lucy A, Deck, Lorraine M, Royer, Robert E, Piper, Robert C, Dame, John B, Makler, Michael T, Vander Jagt, David L

“…Parasite lactate dehydrogenase (pLDH) is a potential drug target for new antimalarials owing to parasite dependence on glycolysis for ATP production. The pLDH…”
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Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin by Deck, Lorraine M., Hunsaker, Lucy A., Vander Jagt, Thomas A., Whalen, Lisa J., Royer, Robert E., Vander Jagt, David L.

“…Inflammation and oxidative stress are common in many chronic diseases. Targeting signaling pathways that contribute to these conditions may have therapeutic…”
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Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum by Gomez, Manuel S, Piper, Robert C, Hunsaker, Lucy A, Royer, Robert E, Deck, Lorraine M, Makler, Michael T, Vander Jagt, David L

“…Lactate dehydrogenase from the malarial parasite Plasmodium falciparum has many amino acid residues that are unique compared to any other known lactate…”
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Activation of NFκB is inhibited by curcumin and related enones by Weber, Waylon M., Hunsaker, Lucy A., Roybal, C. Nathaniel, Bobrovnikova-Marjon, Ekaterina V., Abcouwer, Steve F., Royer, Robert E., Deck, Lorraine M., Vander Jagt, David L.

“…The transcription factor NFkappaB (NFκB) is up-regulated in many cancer cells where it contributes to development of the pro-survival, anti-apoptotic state…”
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Isocoumarin-based inhibitors of pancreatic cholesterol esterase by Heynekamp, Justin J., Hunsaker, Lucy A., Vander Jagt, Thomas A., Royer, Robert E., Deck, Lorraine M., Vander Jagt, David L.

“…Pancreatic cholesterol esterase (CEase), which is secreted from the exocrine pancreas, is a serine hydrolase that aids in the bile salt-dependent hydrolysis of…”
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Synthesis and Anti-HIV Activity of 1,1'-Dideoxygossypol and Related Compounds by Royer, Robert E, Deck, Lorraine M, Vander Jagt, Timothy J, Martinez, Francella J, Mills, Ray G, Young, Stephen A, Vander Jagt, David L

“…1,1'-Dideoxygossypol (DDG), 1,1'-dideoxygossylic acid (DDGA), 8-deoxyhemigossypol (DHG), and 8-deoxyhemigossylic acid (DHGA) were synthesized and tested for…”
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Synthesis of hemigossypol and its derivatives by Wei, Jun, Jagt, David L. Vander, Royer, Robert E., Deck, Lorraine M.

“…Hemigossypol ( 3), a sesquiterpene natural product, was previously isolated from Gossypium barbadense and was shown to display improved anti-fungal activity…”
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Synthesis of benzyl substituted naphthalenes from benzylidene tetralones by Deck, Lorraine M., Mgani, Quintino, Martinez, Andrea, Martinic, Alice, Whalen, Lisa J., Vander Jagt, David L., Royer, Robert E.

“…A convenient and efficient synthesis of novel highly substituted dimethoxybenzylnaphthalenes, which are precursors to several dihydroxynaphthoic acids, is…”
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Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4 by YUE YU, DECK, Jason A, HUNSAKER, Lucy A, DECK, Lorraine M, ROYER, Robert E, GOLDBERG, Erwin, VANDER JAGT, David L

“…Human lactate dehydrogenases (LDH-A4, -B4, and -C4) are highly homologous with 84-89% sequence similarities and 69-75% amino acid identities. Active site…”
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Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications by Vander Jagt, David L., Hassebrook, Robyn K., Hunsaker, Lucy A., Brown, William M., Royer, Robert E.

“…Numerous physiological aldehydes besides glucose are substrates of aldose reductase, the first enzyme of the polyol pathway which has been implicated in the…”
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Selective Inhibitors of Human Lactate Dehydrogenases and Lactate Dehydrogenase from the Malarial Parasite Plasmodium falciparum by DECK, Lorraine M., ROYER, Robert E., CHAMBLEE, Brian B., HERNANDEZ, Valerie M., MALONE, Richard R., TORRES, Jose E., HUNSAKER, Lucy A., PIPER, Robert C., MAKLER, Michael T., VANDER JAGT, David L.

“…Derivatives of the sesquiterpene 8-deoxyhemigossylic acid (2, 3-dihydroxy-6-methyl-4-(1-methylethyl)-1-naphthoic acid) were synthesized that contained altered…”
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Substrate specificity of human aldose reductase: identification of 4-hydroxynonenal as an endogenous substrate by bander Jagt, David L., Kolb, Natasha S., bander Jagt, Timothy J., Chino, Joachim, Martinez, Francella J., Hunsaker, Lucy A., Royer, Robert E.

“…Aldose reductase, which catalyzes the reduction of glucose to sorbitol as part of the polyol pathway, has been implicated in the development of diabetic…”
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The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum by Dando, Caroline, Schroeder, Eric R, Hunsaker, Lucy A, Deck, Lorraine M, Royer, Robert E, Zhou, Xiulan, Parmley, Stephen F, Vander Jagt, David L

“…Toxoplasma gondii differentially expresses two forms of lactate dehydrogenase in tachyzoites and bradyzoites, respectively, designated LDH1 and LDH2…”
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Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes by Vander Jagt, David L., Hunsaker, Lucy A., Vander Jagt, Timothy J., Gomez, Manuel S., Gonzales, Donna M., Deck, Lorraine M., Royer, Robert E.

“…4-Hydroxynonenal, a product of oxidative degradation of unsaturated lipids, is an endogenous reactive α,β-unsaturated aldehyde with numerous biological…”
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17-β-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold by Brown, William M, Metzger, Louis E, Barlow, Jeremy P, Hunsaker, Lucy A, Deck, Lorraine M, Royer, Robert E, Vander Jagt, David L

“…17-β-Hydroxysteroid dehydrogenase type 1 (17βHSD1), also called estradiol dehydrogenase, catalyzes the NADPH-dependent reduction of the weak estrogen, estrone,…”
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Gossypol and derivatives: a new class of aldose reductase inhibitors by Deck, Lorraine M, Vander Jagt, David L, Royer, Robert E

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Selective Inhibitors of Human Lactate Dehydrogenases and Lactate Dehydrogenase from the Malarial Parasite Plasmodium f alciparum by Deck, Lorraine M, Royer, Robert E, Chamblee, Brian B, Hernandez, Valerie M, Malone, Richard R, Torres, Jose E, Hunsaker, Lucy A, Piper, Robert C, Makler, Michael T, Vander Jagt, David L

“…Derivatives of the sesquiterpene 8-deoxyhemigossylic acid (2,3-dihydroxy-6-methyl-4-(1-methylethyl)-1-naphthoic acid) were synthesized that contained altered…”
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