Search Results - "Royal, Mike"

Plasma and Cerebrospinal Fluid Pharmacokinetic Parameters After Single-Dose Administration of Intravenous, Oral, or Rectal Acetaminophen by Singla, Neil K., Parulan, Cherri, Samson, Roselle, Hutchinson, Joel, Bushnell, Rick, Beja, Evelyn G., Ang, Robert, Royal, Mike A.

“…Background:  This is the first study to compare plasma and cerebrospinal fluid (CSF) pharmacokinetics of intravenous (IV), oral (PO), or rectal (PR)…”
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A Literature Review of Randomized Clinical Trials of Intravenous Acetaminophen (Paracetamol) for Acute Postoperative Pain by Macario, Alex, Royal, Mike A.

“…Introduction:  This study's objective was to systematically review the literature to assess analgesic outcomes of intravenous (IV) acetaminophen for acute…”
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A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Repeat-Dose Study of Two Intravenous Acetaminophen Dosing Regimens for the Treatment of Pain After Abdominal Laparoscopic Surgery by Wininger, Steven J., MD, Miller, Howard, MD, Minkowitz, Harold S., MD, Royal, Mike A., MD, JD, MBA, Ang, Robert Y., MD, Breitmeyer, James B., MD, PhD, Singla, Neil K., MD

“…Abstract Background Intravenous acetaminophen has been approved in Europe and elsewhere for the treatment of acute pain and fever, and was recently approved by…”
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Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendations by Turk, Dennis C., Dworkin, Robert H., Burke, Laurie B., Gershon, Richard, Rothman, Margaret, Scott, Jane, Allen, Robert R., Atkinson, J. Hampton, Chandler, Julie, Cleeland, Charles, Cowan, Penny, Dimitrova, Rozalina, Dionne, Raymond, Farrar, John T., Haythornthwaite, Jennifer A., Hertz, Sharon, Jadad, Alejandro R., Jensen, Mark P., Kellstein, David, Kerns, Robert D., Manning, Donald C., Martin, Susan, Max, Mitchell B., McDermott, Michael P., McGrath, Patrick, Moulin, Dwight E., Nurmikko, Turo, Quessy, Steve, Raja, Srinivasa, Rappaport, Bob A., Rauschkolb, Christine, Robinson, James P., Royal, Mike A., Simon, Lee, Stauffer, Joseph W., Stucki, Gerold, Tollett, Jane, von Stein, Thorsten, Wallace, Mark S., Wernicke, Joachim, White, Richard E., Williams, Amanda C., Witter, James, Wyrwich, Kathleen W.

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Intravenous Acetaminophen for Pain after Major Orthopedic Surgery: An Expanded Analysis by Sinatra, Raymond S., Jahr, Jonathan S., Reynolds, Lowell, Groudine, Scott B., Royal, Mike A., Breitmeyer, James B., Viscusi, Eugene R.

“…Background and Methods:  From the time that Sinatra et al. (Anesthesiology. 2005;102:822) was published to FDA apaproval of intravenous (IV) acetaminophen, an…”
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Childhood asthma and use during pregnancy of acetaminophen. A critical review by Scialli, Anthony R., Ang, Robert, Breitmeyer, James, Royal, Mike A.

“…▶ There are conflicting results on acetaminophen use during pregnancy and childhood asthma. ▶ Acetaminophen use may be a marker for infectious or inflammatory…”
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Novel delivery systems for postoperative analgesia by Palmer, Pamela P., M.D., Ph.D, Royal, Mike A., M.D., JD, MBA, Miller, Ronald D., M.D., M.S

“…Moderate-to-severe postoperative pain is usually controlled using a multimodal approach, including opioids. Intravenously administered patient-controlled…”
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A Randomized Study of the Efficacy and Safety of Intravenous Acetaminophen Compared to Oral Acetaminophen for the Treatment of Fever by Frank Peacock, W., Breitmeyer, James B., Pan, Christine, Smith, William B., Royal, Mike A.

“…ACADEMIC EMERGENCY MEDICINE 2011; 18:360–366 © 2011 by the Society for Academic Emergency Medicine Objectives:  The purpose of this study was to assess the…”
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A review of the literature on the effects of acetaminophen on pregnancy outcome by Scialli, Anthony R., Ang, Robert, Breitmeyer, James, Royal, Mike A.

“…Acetaminophen is commonly used during pregnancy. Experimental animal studies do not suggest increased malformations after therapeutic use of single-ingredient…”
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IV acetaminophen: Efficacy of a single dose for postoperative pain after hip arthroplasty: subset data analysis of 2 unpublished randomized clinical trials by Singla, Neil K, Hale, Martin E, Davis, Jeffrey C, Bekker, Alex, Gimbel, Joseph, Jahr, Jonathan, Royal, Mike A, Ang, Robert Y, Viscusi, Eugene R

“…Inadequate control of postoperative pain after orthopedic procedures may trigger complications that increase morbidity. Multimodal analgesia is used to manage…”
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Safety of Multiple-Dose Intravenous Acetaminophen in Adult Inpatients by Candiotti, Keith A., Bergese, Sergio D., Viscusi, Eugene R., Singla, Sonia K., Royal, Mike A., Singla, Neil Kumar

“…Background.  Intravenous (IV) acetaminophen provides rapid and effective analgesia in the postoperative and inpatient settings. The utility and efficacy of…”
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Botulinum toxins in pain management by Royal, Mike A

“…BTs are a useful treatment in refractory MPS and have shown promise in various superficial neuropathic pain syndromes. Presumably BTs work by breaking the…”
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Safety and efficacy of intravenous acetaminophen in the elderly after major orthopedic surgery: subset data analysis from 3, randomized, placebo-controlled trials by Jahr, Jonathan S, Breitmeyer, James B, Pan, Christine, Royal, Mike A, Ang, Robert Y

“…As the number of patients aged 65 years and older increases, joint replacement has become a frequent procedure after progressive osteoarthritis or fractures…”
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Confusion: Acetaminophen Dosing Changes Based on NO Evidence in Adults by Krenzelok, Edward P., Royal, Mike A.

“…Acetaminophen (paracetamol) plays a vital role in American health care, with in excess of 25 billion doses being used annually as a nonprescription medication…”
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Botulinum Toxin in Pain Management of Soft Tissue Syndromes by Smith, Howard S, Audette, Joseph, Royal, Mike A

“…Botulinum toxin is approved for the treatment of muscle overactivity associated with several disorders, such as dystonias. However, control of muscle spasm…”
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A Phase 1, Open-Label, Dose-Escalation Study of the Safety and Efficacy of Anti-CD38 Antibody Drug Conjugate (STI-6129) in Patients with Relapsed or Refractory Multiple Myeloma by Chakraborty, Rajshekhar, Yan, Ying, Royal, Mike

“…Background: With the advent of several new agents in the treatment of multiple myeloma, including proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs),…”
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SOR-CART-MM-001 Study: A Phase I, Open-Label, Dose-Escalation, Pharmacokinetic, and Pharmacodynamic Study of Safety and Efficacy of CAR2 Anti-CD38 A2 CAR-T Cells in Patients with Relapsed or Refractory Multiple Myeloma (RRMM) by Stadtmauer, Edward A., Elghawy, Omar, Roberts, Todd F., Madduri, Deepu, Ailawadhi, Sikander, Royal, Mike, Yan, Ying

“…Background: B-cell maturation antigen (BCMA) directed chimeric antigen receptor (CAR-) T cells, show high response rates in patients with highly refractory and…”
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Safety and population pharmacokinetic analysis of intravenous acetaminophen in neonates, infants, children, and adolescents with pain or Fever by Zuppa, Athena F, Hammer, Gregory B, Barrett, Jeffrey S, Kenney, Brian F, Kassir, Nastya, Mouksassi, Samer, Royal, Mike A

“…The administration of acetaminophen via the oral and rectal routes may be contraindicated in specific clinical settings. Intravenous administration provides an…”
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15730 A randomized, double-blind, placebo-controlled, single ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of CBP-201 administered to healthy adult subjects by Royal, Mike A., White, Jeffery, Snyder, Ben, Wei, Zheng, Pan, Wubin, Wang, Junying, Sansone, Kenneth J., Yang, Xin

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The Maverick trial: A phase 2 study of abivertinib in patients (pts) with metastatic castration resistant prostate cancer (mCRPC) by McKay, Rana R., Armstrong, Andrew J., Emamekhoo, Hamid, Gourdin, Theodore Stewart, Heath, Elisabeth I., Hussain, Arif, Ornstein, Moshe Chaim, Sharifi, Nima, Viscuse, Paul Vincent, Yan, Ying, Royal, Mike A.

“…TPS5106 Background: Abivertinib is a potent, small molecule third-generation tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR), Bruton…”
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