Search Results - "Roybal, Jonathon D."

Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma by Pankova, Daniela, Chen, Yulong, Terajima, Masahiko, Schliekelman, Mark J, Baird, Brandi N, Fahrenholtz, Monica, Sun, Li, Gill, Bartley J, Vadakkan, Tegy J, Kim, Min P, Ahn, Young-Ho, Roybal, Jonathon D, Liu, Xin, Parra Cuentas, Edwin Roger, Rodriguez, Jaime, Wistuba, Ignacio I, Creighton, Chad J, Gibbons, Don L, Hicks, John M, Dickinson, Mary E, West, Jennifer L, Grande-Allen, K Jane, Hanash, Samir M, Yamauchi, Mitsuo, Kurie, Jonathan M

“…Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how collagen cross-linking is regulated in…”
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The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL by Ungewiss, Christin, Rizvi, Zain H., Roybal, Jonathon D., Peng, David H., Gold, Kathryn A., Shin, Dong-Hoon, Creighton, Chad J., Gibbons, Don L.

“…Tumor cell metastasis is a complex process that has been mechanistically linked to the epithelial-mesenchymal transition (EMT). The double-negative feedback…”
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miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1 by Roybal, Jonathon D, Zang, Yi, Ahn, Young-Ho, Yang, Yanan, Gibbons, Don L, Baird, Brandi N, Alvarez, Cristina, Thilaganathan, Nishan, Liu, Diane D, Saintigny, Pierre, Heymach, John V, Creighton, Chad J, Kurie, Jonathan M

“…The microRNA-200 (miR-200) family is part of a gene expression signature that predicts poor prognosis in lung cancer patients. In a mouse model of…”
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Thy-1+ Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis by Schliekelman, Mark J., Creighton, Chad J., Baird, Brandi N., Chen, Yulong, Banerjee, Priyam, Bota-Rabassedas, Neus, Ahn, Young-Ho, Roybal, Jonathon D., Chen, Fengju, Zhang, Yiqun, Mishra, Dhruva K., Kim, Min P., Liu, Xin, Mino, Barbara, Villalobos, Pamela, Rodriguez-Canales, Jaime, Behrens, Carmen, Wistuba, Ignacio I., Hanash, Samir M., Kurie, Jonathan M.

“…Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that…”
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Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression by Chen, Limo, Gibbons, Don L., Goswami, Sangeeta, Cortez, Maria Angelica, Ahn, Young-Ho, Byers, Lauren A., Zhang, Xuejun, Yi, Xiaohui, Dwyer, David, Lin, Wei, Diao, Lixia, Wang, Jing, Roybal, Jonathon D., Patel, Mayuri, Ungewiss, Christin, Peng, David, Antonia, Scott, Mediavilla-Varela, Melanie, Robertson, Gordon, Jones, Steve, Suraokar, Milind, Welsh, James W., Erez, Baruch, Wistuba, Ignacio I., Chen, Lieping, Peng, Di, Wang, Shanshan, Ullrich, Stephen E., Heymach, John V., Kurie, Jonathan M., Qin, F. Xiao-Feng

“…Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We…”
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A Synthetic Matrix with Independently Tunable Biochemistry and Mechanical Properties to Study Epithelial Morphogenesis and EMT in a Lung Adenocarcinoma Model by GILL, Bartley J, GIBBONS, Don L, ROUDSARI, Laila C, SAIK, Jennifer E, RIZVI, Zain H, ROYBAL, Jonathon D, KURIE, Jonathan M, WEST, Jennifer L

“…Better understanding of the biophysical and biochemical cues of the tumor extracellular matrix environment that influence metastasis may have important…”
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Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression by Chen, Limo, Yi, Xiaohui, Goswami, Sangeeta, Ahn, Young-Ho, Roybal, Jonathon D., Yang, Yongbin, Diao, Lixia, Peng, Di, Peng, David, Fradette, Jared J., Wang, Jing, Byers, Lauren A., Kurie, Jonathan M., Ullrich, Stephen E., Qin, F. Xiao-Feng, Gibbons, Don L.

“…Cancer cells modulate the recruitment and function of inflammatory cells to create an immunosuppressive microenvironment that favors tumor growth and…”
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Fibulin-2 is a driver of malignant progression in lung adenocarcinoma by Baird, Brandi N, Schliekelman, Mark J, Ahn, Young-Ho, Chen, Yulong, Roybal, Jonathon D, Gill, Bartley J, Mishra, Dhruva K, Erez, Baruch, O'Reilly, Michael, Yang, Yanan, Patel, Mayuri, Liu, Xin, Thilaganathan, Nishan, Larina, Irina V, Dickinson, Mary E, West, Jennifer L, Gibbons, Don L, Liu, Diane D, Kim, Min P, Hicks, John M, Wistuba, Ignacio I, Hanash, Samir M, Kurie, Jonathan M

“…The extracellular matrix of epithelial tumors undergoes structural remodeling during periods of uncontrolled growth, creating regional heterogeneity and…”
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The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers by Kundu, S T, Byers, L A, Peng, D H, Roybal, J D, Diao, L, Wang, J, Tong, P, Creighton, C J, Gibbons, D L

“…Metastatic lung cancer is one of the most lethal forms of cancer and molecular pathways driving metastasis are still not clearly elucidated. Metastatic cancer…”
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Abstract B44: The microRNA-200/Zeb1 axis regulates ECM-dependent Src signaling, cytoskeletal changes and cancer cell invasion by Ungewiss, Christin, Roybal, Jonathon D., Peng, David H., Gibbons, Don L.

“…Abstract The microRNA-200 family (miR-200) has been shown to be a master regulator of epithelial-to-mesenchymal transition (EMT), partially through a…”
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Abstract B36: The role of the microRNA-200 family in the regulation of tumor cell signaling and metastasis in lung cancer by Roybal, Jonathon D., Peng, David H., Ungewiss, Christin, Mandal, Pijus K., McMurray, John S., Byers, Lauren A., Gibbons, Don L.

“…Abstract Lung cancer is the deadliest cancer in the United States due primarily to the development of metastatic disease, resulting in a 16% five year overall…”
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Abstract C56: microRNA-200 control of tumor cell cytoskeletal changes and invasion by Ungewiss, Christin, Roybal, Jonathon D., Peng, David H., Gibbons, Don L.

“…Abstract Lung cancer is the leading cause of all cancer-related deaths, accounting for 160,000 deaths per year in the US, primarily caused by metastasis…”
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Abstract C57: The role of the microRNA-200 family in the regulation of tumor cell signaling and metastasis in lung cancer by Roybal, Jonathon D., Peng, David H., Ungewiss, Christin, Mandal, Pijus K., McMurray, John S., Byers, Lauren A., Gibbons, Don L.

“…Abstract Lung cancer is one of the deadliest cancers in the United States due primarily to the development of metastatic disease, resulting in a 16% five year…”
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The microRNA-200/Zeb1 axis regulates ECM-dependent [beta]1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL by Ungewiss, Christin, Rizvi, Zain H, Roybal, Jonathon D, Peng, David H, Gold, Kathryn A, Shin, Dong-hoon, Creighton, Chad J, Gibbons, Don L

“…Tumor cell metastasis is a complex process that has been mechanistically linked to the epithelial-mesenchymal transition (EMT). The double-negative feedback…”
Get full text